Séverine Robert

  • 809 Citations
  • 15 h-Index
20012014
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Research Output 2004 2014

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Étude du mode d'interaction de coumarines avec la thrombine

Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Évaluation biologique de dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2005
Factor Xa
Thrombin
hydrazine
Coumarins
Chymotrypsin

Évaluation biologique de coumarines en tant qu'inhibiteurs du complexe facteur tissulaire/facteur VIIa

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Structure-based design of coumarins as potent thrombin inhibitors

Frédérick, R., Robert, S., Charlier, C., De Ruyck, J., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2006

Développement d'inhibiteurs sélectifs de thrombine : optimisation du substituant en position P1

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2006, Abstract Book-20èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Séminaires de Biochimie Humaine

Robert, S., Rolin, S. & Dogné, J-M., 2006

Research output: Other contribution

2007

Erratum/ The bending vibrations in 12C2H2: Global vibration-rotation analysis (Molecular Physics (2007) 105:5 (559-568))

Robert, S., Herman, M., Vander Auwera, J., Di Lonardo, G., Fusina, L., Blanquet, G., Lepère, M. & Fayt, A., 1 Jul 2007, In : Molecular physics. 105, 13-14, p. 2009 1 p.

Research output: Contribution to journalArticle

Exercices de Technologie Pharmaceutique

Robert, S. & Dogné, J-M., 2007

Research output: Other contribution

Le profil d'activité de thrombine: un puissant test de criblage ex vivo pour le développement d'agents anticoagulants

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Benzopyrans
Thrombin
Derivatives
Factor Xa
Chymotrypsin

Microwave assisted medicinal chemistry: application to the synthesis of coumarins and cyclodextrins

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Nouvelles coumarines 3-carboxamides en tant qu'inhibiteurs de facteur XIIa

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moiety in the 3-position as new anticoagulant drugs

Robert, S., Frédérick, R., Masereel, B., Dogné, J-M. & Pochet, L., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

The bending vibrations in 12C2H2: global vibration-rotation analysis: Global vibration-rotation analysis

Robert, S., Herman, M., Vander Auwera, J., Di Lonardo, G., Fusina, L., Blanquet, G., Lepere, M. & Fayt, A., 1 Mar 2007, In : Molecular physics. 105, 5-7, p. 559-568 10 p.

Research output: Contribution to journalArticle

bending vibration
Vibration
Hamiltonians
vibration
Dipole moment

Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, In : Journal of Thrombosis and Haemostasis. 5, Suppl. 2

Research output: Contribution to journalLiterature review

Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-XXIst Congress of the International Society on Thrombosis and Haemostasis.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Thrombin activity profile: a rapid, reliable and relevant ex vivo screening test for the development of anticoagulant drugs

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2008

A potential new drug delivery system for cancer therapy: biotin-labelled beta-cyclodextrin.

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Contribution of platelet microparticles assay to type II HIT

Mullier, F., Bailly, N., Cornet, Y., Robert, S., Dogné, J-M. & Chatelain, B., 2008, Abstract Book-Association Belge de Cytologie Analytique 2008 (ABCA/BVAC).

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Design, synthesis and pharmacological evaluation of novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Microwave assisted medicinal chemistry : application to the synthesis of coumarins and cyclodextrins

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2008, In : Chimie nouvelle. 98, p. 25-25 1 p.

Research output: Contribution to journalLiterature review

Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Drugs of the future. 33, suppl A

Research output: Contribution to journalLiterature review

Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Journal of Medicinal Chemistry. 51, p. 3077-3081 5 p.

Research output: Contribution to journalArticle

2009

Accurate quantification of microparticles by flow cytometry: important issues.

Mullier, F., Dogné, J-M., Bailly, N., Cornet, Y., Robert, S. & Chatelain, B., 2009, In : Journal of Thrombosis and Haemostasis. 7, 2

Research output: Contribution to journalLiterature review

Contribution of Platelet Microparticles Generation Assay to the Diagnosis of Type II Heparin-induced Thrombocytopenia.

Mullier, F., Bailly, N., Cornet, Y., Dubuc, E., Robert, S., Osselaer, J-C., Chatelain, C. & Chatelain, B., 2009, Abstract Book - Annual Meeting of Belgian Society on Thrombosis and Haemostasis.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Effects of leaf extracts from Croton zambesicus on hemostasis.

Robert, S., Baccelli, C., Devel, P., Dogné, J-M. & Quetin-Leclercq, J., 2009, Abstract book - 23èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

1 Downloads (Pure)

Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis

Decrem, Y., Rath, G., Blasioli, V., Cauchie, P., Robert, S., Beaufays, J., Frère, J. M., Feron, O., Dogné, J. M., Dessy, C., Vanhamme, L. & Godfroid, E., 26 Oct 2009, In : Journal of Experimental Medicine. 206, 11, p. 2381-2395 15 p.

Research output: Contribution to journalArticle

Open Access
File
Ixodes
Ticks
Hemostasis
Thrombosis
Blood Coagulation

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2009, In : Pharmacological Research. 59, 3, p. 160-166 7 p.

Research output: Contribution to journalArticle

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2009, Abstract book - Annual Meeting of Belgian Society on Thrombosis and Haemostasis.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Matériel et manipulations en labos pharmaceutiques

Robert, S., Devel, P., Deglim, J., Masereel, B., Sovet, P., Lepièce, D. & Fraiture, M. N., 2009

Research output: Non-textual formDigital or Visual Products

Potential nanotoxicity in blood : Effects of engineered nanoparticles on human blood constituents

Laloy, J., Marbehant, C., Robert, S., Mullier, F., Chatelain, B., Dogné, J-M., Toussaint, O., Masereel, B. & Rolin, S., 2009, In : Nanofac 2009.

Research output: Contribution to journalMeeting abstract

2010

Comparison of Laboratory Assays to Measure Rivaroxaban and Dabigatran

Robert, S., Mullier, F., Mekouar, H., Polet, F., Douxfils, J., Biot, F., Lambert, M-C., Baudar, J., Devel, P., Chatelain, C. J. & Dogne, J-M., 2010, Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 3332. .

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Comparison of Laboratory Assays to Measure Rivaroxaban and Dabigatran

Robert, S., Mullier, F., Mekouar, H., Polet, F., Douxfils, J., Biot, F., Lambert, M-C., Baudar, J., Devel, P., Chatelain, C. J. & Dogne, J-M., 2010.

Research output: Contribution to conferencePoster

Contribution of platelet microparticles generation assay to the diagnosis of type II heparin-induced thrombocytopenia

Mullier, F., Bailly, N., Cornet, Y., Dubuc, E., Robert, S., Osselaer, J-C., Chatelain, C., Dogné, J-M. & Chatelain, B., Jun 2010, In : Thrombosis and Haemostasis. 103, 6, p. 1277-81 5 p.

Research output: Contribution to journalArticle

Contribution of Platelet Microparticles Generation Assay to the Diagnosis of Type II Heparin-induced Thrombocytopenia.

Mullier, F., Bailly, N., Cornet, Y., Robert, S., Dubuc, E., Osselaer, J-C., Chatelain, C., Dogné, J-M. & Chatelain, B., 2010, In : Thrombosis and Haemostasis. 103, 6, p. 1277-1281 5 p.

Research output: Contribution to journalArticle

Effects of leaf extracts from Croton zambesicus Müell. Arg. on hemostasis

Robert, S., Baccelli, C., Devel, P., Dogné, J-M. & Quetin-Leclercq, J., 21 Apr 2010, In : Journal of Ethnopharmacology. 128, 3, p. 641-8 8 p.

Research output: Contribution to journalArticle

Croton
Hemostasis
Euphorbiaceae
Benin
Hypertension

Evaluation of Anticoagulant Drugs with TF-Induced Thrombin Generation: An In Vitro comparative Study In Platelet-Rich Plasma (PRP) Versus Platelet-Poor Plasma (PPP)

Robert, S., Mullier, F., Lufin, N., Devel, P., Chatelain, B. & Dogne, J-M., 2010, BLOOD. Vol. 116. p. 1365-1366 2 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Implication of tissue-factor bearing microparticles in thrombosis associated with breast cancer

Mullier, F., Gheldof, D., Robert, S., Bailly, N., Devel, P., Michiels, C., Doyen, C., Christian, C., Chatelain, B. & Dogné, J-M., 2010, In : Belgian Society of Clinical Biology, Anvers, October 16th; 2010.

Research output: Contribution to journalLiterature review