Conception of dual inhibitors Histones deacetylase/DNA (cytosine-5) methyltransferase

Project: PHD

Description

The aim of this project is the conception of new inhibitors which inhibit Histones Deacetylases and DNA (cytosine-5) methyltransferases at once, two enzymes involved in epigenetic modifications of DNA. These modifications can be involved in tumorigenesis.
StatusFinished
Effective start/end date1/10/0630/09/10

Keywords

  • HDAC
  • DNA methyltransferase
  • protein
  • molecular modelling