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Research Output 1993 2019

2019

Localized incorporation of outer membrane components in the pathogen Brucella abortus

Vassen, V., Valotteau, C., Feuillie, C., Formosa-Dague, C., Dufrêne, Y. F. & De Bolle, X., 1 Mar 2019, In : The EMBO journal. 38, 5, e100323.

Research output: Contribution to journalArticle

Brucella abortus
Pathogens
Membranes
Lipopolysaccharides
Porins
2 Downloads (Pure)

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

Poncin, K., Roba, A., Jimmidi, R., Potemberg, G., Fioravanti, A., Francis, N., Willemart, K., Zeippen, N., Machelart, A., Biondi, E. G., Muraille, E., Vincent, S. P. & De Bolle, X., 24 Oct 2019, In : Nature Communications. 10, 1, p. 4847 4847.

Research output: Contribution to journalArticle

Open Access
File
Brucella abortus
pathogens
Pathogens
Repair
occurrences
3 Downloads (Pure)

Route of Infection Strongly Impacts the Host-Pathogen Relationship

Demars, A., Lison, A., Machelart, A., Van Vyve, M., Potemberg, G., Vanderwinden, J-M., De Bolle, X., Letesson, J-J. & Muraille, E., 1 Jan 2019, In : Frontiers in Immunology. 10, JULY, p. 1589 23 p., 1589.

Research output: Contribution to journalArticle

Open Access
File
Brucella
Infection
T-Lymphocytes
Brucella melitensis
Lung
2018

Brucella central carbon metabolism: an update

Barbier, T., Zúñiga-Ripa, A., Moussa, S., Plovier, H., Sternon, J. F., Lázaro-Antón, L., Conde-Álvarez, R., De Bolle, X., Iriarte, M., Moriyón, I. & Letesson, J. J., 4 Mar 2018, In : Critical Reviews in Microbiology. 44, 2, p. 182-211 30 p.

Research output: Contribution to journalReview article

Brucella
Carbon
Erythritol
Pentoses
water dikinase pyruvate
Alphaproteobacteria
Brucella abortus
Proteobacteria
Learning
Caulobacter crescentus
15 Downloads (Pure)

Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria

Lobet, E., Willemart, K., Ninane, N., Demazy, C., Sedzicki, J., Lelubre, C., De Bolle, X., Renard, P., Raes, M., Dehio, C., Letesson, J. J. & Arnould, T., 26 Mar 2018, In : Scientific Reports. 8, 1, p. 1-17 17 p., 5173.

Research output: Contribution to journalArticle

Open Access
File
Brucella abortus
Brucella
Mitochondria
Apoptosis
Bacteria

PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis

David, B., Duchêne, M-C., Haustenne, G. L., Pérez-Núñez, D., Chapot-Chartier, M-P., De Bolle, X., Guédon, E., Hols, P. & Hallet, B., 1 May 2018, In : PLoS ONE. 13, 5, p. e0198014 e0198014.

Research output: Contribution to journalArticle

Lactococcus lactis
Elongation
cell growth
Cells
Machinery

Transposon sequencing of Brucella abortus uncovers essential genes for growth in vitro and inside macrophages

Sternon, J-F., Godessart, P., Gonçalves de Freitas, R., Van der Henst, M., Poncin, K., Francis, N., Willemart, K., Christen, M., Christen, B., Letesson, J-J. & De Bolle, X., 1 Aug 2018, In : Infection and Immunity. 86, 8, e00312-18.

Research output: Contribution to journalArticle

Brucella abortus
Essential Genes
Macrophages
Growth
Genes
2017

Brucella genital tropism: What's on the menu

Letesson, J. J., Barbier, T., Zúñiga-Ripa, A., Godfroid, J., De Bolle, X. & Moriyón, I., 28 Mar 2017, In : Frontiers in Microbiology. 8, MAR, 506.

Research output: Contribution to journalComment/debate

CtrA Controls Cell Division and Outer Membrane Composition of the Pathogen Brucella abortus

Francis, N., Poncin, K., Fioravanti, A., Vassen, V., Willemart, K., Ong, T. A. P., Rappez, L., Letesson, J-J., Biondi, E. G. & De Bolle, X., Mar 2017, In : Molecular Microbiology. 103, 5, p. 780-797 18 p.

Research output: Contribution to journalArticle

Brucella abortus
Cell Division
Alphaproteobacteria
Regulon
Membranes
44 Downloads (Pure)

Erythritol availability in bovine, murine and human models highlights a potential role for the host aldose reductase during Brucella infection

Barbier, T., Machelart, A., Zúñiga-Ripa, A., Plovier, H., Hougardy, C., Lobet, E., Willemart, K., Muraille, E., De Bolle, X., Van Schaftingen, E., Moriyón, I. & Letesson, J. J., 13 Jun 2017, In : Frontiers in Microbiology. 8, JUN, 1088.

Research output: Contribution to journalArticle

Open Access
File
Erythritol
Aldehyde Reductase
Brucella
Infection
Pentoses

OXA-427, a new plasmid-borne carbapenem-hydrolysing class D β-lactamase in Enterobacteriaceae

Bogaerts, P., Naas, T., Saegeman, V., Bonnin, R. A., Schuermans, A., Evrard, S., Bouchahrouf, W., Jove, T., Tande, D., de Bolle, X., Huang, T. D., Dortet, L. & Glupczynski, Y., 1 Sep 2017, In : The Journal of antimicrobial chemotherapy. 72, 9, p. 2469-2477 9 p.

Research output: Contribution to journalArticle

Carbapenems
Enterobacteriaceae
Plasmids
Aeromonas
Ceftazidime
2016
28 Downloads (Pure)

Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains

Suárez-Esquivel, M., Ruiz-Villalobos, N., Castillo-Zeledón, A., Jiménez-Rojas, C., Roop, R. M., Comerci, D. J., Barquero-Calvo, E., Chacón-Díaz, C., Caswell, C. C., Baker, K. S., Chaves-Olarte, E., Thomson, N. R., Moreno, E., Letesson, J. J., De Bolle, X. & Guzmán-Verri, C., 2016, In : Frontiers in Microbiology. 7, SEP

Research output: Contribution to journalArticle

Open Access
File
Brucella abortus
Brucella
Brucellosis
Genome
Host-Pathogen Interactions
Open Access
Proteobacteria
Glutamate Dehydrogenase
glutamate dehydrogenase
Cell Division
NAD
20 Downloads (Pure)

Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus

Ronneau, S., Petit, K., De Bolle, X. & Hallez, R., 25 Apr 2016, In : Nature Communications. 7, 11423.

Research output: Contribution to journalArticle

Open Access
File
Caulobacter crescentus
deprivation
glutamine
Starvation
Glutamine
2015
24 Downloads (Pure)

A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus

Beaufay, F., Coppine, J., Mayard, A., Laloux, G., De Bolle, X. & Hallez, R., 2 Jul 2015, In : The EMBO journal. 34, 13, p. 1786-1800 15 p.

Research output: Contribution to journalArticle

Open Access
File
Caulobacter crescentus
Glutamate Dehydrogenase
Metabolism
Cell Division
NAD

Brucella abortus Cell Cycle and Infection Are Coordinated

De Bolle, X., Crosson, S., Matroule, J-Y. & Letesson, J-J., 2015, In : Trends in Microbiology.

Research output: Contribution to journalArticle

Brucella abortus
Cell Cycle
Caulobacter crescentus
Bacteria
Infection
2014
33 Downloads (Pure)

G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus

Deghelt, M., Mullier, C., Sternon, J-F., Francis, N., Laloux, G., Dotreppe, D., Van der Henst, C., Jacobs-Wagner, C., Letesson, J-J. & De Bolle, X., 2014, In : Nature Communications. 5, p. 4366 11 p.

Research output: Contribution to journalArticle

Open Access
File
Brucella abortus
pathogens
Pathogens
Cells
Bacteria
4 Downloads (Pure)

Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in escherichia coli

Nicolaes, V., Hajjaji, H. E., Davis, R. M., Van der Henst, C., Depuydt, M., Leverrier, P., Aertsen, A., Haufroid, V., de Choudens, S. O., De Bolle, X., Ruiz, N. & Collet, J. F., 1 Jan 2014, In : Journal of Bacteriology. 196, 2, p. 300-309 10 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Membrane Proteins
Escherichia coli
Rubredoxins
Iron

On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus

Letesson, J-J., De Bolle, X. & Deghelt, M., 2014, In : microbial cell. 1, 10, p. 346-348

Research output: Contribution to journalArticle

Open Access
34 Downloads (Pure)
Open Access
File
Brucella melitensis
Brucella abortus
Autophagy
Fibroblasts
Brucella

The quest for a true One Health perspective of brucellosis

Godfroid, J., De bolle, X., Roop, R. M., O'Callaghan, D., Tsolis, R. M., Baldwin, C., Santos, R. L., McGiven, J., Olsen, S., Nymo, I. H., Larsen, A., Al Dahouk, S. & Letesson, J. J., Aug 2014, In : OIE Revue Scientifique et Technique. 33, 2, p. 521-538 18 p.

Research output: Contribution to journalArticle

brucellosis
Brucella
zoonoses
human diseases
Biological Sciences
2013
34 Downloads (Pure)
Open Access
File
Brucella melitensis
Sinorhizobium meliloti
Detergents
Alphaproteobacteria
Lipid A
26 Downloads (Pure)

BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suis

Ruiz-Ranwez, V., Posadas, D. M., Van der Henst, C., Estein, S. M., Arocena, G. M., Abdian, P. L., Martín, F. A., Sieira, R., De Bolle, X. & Zorreguieta, A., 1 Mar 2013, In : Infection and Immunity. 81, 3, p. 996-1007 12 p.

Research output: Contribution to journalArticle

Open Access
File
Brucella suis
Adhesives
Virulence
Brucella
Genome
53 Downloads (Pure)

Innate immune recognition of flagellin limits systemic persistence of Brucella

Terwagne, M., Ferooz, J., Rolán, H. G., Sun, Y. H., Atluri, V., Xavier, M. N., Franchi, L., Núñez, G., Legrand, T., Flavell, R. A., De Bolle, X., Letesson, J-J. & Tsolis, R. M., 1 Jun 2013, In : Cellular microbiology. 15, 6, p. 942-960 19 p.

Research output: Contribution to journalArticle

Open Access
File
Flagellin
Brucella
Infection
Brucella melitensis
Inflammasomes
84 Downloads (Pure)

Quorum sensing and self-quorum quenching in the intracellular pathogen Brucella melitensis

Terwagne, M., Mirabella, A., Lemaire, J., Deschamps, C., De Bolle, X. & Letesson, J-J., 11 Dec 2013, In : PLoS ONE. 8, 12, e82514.

Research output: Contribution to journalArticle

Open Access
File
Acyl-Butyrolactones
Brucella melitensis
homoserine
Quorum Sensing
quorum sensing

The Brucella pathogens are polarized bacteria

Van der Henst, C., de Barsy, M., Zorreguieta, A., Letesson, J-J. & De Bolle, X., 1 Dec 2013, In : Microbes and infection : a journal on infectious agents and host defenses. 15, 14-15, p. 998-1004 7 p.

Research output: Contribution to journalArticle

Brucella
Bacteria
Brucellosis
Zoonoses
Growth
2012

A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells

de Barsy, M., Mirabella, A., Letesson, J-J. & De Bolle, X., 2012, In : Microbiology. 158, Pt 10, p. 2610-8 9 p.

Research output: Contribution to journalArticle

Brucella abortus
Brucella
HeLa Cells
Endoplasmic Reticulum
Calnexin
7 Downloads (Pure)

Polar growth in the Alphaproteobacterial order Rhizobiales

Brown, P. J. B., de Pedro, M. A., Kysela, D. T., Van der Henst, C., Kim, J., De Bolle, X., Fuqua, C. & Brun, Y. V., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1697-701 5 p.

Research output: Contribution to journalArticle

Bacteria
Growth
Peptidoglycan
Ochrobactrum anthropi
Sinorhizobium meliloti
6 Downloads (Pure)
Brucella melitensis
Porins
Brucella
Membrane Proteins
Membranes

Small GTPases and Brucella entry into the endoplasmic reticulum

de Bolle, X., Letesson, J-J. & Gorvel, J-P., 2012, In : Biochemical Society transactions. 40, 6, p. 1348-52 5 p.

Research output: Contribution to journalArticle

Brucella
Monomeric GTP-Binding Proteins
Endoplasmic Reticulum
Bacteria
Glyceraldehyde-3-Phosphate Dehydrogenases
15 Downloads (Pure)

Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase

Nkengfac, B., Pouyez, J., Bauwens, E., Vandenhaute, J., Letesson, J-J., Wouters, J. & De Bolle, X., 17 Aug 2012, In : BMC biochemistry. 13, 1, p. 16 16.

Research output: Contribution to journalArticle

Open Access
File
Brucella abortus
GTP Phosphohydrolases
Structural analysis
Substitution reactions
Proteins
17 Downloads (Pure)

The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus

Van der Henst, C., Beaufay, F., Mignolet, J., Didembourg, C., Colinet, J., Hallet, B., Letesson, J-J. & De Bolle, X., 2012, In : Journal of Bacteriology. 194, 19, p. 5305-14 10 p.

Research output: Contribution to journalArticle

Open Access
File
Alphaproteobacteria
Brucella abortus
Cell Cycle Checkpoints
Amino Acids
Cell Division

The two-component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength

Mirabella, A., Yañez Villanueva, R-M., Delrue, R-M., Uzureau, S., Zygmunt, M. S., Cloeckaert, A., De Bolle, X. & Letesson, J-J., 2012, In : Microbiology. 158, Pt 10, p. 2642-51 10 p.

Research output: Contribution to journalArticle

Brucella melitensis
Brucella
Osmolar Concentration
Symporters
Computational Biology
2011

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2

de Barsy, M., Jamet, A., Filopon, D., Nicolas, C., Laloux, G., Rual, J-F., Muller, A., Twizere, J-C., Nkengfac, B., Vandenhaute, J., Hill, D. E., Salcedo, S. P., Gorvel, J-P., Letesson, J-J. & De Bolle, X., 1 Jul 2011, In : Cellular microbiology. 13, 7, p. 1044-58 15 p.

Research output: Contribution to journalArticle

Brucella
Monomeric GTP-Binding Proteins
Brucella abortus
Vacuoles
HeLa Cells

Is the autophagic pathway implicated in the replication of Brucella abortus ?

Goffin, E., De Bolle, X., Letesson, J-J., Van der Henst, C., de Barsy, M., Raes, M., Arnould, T., Jadot, M. & Hamer, I., 2011.

Research output: Contribution to conferencePoster

RpoE1, an extracytoplasmic function sigma factor, is a repressor of the flagellar system in Brucella melitensis

Ferooz, J., Lemaire, J., Delory, M., De Bolle, X. & Letesson, J-J., 1 May 2011, In : Microbiology. 157, 5, p. 1263-8 6 p.

Research output: Contribution to journalArticle

Brucella melitensis
Sigma Factor
Mutation
Genes
Genome
37 Downloads (Pure)
Open Access
File
Acyl-CoA Dehydrogenase
Brucella abortus
Alkylation
Constriction
Proteins
2010

Brucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilm

Godefroid, M., Uzureau, S., Mirabella, A., De Bolle, X., Letesson, J-J., Svensson, M. V., Widmalm, G., Cambier, P. & Van Cutsem, P., 1 Aug 2010, In : FEMS Immunology and Medical Microbiology. 59, 3, p. 364-377 14 p.

Research output: Contribution to journalArticle

Brucella melitensis
Mannans
Biofilms
Extracellular Matrix
Quorum Sensing
55 Downloads (Pure)

Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen brucella melitensis

Dozot, M., Nicolas, C., Copin, R., de Bolle, X., Letesson, J-J., Poncet, S., Bouraoui, H., Mazé, A. & Deutscher, J., 1 Jan 2010, In : PLoS ONE. 5, 9, p. 1-16 16 p.

Research output: Contribution to journalArticle

Open Access
File
Brucella melitensis
Pathogens
phosphotransferases (kinases)
Phosphotransferases
pathogens

Global analysis of quorum sensing targets in the intracellular pathogen brucella melitensis 16 M

Uzureau, S., Lemaire, J., Delaive, E., Dieu, M., Gaigneaux, A., Raes, M., De Bolle, X. & Letesson, J-J., 4 Jun 2010, In : Journal of Proteome Research. 9, 6, p. 3200-3217 18 p.

Research output: Contribution to journalArticle

Brucella melitensis
Quorum Sensing
Brucella
Pathogens
Bacteria
76 Downloads (Pure)
Open Access
File
31 Downloads (Pure)
Open Access
File
Brucella abortus
Inclusion Bodies
Escherichia coli
Recombinant Proteins
Bacterial Structures
1 Downloads (Pure)

PdhS, an old-pole-localized histidine kinase, recruits the fumarase FumC in Brucella abortus

Mignolet, J., Van der Henst, C., Nicolas, C., Deghelt, M., Dotreppe, D., Letesson, J-J. & De Bolle, X., 2010, In : J Bacteriol. 192, 12, p. 3235-9 5 p.

Research output: Contribution to journalArticle

Open Access
Fumarate Hydratase
Brucella abortus
Caulobacter crescentus
Sinorhizobium meliloti
Yeasts
2009

Correlations between carbon metabolism and virulence in Bacteria

Poncet, S., Milohanic, E., Mazé, A., Nait Abdallah, J., Aké, F., Larribe, M., Deghmane, A. E., Taha, M. K., Dozot, M., De Bolle, X., Letesson, J. J. & Deutscher, J., 1 Jan 2009, Bacterial Sensing and Signaling. S. Karger AG, p. 88-102 15 p. (Contributions to Microbiology; vol. 16).

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Virulence
Carbon
Catabolite Repression
Bacteria
Phosphotransferases
2008

Intracellular rescuing of a B. melitensis 16M virB mutant by co-infection with a wild type strain

Nijskens, C., Copin, R., De Bolle, X. & Letesson, J-J., 2008, In : Microbial pathogenesis. 45, p. 134-141 8 p.

Research output: Contribution to journalArticle

2007

FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae

Léonard, S., Ferooz, J., Haine, V., Danese, I., Fretin, D., Tibor, A., De Walque, S., De Bolle, X. & Letesson, J. J., 1 Jan 2007, In : J. Bacteriol. 189, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

Rhizobiaceae
Brucella melitensis
Proteobacteria
Genes
Gene Expression
Brucella abortus
replication origin
Replication Origin
Brucella melitensis biovar Abortus
epitopes

Mutations of the Quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis

Bonnot, S., Godefroid, M., Deschamps, C., Lemaire, J., De Bolle, X. & Letesson, J-J. (ed.), 2007, In : J. Bacteriol. 189, p. 6035-6047 13 p.

Research output: Contribution to journalArticle