Insights into 5-LOX inhibitors binding modes, in order to help in the design of dual 5-LOX/COX-2 inhibitors

Project: PHD

Project Details


The arachidonic acid cascade is notably involved in various pathological processes such as inflammation and allergic disorders. It is comprised of two major metabolic pathways: the COX (with COX-1 and COX-2) and the 5-LOX ones. Simultaneous inhibition of 5-LOX and COX-2 appears to be a promising alternative to classical NSAIDs and even COX-2 inhibitors. Whereas COXs have already been extensively studied, current knowledge about 5-LOX is much more limited.
Therefore, this project aims the structural characterization of human 5-LOX and the study of its interaction with different selective inhibitors. Insights into pharmacophoric features, essential for an optimal inhibitory potency, will help in the design of new dual 5-LOX/COX-2 inhibitors.
Effective start/end date1/09/0128/02/06


  • anti-inflammatory
  • molecular modelisation
  • pharmacophore
  • 5-LOX
  • COX-2
  • drug design
  • homology modelling


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