Design, synthesis and biological evaluation of inhibitors of cyclooxygenases

Project: PHD

Project Details


Non-steroidal anti-inflammatory drugs (NSAIDs) widely used in the treatment of inflammation but are a significant cause of adverse events such as gastrointestinal ulceration. Developement of selective COX-2 inhibitors should provide the same efficacy as NSAIDS with minimal ulcerogenic activity. In this project, synthesis and developement of a new serie of selective COX-2 inhibitors have been undertaken.
Effective start/end date8/12/991/01/05


  • organic synthesis
  • inhibitors
  • COX-1
  • COX-2


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