Enzymologic, mechanistic and pharmacological study of specific inhibitors of serine proteases implicated in hemostasis disorders

Project: PHD

Project Details

Description

This project aims to evaluate specific inhibitors of coagulation factors (serine proteases) implicated in hemostasis disorders using three main appproaches:
- Enzymology: efficacity and selectivity on serine proteases
- Inhibition mechanisms: kinetics and characterisation of enzyme-inhibitor complexes (LC-MS)
- Pharmacology: anticoagulant activity (CAT), antiplatelet activity (aggregometry), antithrombotic activity (rat thrombosis models)
AcronymTHROMBO
StatusActive
Effective start/end date1/09/04 → …

Keywords

  • thrombosis

Research Output

  • 1 Conference contribution
  • 1 Poster
  • 1 Article
  • coauthor on lecture: NOVEL DEVELOPMENT IN COUMARINS AS FXIIa INHIBITORS: IMPROVEMENT OF SOLUBILITY

    Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013, Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. Vol. OC05.

    Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

    Open Access
    File
  • Open Access
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