Innovative formulation of high potential APIs : Solid-state efficient combination through cocrystallization

  • TILBORG, Anaelle (PI)

Project: Research

Project Details

Description

Cocrystallization aims to form new crystalline materials consisting of two (or
more) chemical entities in the same network and has been particularly
developed these last years in the pharmaceutical field. In contrast with salts,
cocrystals can be formed with non-ionizable compounds and they allow for
the optimization of dissolution properties of active compounds while
maintaining therapeutic effect. On the other hand, combination drugs tend
to be developed because of their advantages on classical administration:
greater therapeutic effect and potential synergy. But problems can appear
during the formulation phase. In this context, the research project aims to
develop innovative cocrystals combining APIs. The main difficulty is the
formation of the new cocrystal, which can be more challenging because the
two selected molecules could be more difficult to cocrystallize.
AcronymAPI-ComB
StatusFinished
Effective start/end date1/10/1330/06/15

Research Output

Crystal structure of 2, 2′-oxybis(4-methylquinoline)

Tilborg, A., 2015, In : Acta crystallographica. Section E: Structure reports online. 71, 2, p. 180-183 4 p.

Research output: Contribution to journalArticle

  • Solid-state investigation on a new dimorphic substituted N-salicylidene compound: Insights into its thermochromic behaviour

    Carletta, A., Dubois, J., Tilborg, A. & Wouters, J., 14 May 2015, In : CrystEngComm. 17, 18, p. 3509-3518 10 p.

    Research output: Contribution to journalArticle

  • 20 Downloads (Pure)

    Activities

    • 2 Participation to a Symposium, a study Day
    • 2 Participation in conference

    8 th Annual meeting of the SFMBBM doctoral school

    Anaëlle Tilborg (Poster)

    14 Nov 2014

    Activity: Participating in or organising an event typesParticipation in conference

    8th Belgian Crystallography Symposium

    Anaëlle Tilborg (Poster)

    15 Oct 2014

    Activity: Participating in or organising an event typesParticipation in conference

    40ième Journées d’Etude des Equilibres entre Phases (JEEP)

    Anaëlle Tilborg (Poster)

    26 Mar 201428 Mar 2014

    Activity: Participating in or organising an event typesParticipation to a Symposium, a study Day

    Equipment