Raphaël Frederick

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Indoleamine-Pyrrole 2,3,-Dioxygenase Chemical Compounds

Tryptophan Oxygenase Medicine & Life Sciences

Derivatives Chemical Compounds

Monoamine Oxidase Medicine & Life Sciences

Coumarins Medicine & Life Sciences

Indoles Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Solubility Medicine & Life Sciences

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HOPE4PD: HOPE4PD

Masereel, B., Frederick, R., Dolusic, E., Combalbert, J., Klitgaard, H., schiffmann, S. & May, H.

31/03/11 → 30/09/13

Project: Research

CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer

Masereel, B., Wouters, J., Dolusic, E., Frederick, R., Pouyez, J., Van den Eynde, B., Frère, J. M., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.

1/04/08 → 31/03/12

Project: Research

Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway

Frederick, R.

1/10/07 → 30/09/10

Project: Research

COUMARINE: Conception and synthesis of inhibitors of serine proteases

Masereel, B., Pochet, L., Frederick, R. & Robert, S.

1/01/01 → 1/02/06

Project: PHD

Synthesis and biochemical and biophysical characterization of the properties of type B monoamine oxidase inhibitors

Durant, F. & Frederick, R.

1/09/00 → 31/08/01

Project: Research

Research Output 2001 2019

1291 Citations
21 h-Index
37 Article
23 Poster
16 Conference contribution
9 Literature review
2 More
- 1 Paper
- 1 Other contribution

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Spillier, Q., Vertommen, D., Ravez, S., Marteau, R., Thémans, Q., Corbet, C., Feron, O., Wouters, J. & Frédérick, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 4737.

Research output: Contribution to journal › Article

Open Access

Phosphoglycerate Dehydrogenase

Disulfiram

Alcoholism

Cysteine

Pharmaceutical Preparations

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journal › Article

Open Access

Anti-Infective Agents

Cytotoxicity

Cells

Peptidoglycan

Structure-Activity Relationship

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

Brisson, L., Bański, P., Sboarina, M., Dethier, C., Danhier, P., Fontenille, M. J., Van Hée, V. F., Vazeille, T., Tardy, M., Falces, J., Bouzin, C., Porporato, P. E., Frédérick, R., Michiels, C., Copetti, T. & Sonveaux, P., 2016, In : Cancer Cell. 30, 3, p. 418-431 14 p.

Research output: Contribution to journal › Article

Autophagy

Lysosomes

Neoplasms

Lactic Acid

Glucose

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journal › Article

Open Access

Harmine

Quantitative Structure-Activity Relationship

Solubility

Derivatives

Cells

Design of new small molecular weight inhibitors of FXIIa

Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.

Research output: Contribution to conference › Poster

Datasets

CCDC 757790: Experimental Crystal Structure Determination

Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011

DOI: 10.5517/cctfjvl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cctfjvl&sid=DataCite

Dataset

CCDC 813566: Experimental Crystal Structure Determination

Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012

DOI: 10.5517/ccw9l2t, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l2t&sid=DataCite

Dataset

CCDC 813564: Experimental Crystal Structure Determination

Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012

DOI: 10.5517/ccw9l0r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l0r&sid=DataCite

Dataset

CCDC 813565: Experimental Crystal Structure Determination

Frederick, R. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2012

DOI: 10.5517/ccw9l1s, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw9l1s&sid=DataCite

Dataset

CCDC 282948: Experimental Crystal Structure Determination

Aschenbach, L. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2007

DOI: 10.5517/cc9hfck, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc9hfck&sid=DataCite

Dataset

Activities 1998 2007

12 Participation in conference
3 Participation in workshop, seminar, course

Discovery of new PI3K inhibitors using virtual screening Phosphoinositide-3-kinase (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110alpha

Raphaël Frederick (Contributor)

3 Dec 2007

Activity: Participating in or organising an event types › Participation in workshop, seminar, course

The Maurice Wilkins Centre for Molecular Biodiscovery Research Symposium

Raphaël Frederick (Contributor)

17 Aug 2007

Activity: Participating in or organising an event types › Participation in conference

Post-Doc Stay at the "Auckland Cancer Society Research Centre" (University of Auckland, Auckland, New Zealand

Raphaël Frederick (Contributor)

5 Mar 2006 → 6 Nov 2007

Activity: Participating in or organising an event types › Participation in conference

TRIPOS TRAINING WORKSHOP Ligand docking

Raphaël Frederick (Participant)

3 Mar 2006

Activity: Participating in or organising an event types › Participation in workshop, seminar, course

TRIPOS TRAINING WORKSHOP Receptor-Ligand Modeling for New Modeller

Raphaël Frederick (Participant)

23 Feb 2006 → 24 Feb 2006

Activity: Participating in or organising an event types › Participation in workshop, seminar, course

Thesis

Conception, synthèse et étude d’inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Author: Moineaux, L., 30 Jan 2012

Supervisor: Wouters, J. (Supervisor), Lanners, S. (President), Masereel, B. (Jury), Galleni, M. (External person) (Jury) & Frederick, R. (Jury)

Student thesis: Doc types › Doctor of Sciences

File

Rational design, synthesis, molecular modeling and evaluation of β-carboline and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors

Author: Reniers, J., 4 Oct 2011

Supervisor: Wouters, J. (Supervisor), Frederick, R. (Jury), Michiels, C. (Jury), Vincent, S. (President) & Kiss, R. (External person) (Jury)

Student thesis: Doc types › Doctor of Sciences

File

Synthèse d'inhibiteurs d'indoleamine-2,3-dioxygenases (IDO et TDO) deux enzymes dont les propriétés immunosuppressives en font des cibles majeures pour le traitement du cancer

Author: Modaffari, S., 2010

Supervisor: Frederick, R. (Supervisor) & Dolusic, E. (Jury)

Student thesis: Master types › Master in Chemistry

Synthèse et caractérisation structurale de nouveaux inhibiteurs de la MAO de type B

Author: Frédérick, R., 2000

Supervisor: Durant, F. (Supervisor)

Student thesis: Master types › Master in Chemistry

Synthèse et étude de coumarines 3,6-disubstituées en tant qu'inhibiteurs de thrombine basés sur le mécanisme

Author: Frédérick, R., 2006

Supervisor: Masereel, B. (Supervisor), Pochet, L. (Co-Supervisor), Dogne, J. (Jury), Krief, A. (Jury), Wouters, J. (Jury), Haemers, A. (External person) (Jury), Kraus, J. (External person) (Jury), Lambert, D. M. (External person) (Jury) & Lambert De Rouvroit, C. (Jury)

Student thesis: Doc types › Doctor of Sciences