Enzymologic, mechanistic and pharmacological study of specific inhibitors of serine proteases implicated in hemostasis disorders

Project: PHD

Project Details

Description

This project aims to evaluate specific inhibitors of coagulation factors (serine proteases) implicated in hemostasis disorders using three main appproaches:
- Enzymology: efficacity and selectivity on serine proteases
- Inhibition mechanisms: kinetics and characterisation of enzyme-inhibitor complexes (LC-MS)
- Pharmacology: anticoagulant activity (CAT), antiplatelet activity (aggregometry), antithrombotic activity (rat thrombosis models)
AcronymTHROMBO
StatusActive
Effective start/end date1/09/04 → …

Keywords

  • thrombosis

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
View full fingerprint
  • 1 Conference contribution
  • 1 Poster
  • 1 Article