Modelling of the D3 dopaminergic receptor and development of a selective D3 antagonists pharmacophoric model

Project: PHD

Project Details

Description

The dopaminergic receptors are involved in neurotransmission. Some neuroleptics are used as therapy against certain malfunctionings of the nervous system but give way to extrapyramidal side effects.
StatusFinished
Effective start/end date1/10/9431/08/00

Keywords

  • dopamine
  • schizophrenia
  • G protein-coupled receptors
  • neuroleptics
  • structure prediction
  • XRD
  • stereoelectronic properties