New approaches for the design of HIV-1 protease inhibitors

Project: PHD

Project Details

Description

In general, enzyme inhibitors used as therapeutic agents are organic molecules that interact mainly with the proteins through hydrogen bonding and van der Waals contacts. Metal-organic complexes hold the attractive promise of forming stronger attachments with the target by combining the coordination ability of metals with the stereoelectronic properties of the ligand.
StatusFinished
Effective start/end date1/10/9831/12/01

Keywords

  • docking
  • HIV-1 PR
  • molecular mechanics
  • SAR
  • inhibitors
  • molecular dynamics