• 1853 Citations
  • 20 h-Index
19962020

Research output per year

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Research Output

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access

29ièmes journées Franco-Belges de Pharmacochimie: Meeting report

Frédérick, R., Pochet, L., De Tullio, P. & Dufrasne, F., 17 Nov 2015, In : Pharmaceuticals. 8, 4, p. 758-777 20 p.

Research output: Contribution to journalArticle

Open Access
File
154 Downloads (Pure)

3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Frédérick, R., Robert, S., Masereel, B., Pochet, L., Pirotte, B., Charlier, C., De Ruyck, J. & Wouters, J., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7592-7603 12 p.

Research output: Contribution to journalArticle

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
98 Downloads (Pure)

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers

Pirotte, B., Khelili, S., de Tullio, P., Fang, ZY., Ouedraogo, R., Antoine, M-H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J. & Lebrun, P., 1996, In : Journal de Pharmacie de Belgique. 51, (1), p. 117

Research output: Contribution to journalLiterature review

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

Kempen, I., Papapostolou, D., Thierry, N., Pochet, L., Counerotte, S., Masereel, B., Foidart, J-M., Reboud-Ravaux, M., Noel, A. & Pirotte, B., 2003, In : British Journal of Cancer. 88, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journalArticle

Open Access

6-Substituted 2-Oxo-2H-1-benzopyran-3-carboxylic Acid as a Core Structure for Specific Inhibitors of Human Leukocyte Elastase

Doucet, C., Pochet, L., Thierry, N., Pirotte, B., Delarge, J. & Reboud-Ravaux, M., 1999, In : Journal of Medicinal Chemistry. 42, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

Kempen, I., Hemmer, M., Counerotte, S., de Tullio, P., Pirotte, B., Pochet, L., Foidart, J-M., Blacher, S., Noël, A. & Frankenne, F., 1 Dec 2008, In : European Journal of Medicinal Chemistry. 43, 12, p. 2735-2750 16 p.

Research output: Contribution to journalArticle

An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants

Sennesael, A-L., Exner, T., Chatelain, B., Lessire, S., Larock, A-S., Vancraeynest, C., Pochet, L., Dogné, J-M., Spinewine, A., Mullier, F. & Douxfils, J., 1 Sep 2017, In : Thrombosis Research. 157, p. 29-37 9 p.

Research output: Contribution to journalArticle

An overview of inhibitors of Na+/H+ exchanger

Masereel, B., Pochet, L. & Laeckmann, D., 2003, In : European Journal of Medicinal Chemistry. 38, p. 547-554 8 p.

Research output: Contribution to journalArticle

Anticonvulsant properties of 4-cycloalkyamino-pyrid-3-yl sulfonylureas and -thioureas

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J-F., de Tullio, P., Pirotte, B., Pochet, L., Khelili, S. & Delarge, J., 1996, In : Journal de Pharmacie de Belgique. 51, 3b, p. 17

Research output: Contribution to journalLiterature review

A potential new drug delivery system for cancer therapy: biotin-labelled beta-cyclodextrin.

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Assessment of low plasma concentrations of apixaban in the periprocedural setting

Lessire, S., Dincq, A-S., Siriez, R., Pochet, L., Sennesael, A-L., Vornicu, O., Hardy, M., Deceuninck, O., Douxfils, J. & Mullier, F., 1 Aug 2020, In : International Journal of Laboratory Hematology. 42, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

Assessment of Small molecular weight inhibitors of the contact phase

Bouckaert, C., Zhu, S., Diamond, S. & Pochet, L., 27 May 2016.

Research output: Contribution to conferenceOther

Beta-cyclodextrin coupled to oxytocine: synthesis and pharmacological evaluation of a new potential drug carrier system

Bertolla, C., Rolin, S., Pochet, L. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Mullier, F., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Devroye, C., Guldenpfennig, M. & Douxfils, J., 2 Feb 2018.

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Devroye, C. & Guldenpfennig, M., 10 May 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

File
82 Downloads (Pure)

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Guldenpfennig, M. & Devroye, C., 18 Jul 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 24 Sep 2018.

Research output: Contribution to conferencePoster

File
13 Downloads (Pure)

Betrixaban: Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 5 Jul 2018, JTH - Journal of thrombosis and haemostasis: Research and Practice in thrombosis and haemostasis. Issue S1 ed. Vol. Volume 2. PB364

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban : Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, BJH - Belgian Journal of Hematology - Clinic: Abstracts - 33rd General Annual Meeting of the Belgian Hematology Society . p. 22 42 p. PP47

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, International Society for Laboratory Hematology: Abstracts.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Biotin tagged beta-cyclodextrin: a potential new drug targeting system for tumor therapy

Bertolla, C., Pochet, L. & Masereel, B., 2008, In : Drugs of the future. 33, suppl. A

Research output: Contribution to journalLiterature review

BM 34, an anticonvulsivant sulfonylurea with a phenytoin-like profile

Masereel, B., Lambert, D. M., Dogne, J-M., de Tullio, P., Pirotte, B., Pochet, L. & Delarge, J., 1996, In : J. Pharm. Belg.. 51, (1), p. 115

Research output: Contribution to journalLiterature review

BM-519, a novel non-carboxylic thromboxane A2 antagonist

Masereel, B., Lacan, F., Fontaine, J., Nuhrich, A., Delarge, J., Pochet, L. & Dogné, J-M., 1999, In : Fundamental and Clinical Pharmacology. 13, (suppl 1), p. 191s

Research output: Contribution to journalLiterature review

Capillary electrophoresis in the context of drug discovery

Farcaş, E., Pochet, L., Crommen, J., Servais, A. C. & Fillet, M., 10 Sep 2017, In : Journal of pharmaceutical and biomedical analysis. 144, p. 195-212 18 p.

Research output: Contribution to journalArticle

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

Farcaş, E., Hanson, J., Pochet, L. & Fillet, M., 30 Nov 2018, In : Analytica chimica acta. 1034, p. 214-222 9 p.

Research output: Contribution to journalArticle

coauthor on lecture: NOVEL DEVELOPMENT IN COUMARINS AS FXIIa INHIBITORS: IMPROVEMENT OF SOLUBILITY

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013, Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. Vol. OC05.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
File
34 Downloads (Pure)

Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors

Prevost, J. R. C., Kozlova, A., Es Saadi, B., Yildiz, E., Modaffari, S., Lambert, D. M., Pochet, L., Wouters, J., Dolušić, E. & Frédérick, R., 5 Dec 2018, In : Tetrahedron Letters. 59, 49, p. 4315-4319 5 p.

Research output: Contribution to journalArticle

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
59 Downloads (Pure)

COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke

Kraft, P., Schwarz, T., Stoll, G., Kleinschnitz, C. & Pochet, L., 15 Feb 2010, In : Experimental and Translational Stroke Medicine. 2, 1

Research output: Contribution to journalArticle

Coumarin and isocoumarin as serine protease inhibitors

Pochet, L., Frédérick, R. & Masereel, B., 1 Jan 2004, In : Current Pharmaceutical Design. 10, 30, p. 3781-3796 16 p.

Research output: Contribution to journalArticle

Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M. & Pirotte, B., 1 Jun 2000, In : Bioorganic and Medicinal Chemistry. 8, 6, p. 1489-1501 13 p.

Research output: Contribution to journalArticle

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Maresca, A., Temperini, C., Pochet, L., Masereel, B., Scozzafava, A. & Supuran, C., 2010, In : Journal of Medicinal Chemistry. 53, p. 335-344 10 p.

Research output: Contribution to journalArticle

Design, synthesis, and anticonvulsant activity of 1-(pyrid-3- ylsulfonamido)-2-nitroethylenes

Masereel, B., Wouters, J., Pochet, L. & Lambert, D., 13 Aug 1998, In : Journal of Medicinal Chemistry. 41, 17, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

Design, synthesis and pharmacological evaluation of novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Masereel, B., Ouedraogo, R., Dogne, J-M., Antoine, M-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J. & Lebrun, P., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Design and synthesis of thiosemicarbazides as inhibitors of Arginase I, a therapeutic target for anticancer immunotherapy

Colette, C., Vancraeynest, C., Serra, S., Pochet, L. & Frédérick, R., 2013, 2013 Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. p. 45

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Design of new potential hypoglycemic drugs

Masereel, B., De Tullio, P., Dogne, J-M., Lacan, F., Pirotte, B., Pochet, L., Somers, F. & Delarge, J., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Design of new small molecular weight inhibitors of FXIIa

Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.

Research output: Contribution to conferencePoster

Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis

Pochet, L., Bouckaert, C., Servais, A-C., Farcas, E., Bettonville, V. & Fillet, M., 1 Jan 2013, In : Talanta. 116, p. 719-725 7 p.

Research output: Contribution to journalArticle