Microarray for the identification of tumor antigens MAGE

Project: Research

Description

MAGE antigens are members of closely related proteins, which are typical of tumor cells. The MAGE family comprises at least 12 members. These antigens are of particular interest for antitumor immunotherapy because they are strictly tumor-specific and shared by many different tumors.

The MAGEchip give simultaneous identification of MAGE genes expressed in tumors. Identification is performed by RT-PCR using consensus primers followed by sequence discrimination on a DNA microarray bearing capture probes specific for the 12 MAGE genes.
AcronymMAGEchips
StatusFinished
Effective start/end date1/01/9831/12/00

Keywords

  • immunotherapy
  • DNA microarray
  • gene MAGE