Design, synthesis and biological evaluation of inhibitors of cyclooxygenases

Project: PHD

Project Details


Non-steroidal anti-inflammatory drugs (NSAIDs) widely used in the treatment of inflammation but are a significant cause of adverse events such as gastrointestinal ulceration. Developement of selective COX-2 inhibitors should provide the same efficacy as NSAIDS with minimal ulcerogenic activity. In this project, synthesis and developement of a new serie of selective COX-2 inhibitors have been undertaken.
Effective start/end date8/12/991/01/05


  • organic synthesis
  • inhibitors
  • COX-1
  • COX-2

Student Theses

Conception, synthèse et évaluation biologique de 2-thiohydantoïnes en tant qu'inhibiteurs potentiels des cyclooxygénases

Author: Gauthier, M., 17 Dec 2004

Supervisor: Masereel, B. (Supervisor), Flamion, B. (Jury), Pochet, L. (Jury), Vincent, S. (Jury), Wouters, J. (Jury), GUEIFFIER, A. (External person) (Jury) & Lambert, D. M. (External person) (Jury)

Student thesis: Doc typesDoctor of Sciences