Biological evaluation of inhibitors of Na+/H+ and Na+/Ca+ exchanger

One of the predominant mechanism by which cells adapt to intracellular acidosis is through the Na+/H+ antiport system (NHE). An excessive stimulation of NHE could be involved in ischemic and reperfusion injuries, like arrhythmias, myocardial contracture, stunning and tissue necrosis. Consequently, to attenuate the harmful consequences of an excessive NHE activation, we have developed a new serie of inhibitors based on amiloride.