Projects per year
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- 13 Similar Profiles
Indoleamine-Pyrrole 2,3,-Dioxygenase
Chemical Compounds
Tryptophan Oxygenase
Medicine & Life Sciences
Derivatives
Chemical Compounds
Monoamine Oxidase
Medicine & Life Sciences
Coumarins
Medicine & Life Sciences
Indoles
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Solubility
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2000 2013
- 5 Finished
HOPE4PD: HOPE4PD
Masereel, B., Frederick, R., Dolusic, E., Combalbert, J., Klitgaard, H., schiffmann, S. & May, H.
31/03/11 → 30/09/13
Project: Research
CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer
Masereel, B., Wouters, J., Dolusic, E., Frederick, R., Pouyez, J., Van den Eynde, B., Frère, J. M., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.
1/04/08 → 31/03/12
Project: Research
Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway
1/10/07 → 30/09/10
Project: Research
COUMARINE: Conception and synthesis of inhibitors of serine proteases
Masereel, B., Pochet, L., Frederick, R. & Robert, S.
1/01/01 → 1/02/06
Project: PHD
Synthesis and biochemical and biophysical characterization of the properties of type B monoamine oxidase inhibitors
1/09/00 → 31/08/01
Project: Research
Research Output 2001 2018
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio
Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.Research output: Contribution to journal › Article
Open Access
Anti-Infective Agents
Cytotoxicity
Cells
Peptidoglycan
Structure-Activity Relationship
Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer
Brisson, L., Bański, P., Sboarina, M., Dethier, C., Danhier, P., Fontenille, M. J., Van Hée, V. F., Vazeille, T., Tardy, M., Falces, J., Bouzin, C., Porporato, P. E., Frédérick, R., Michiels, C., Copetti, T. & Sonveaux, P., 2016, In : Cancer Cell. 30, 3, p. 418-431 14 p.Research output: Contribution to journal › Article
Autophagy
Lysosomes
Neoplasms
Lactic Acid
Glucose
3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties
Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.Research output: Contribution to journal › Article
Open Access
Harmine
Quantitative Structure-Activity Relationship
Solubility
Derivatives
Cells
Design of new small molecular weight inhibitors of FXIIa
Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.Research output: Contribution to conference › Poster
The 2,5-dichlorophenyl fragment as starting point in the design of new FXIIa inhibitors
Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 30 Jun 2015.Research output: Contribution to conference › Poster
Datasets
CCDC 282947: Experimental Crystal Structure Determination
Aschenbach, L. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2007
DOI: 10.5517/cc9hfbj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc9hfbj&sid=DataCite
Dataset
CCDC 757790: Experimental Crystal Structure Determination
Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/cctfjvl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctfjvl&sid=DataCite
Dataset
CCDC 794450: Experimental Crystal Structure Determination
Dolusic, E. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccvnpfl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvnpfl&sid=DataCite
Dataset
CCDC 794451: Experimental Crystal Structure Determination
Dolusic, E. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccvnpgm, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvnpgm&sid=DataCite
Dataset
CCDC 813565: Experimental Crystal Structure Determination
Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012
DOI: 10.5517/ccw9l1s, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l1s&sid=DataCite
Dataset
Activities 1998 2007
Discovery of new PI3K inhibitors using virtual screening Phosphoinositide-3-kinase (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110alpha
Raphaël Frederick (Contributor)3 Dec 2007
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
The Maurice Wilkins Centre for Molecular Biodiscovery Research Symposium
Raphaël Frederick (Contributor)17 Aug 2007
Activity: Participating in or organising an event types › Participation in conference
Post-Doc Stay at the "Auckland Cancer Society Research Centre" (University of Auckland, Auckland, New Zealand
Raphaël Frederick (Contributor)5 Mar 2006 → 6 Nov 2007
Activity: Participating in or organising an event types › Participation in conference
TRIPOS TRAINING WORKSHOP Ligand docking
Raphaël Frederick (Participant)3 Mar 2006
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
TRIPOS TRAINING WORKSHOP Receptor-Ligand Modeling for New Modeller
Raphaël Frederick (Participant)23 Feb 2006 → 24 Feb 2006
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Thesis
Conception, synthèse et étude d’inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer
Author: Moineaux, L., 30 Jan 2012Supervisor: Wouters, J. (Supervisor), Lanners, S. (President), Masereel, B. (Jury), Galleni, M. (External person) (Jury) & Frederick, R. (Jury)
Student thesis: Doc types › Doctor of Sciences
File
Conception, synthèse et évaluation biologique de coumarines en tant qu'inhibiteur de thrombine
Author: Frederick, R., 2003Supervisor: Pochet, L. (Jury)
Student thesis: Master types › Master in Pharmacy
Rational design, synthesis, molecular modeling and evaluation of β-carboline and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors
Author: Reniers, J., 4 Oct 2011Supervisor: Wouters, J. (Supervisor), Frederick, R. (Jury), Michiels, C. (Jury), Vincent, S. (President) & Kiss, R. (External person) (Jury)
Student thesis: Doc types › Doctor of Sciences
File
Synthèse de b-carbolines trisubstituées en tant que nouveaux agents antiprolifératifs
Author: Legrand, P., 2011Supervisor: Frederick, R. (Supervisor)
Student thesis: Master types › Master
Synthèse d'inhibiteurs d'indoleamine-2,3-dioxygenases (IDO et TDO) deux enzymes dont les propriétés immunosuppressives en font des cibles majeures pour le traitement du cancer
Author: Modaffari, S., 2010Supervisor: Frederick, R. (Supervisor) & Dolusic, E. (Jury)
Student thesis: Master types › Master in Chemistry
Press / Media
Broadening TDO's base
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
23/02/12
1 item of media coverage
Press/Media: Expert Comment
Une avancée considérable contre la cancer
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
7/02/12
1 item of media coverage
Press/Media: Other
Cancer: Des chercheurs namurois innovent.
Eduard Dolusic, Raphaël Frederick, Bernard Masereel & Johan Wouters
3/02/12
1 item of media coverage
Press/Media: Other
AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER
Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet
2/02/12
1 item of media coverage
Press/Media: Research
AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER
Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet
2/02/12
1 item of media coverage
Press/Media: Research