In general, enzyme inhibitors used as therapeutic agents are organic molecules that interact mainly with the proteins through hydrogen bonding and van der Waals contacts. Metal-organic complexes hold the attractive promise of forming stronger attachments with the target by combining the coordination ability of metals with the stereoelectronic properties of the ligand.
|Effective start/end date||1/10/98 → 31/12/01|
- HIV-1 PR
- molecular mechanics
- molecular dynamics