In order to investigate the regulation's network of CAK complex in fission yeast, we identify a Skp1 homologue. The genetic analysis of the skp1-deleted cells and the skp1-3f mutant suuported that Skp1 and Pof6 play an essential role in cytokinesis in an non-SCF complex and that Skp1 is required prior the centrosome segregation in mitosis in a SCF dependent manner. The molecular mechanisms involved in these two proccess of the cell cycle are under investigation
|Effective start/end date||1/10/98 → 30/09/02|
- Cell cycle
- SCF complex
- S. pombe
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