Projects per year
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Projects 2000 2013
- 5 Finished
HOPE4PD: HOPE4PD
Masereel, B., Frederick, R., Dolusic, E., Combalbert, J., Klitgaard, H., schiffmann, S. & May, H.
31/03/11 → 30/09/13
Project: Research
CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer
Masereel, B., Wouters, J., Dolusic, E., Frederick, R., Pouyez, J., Van den Eynde, B., Frère, J. M., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.
1/04/08 → 31/03/12
Project: Research
Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway
1/10/07 → 30/09/10
Project: Research
COUMARINE: Conception and synthesis of inhibitors of serine proteases
Masereel, B., Pochet, L., Frederick, R. & Robert, S.
1/01/01 → 1/02/06
Project: PHD
Synthesis and biochemical and biophysical characterization of the properties of type B monoamine oxidase inhibitors
1/09/00 → 31/08/01
Project: Research
Research Output 2001 2019
Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation
Spillier, Q., Vertommen, D., Ravez, S., Marteau, R., Thémans, Q., Corbet, C., Feron, O., Wouters, J. & Frédérick, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 4737.Research output: Contribution to journal › Article
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio
Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.Research output: Contribution to journal › Article
Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer
Brisson, L., Bański, P., Sboarina, M., Dethier, C., Danhier, P., Fontenille, M. J., Van Hée, V. F., Vazeille, T., Tardy, M., Falces, J., Bouzin, C., Porporato, P. E., Frédérick, R., Michiels, C., Copetti, T. & Sonveaux, P., 2016, In : Cancer Cell. 30, 3, p. 418-431 14 p.Research output: Contribution to journal › Article
3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties
Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.Research output: Contribution to journal › Article
Design of new small molecular weight inhibitors of FXIIa
Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.Research output: Contribution to conference › Poster
Datasets
CCDC 813565: Experimental Crystal Structure Determination
Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012
DOI: 10.5517/ccw9l1s, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l1s&sid=DataCite
Dataset
CCDC 282947: Experimental Crystal Structure Determination
Aschenbach, L. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2007
DOI: 10.5517/cc9hfbj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc9hfbj&sid=DataCite
Dataset
CCDC 282948: Experimental Crystal Structure Determination
Aschenbach, L. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2007
DOI: 10.5517/cc9hfck, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc9hfck&sid=DataCite
Dataset
CCDC 813566: Experimental Crystal Structure Determination
Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012
DOI: 10.5517/ccw9l2t, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l2t&sid=DataCite
Dataset
CCDC 757790: Experimental Crystal Structure Determination
Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/cctfjvl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctfjvl&sid=DataCite
Dataset
Activities 1998 2007
Discovery of new PI3K inhibitors using virtual screening Phosphoinositide-3-kinase (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110alpha
Raphaël Frederick (Contributor)Activity: Participating in or organising an event types › Participation in workshop, seminar, course
The Maurice Wilkins Centre for Molecular Biodiscovery Research Symposium
Raphaël Frederick (Contributor)Activity: Participating in or organising an event types › Participation in conference
TRIPOS TRAINING WORKSHOP Ligand docking
Raphaël Frederick (Participant)Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Post-Doc Stay at the "Auckland Cancer Society Research Centre" (University of Auckland, Auckland, New Zealand
Raphaël Frederick (Contributor)Activity: Participating in or organising an event types › Participation in conference
TRIPOS TRAINING WORKSHOP Receptor-Ligand Modeling for New Modeller
Raphaël Frederick (Participant)Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Thesis
Conception, synthèse et étude d’inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer
Author: Moineaux, L., 30 Jan 2012Supervisor: Wouters, J. (Supervisor), Lanners, S. (President), Masereel, B. (Jury), Galleni, M. (External person) (Jury) & Frederick, R. (Jury)
Student thesis: Doc types › Doctor of Sciences
Rational design, synthesis, molecular modeling and evaluation of β-carboline and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors
Author: Reniers, J., 4 Oct 2011Supervisor: Wouters, J. (Supervisor), Frederick, R. (Jury), Michiels, C. (Jury), Vincent, S. (President) & Kiss, R. (External person) (Jury)
Student thesis: Doc types › Doctor of Sciences
Synthèse d'inhibiteurs d'indoleamine-2,3-dioxygenases (IDO et TDO) deux enzymes dont les propriétés immunosuppressives en font des cibles majeures pour le traitement du cancer
Author: Modaffari, S., 2010Supervisor: Frederick, R. (Supervisor) & Dolusic, E. (Jury)
Student thesis: Master types › Master in Chemistry
Synthèse et caractérisation structurale de nouveaux inhibiteurs de la MAO de type B
Author: Frédérick, R., 2000Supervisor: Durant, F. (Supervisor)
Student thesis: Master types › Master in Chemistry
Synthèse et étude de coumarines 3,6-disubstituées en tant qu'inhibiteurs de thrombine basés sur le mécanisme
Author: Frédérick, R., 2006Supervisor: Masereel, B. (Supervisor), Pochet, L. (Co-Supervisor), Dogne, J. (Jury), Krief, A. (Jury), Wouters, J. (Jury), Haemers, A. (External person) (Jury), Kraus, J. (External person) (Jury), Lambert, D. M. (External person) (Jury) & Lambert De Rouvroit, C. (Jury)
Student thesis: Doc types › Doctor of Sciences
Press / Media
Broadening TDO's base
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
23/02/12
1 item of Media coverage
Press/Media: Expert Comment
Une avancée considérable contre la cancer
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
7/02/12
1 item of Media coverage
Press/Media: Other
Cancer: Des chercheurs namurois innovent.
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
3/02/12
1 item of Media coverage
Press/Media: Other
AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER
Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet
2/02/12
1 item of Media coverage
Press/Media: Research
AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER
Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet
2/02/12
1 item of Media coverage
Press/Media: Research