• 1853 Citations
  • 20 h-Index
19962020

Research output per year

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Research Output

2001

Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu'inhibiteurs de thrombine

Pochet, L., Doucet, C., Pirotte, B., Frédérick, R., Delarge, J., Reboud-Ravaux, M. & Masereel, B., 2001, Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie. Universitaires, P. & Namur, D. (eds.). p. 60

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2000

Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M. & Pirotte, B., 1 Jun 2000, In : Bioorganic and Medicinal Chemistry. 8, 6, p. 1489-1501 13 p.

Research output: Contribution to journalArticle

Inhibition of cellular invasion by 3-chlorophenyl 6-(acétoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate

Kempen, I., Pochet, L., Papapostolu, D., Bogetto, N., Doucet, C., Masereel, B., Foidart, J-M., Reboud-Ravaux, M., Frankenne, F. & Pirotte, B., 2000, In : European Journal of Physiology. 440, (78), p. R252

Research output: Contribution to journalLiterature review

1999

6-Substituted 2-Oxo-2H-1-benzopyran-3-carboxylic Acid as a Core Structure for Specific Inhibitors of Human Leukocyte Elastase

Doucet, C., Pochet, L., Thierry, N., Pirotte, B., Delarge, J. & Reboud-Ravaux, M., 1999, In : Journal of Medicinal Chemistry. 42, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

BM-519, a novel non-carboxylic thromboxane A2 antagonist

Masereel, B., Lacan, F., Fontaine, J., Nuhrich, A., Delarge, J., Pochet, L. & Dogné, J-M., 1999, In : Fundamental and Clinical Pharmacology. 13, (suppl 1), p. 191s

Research output: Contribution to journalLiterature review

Insulinotropic effect of new glibenclamide isosteres

Ouedraogo, R., Nguyen, QA., Antoine, M-H., Kane, C., Dunne, MJ., Pochet, L., Masereel, B. & Lebrun, P., 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, p. 625-631 7 p.

Research output: Contribution to journalArticle

Thromboxane A2 receptor antagonism in man and rat by a sulphonylcyanoguanidine (BM-144) and a sulphonylurea (BM-500)

Masereel, B., Damas, J., Fontaine, J., Lembège, M., Lacan, F., Nuhrich, A., Delarge, J., Pochet, L. & Dogné, J-M., 1999, In : Journal of Pharmacy and Pharmacology. 51, p. 695-701 7 p.

Research output: Contribution to journalArticle

1998

Design, synthesis, and anticonvulsant activity of 1-(pyrid-3- ylsulfonamido)-2-nitroethylenes

Masereel, B., Wouters, J., Pochet, L. & Lambert, D., 13 Aug 1998, In : Journal of Medicinal Chemistry. 41, 17, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Masereel, B., Ouedraogo, R., Dogne, J-M., Antoine, M-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J. & Lebrun, P., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Design of new potential hypoglycemic drugs

Masereel, B., De Tullio, P., Dogne, J-M., Lacan, F., Pirotte, B., Pochet, L., Somers, F. & Delarge, J., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Insulinotropic effect of glibenclamide isosteres

Nguyen, Q. A., Pochet, L., Ouedraogo, R., Dunne, M. J., Masereel, B., Lebrun, P. & Antoine, M-H., 1998, In : Fundamental and Clinical Pharmacology. 12, p. 307

Research output: Contribution to journalLiterature review

1997

Pharmacomodulation of torasemide led to original diuretic, neuroproptective anticonvulsant and antithrombotic drugs

Masereel, B., Dogné, J. M., Damas, J., Nuhrich, A., Varache-Lembège, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B. & Delarge, J., 1 Jul 1997, In : Journal de Pharmacie de Belgique. 52, 4, p. 157-158 2 p.

Research output: Contribution to journalShort survey

Pharmacomodulation studies of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs.

Masereel, B., Dogné, J-M., Nuhrich, A., Varache-Lembège, M., Fontaine, J., Pochet, L., Somers, F., de Tullio, P., Pirotte, B. & Delarge, J., 1997, In : Journal de Pharmacie de Belgique. 52, p. 157-158 2 p.

Research output: Contribution to journalArticle

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Masereel, B., Ouedraogo, R. B., Dogné, J-M., Antoine, M. H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J. & Lebrun, P. B., 1997, In : European Journal of Medicinal Chemistry. 32, 5, p. 453-456 4 p.

Research output: Contribution to journalArticle

Open Access
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1996

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers

Pirotte, B., Khelili, S., de Tullio, P., Fang, ZY., Ouedraogo, R., Antoine, M-H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J. & Lebrun, P., 1996, In : Journal de Pharmacie de Belgique. 51, (1), p. 117

Research output: Contribution to journalLiterature review

Anticonvulsant properties of 4-cycloalkyamino-pyrid-3-yl sulfonylureas and -thioureas

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J-F., de Tullio, P., Pirotte, B., Pochet, L., Khelili, S. & Delarge, J., 1996, In : Journal de Pharmacie de Belgique. 51, 3b, p. 17

Research output: Contribution to journalLiterature review

BM 34, an anticonvulsivant sulfonylurea with a phenytoin-like profile

Masereel, B., Lambert, D. M., Dogne, J-M., de Tullio, P., Pirotte, B., Pochet, L. & Delarge, J., 1996, In : J. Pharm. Belg.. 51, (1), p. 115

Research output: Contribution to journalLiterature review

Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: Significance of the «aromatic» nature of the novel ester-type coumarin for strong inhibitory activity.

Pochet, L., Doucet, C., Schynts, M., Thirry, N., Boggetto, N., Pirotte, B., Jiang, KY., Masereel, B., de Tullio, P., Delarge, J. & Reboud-Ravaux, M., 1996, In : Journal of Medicinal Chemistry. 1996, p. 2579-2585 7 p.

Research output: Contribution to journalArticle

First synthesis of 4-substituted-benzenesulfonylcyanoguanidines

Masereel, B., Lebrun, P., Dogné, J-M., de Tullio, P., Pirotte, B., Pochet, L., Diouf, O. & Delarge, J., 1996, In : Tetrahedron Letters. 37, p. 7253-7254 2 p.

Research output: Contribution to journalArticle

File
188 Downloads (Pure)

Nouveaux dérivés de l'acide 6-chloromé thyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu' inhibiteurs de protéases à sérine: étude des relations structure-activité explicant leur sélectivité d'action

Doucet, C., Pochet, L., Schynts, M., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., de Tullio, P., Delarge, J. & Reboud-Ravaux, M., 1996, In : Journal de Pharmacie de Belgique. 51, 3b, p. 18

Research output: Contribution to journalLiterature review