Project Details
Description
The Boron Neutron Capture Therapy (BNCT) is a binary form of cancer therapy. The goal of this project is to apply the BNCT to the carbonic anhydrases IX and XII (CAs) overexpressed and involved in the cancer. The challenge of this work consists in synthesizing boron-containing carbonic anhydrase inhibitors to selectively inhibit CA-IX and CA-XII, then, by neutron irradiation, to kill the surrounding cancer cells by alpha particules produced by the boron desintegration.
Acronym | BNCT |
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Status | Active |
Effective start/end date | 1/10/06 → … |
Keywords
- cancer
- molecular design
- medicinal chemistry
- boron therapy