• 1855 Citations
  • 20 h-Index
19962020

Research output per year

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Research Output

1996

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers

Pirotte, B., Khelili, S., de Tullio, P., Fang, ZY., Ouedraogo, R., Antoine, M-H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J. & Lebrun, P., 1996, In : Journal de Pharmacie de Belgique. 51, (1), p. 117

Research output: Contribution to journalLiterature review

Anticonvulsant properties of 4-cycloalkyamino-pyrid-3-yl sulfonylureas and -thioureas

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J-F., de Tullio, P., Pirotte, B., Pochet, L., Khelili, S. & Delarge, J., 1996, In : Journal de Pharmacie de Belgique. 51, 3b, p. 17

Research output: Contribution to journalLiterature review

BM 34, an anticonvulsivant sulfonylurea with a phenytoin-like profile

Masereel, B., Lambert, D. M., Dogne, J-M., de Tullio, P., Pirotte, B., Pochet, L. & Delarge, J., 1996, In : J. Pharm. Belg.. 51, (1), p. 115

Research output: Contribution to journalLiterature review

Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: Significance of the «aromatic» nature of the novel ester-type coumarin for strong inhibitory activity.

Pochet, L., Doucet, C., Schynts, M., Thirry, N., Boggetto, N., Pirotte, B., Jiang, KY., Masereel, B., de Tullio, P., Delarge, J. & Reboud-Ravaux, M., 1996, In : Journal of Medicinal Chemistry. 1996, p. 2579-2585 7 p.

Research output: Contribution to journalArticle

First synthesis of 4-substituted-benzenesulfonylcyanoguanidines

Masereel, B., Lebrun, P., Dogné, J-M., de Tullio, P., Pirotte, B., Pochet, L., Diouf, O. & Delarge, J., 1996, In : Tetrahedron Letters. 37, p. 7253-7254 2 p.

Research output: Contribution to journalArticle

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Nouveaux dérivés de l'acide 6-chloromé thyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu' inhibiteurs de protéases à sérine: étude des relations structure-activité explicant leur sélectivité d'action

Doucet, C., Pochet, L., Schynts, M., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., de Tullio, P., Delarge, J. & Reboud-Ravaux, M., 1996, In : Journal de Pharmacie de Belgique. 51, 3b, p. 18

Research output: Contribution to journalLiterature review

1997

Pharmacomodulation of torasemide led to original diuretic, neuroproptective anticonvulsant and antithrombotic drugs

Masereel, B., Dogné, J. M., Damas, J., Nuhrich, A., Varache-Lembège, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B. & Delarge, J., 1 Jul 1997, In : Journal de Pharmacie de Belgique. 52, 4, p. 157-158 2 p.

Research output: Contribution to journalShort survey

Pharmacomodulation studies of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs.

Masereel, B., Dogné, J-M., Nuhrich, A., Varache-Lembège, M., Fontaine, J., Pochet, L., Somers, F., de Tullio, P., Pirotte, B. & Delarge, J., 1997, In : Journal de Pharmacie de Belgique. 52, p. 157-158 2 p.

Research output: Contribution to journalArticle

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Masereel, B., Ouedraogo, R. B., Dogné, J-M., Antoine, M. H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J. & Lebrun, P. B., 1997, In : European Journal of Medicinal Chemistry. 32, 5, p. 453-456 4 p.

Research output: Contribution to journalArticle

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1998

Design, synthesis, and anticonvulsant activity of 1-(pyrid-3- ylsulfonamido)-2-nitroethylenes

Masereel, B., Wouters, J., Pochet, L. & Lambert, D., 13 Aug 1998, In : Journal of Medicinal Chemistry. 41, 17, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Masereel, B., Ouedraogo, R., Dogne, J-M., Antoine, M-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J. & Lebrun, P., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Design of new potential hypoglycemic drugs

Masereel, B., De Tullio, P., Dogne, J-M., Lacan, F., Pirotte, B., Pochet, L., Somers, F. & Delarge, J., 1998, In : Journal de Pharmacie de Belgique. 53

Research output: Contribution to journalLiterature review

Insulinotropic effect of glibenclamide isosteres

Nguyen, Q. A., Pochet, L., Ouedraogo, R., Dunne, M. J., Masereel, B., Lebrun, P. & Antoine, M-H., 1998, In : Fundamental and Clinical Pharmacology. 12, p. 307

Research output: Contribution to journalLiterature review

1999

6-Substituted 2-Oxo-2H-1-benzopyran-3-carboxylic Acid as a Core Structure for Specific Inhibitors of Human Leukocyte Elastase

Doucet, C., Pochet, L., Thierry, N., Pirotte, B., Delarge, J. & Reboud-Ravaux, M., 1999, In : Journal of Medicinal Chemistry. 42, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

BM-519, a novel non-carboxylic thromboxane A2 antagonist

Masereel, B., Lacan, F., Fontaine, J., Nuhrich, A., Delarge, J., Pochet, L. & Dogné, J-M., 1999, In : Fundamental and Clinical Pharmacology. 13, (suppl 1), p. 191s

Research output: Contribution to journalLiterature review

Insulinotropic effect of new glibenclamide isosteres

Ouedraogo, R., Nguyen, QA., Antoine, M-H., Kane, C., Dunne, MJ., Pochet, L., Masereel, B. & Lebrun, P., 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, p. 625-631 7 p.

Research output: Contribution to journalArticle

Thromboxane A2 receptor antagonism in man and rat by a sulphonylcyanoguanidine (BM-144) and a sulphonylurea (BM-500)

Masereel, B., Damas, J., Fontaine, J., Lembège, M., Lacan, F., Nuhrich, A., Delarge, J., Pochet, L. & Dogné, J-M., 1999, In : Journal of Pharmacy and Pharmacology. 51, p. 695-701 7 p.

Research output: Contribution to journalArticle

2000

Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M. & Pirotte, B., 1 Jun 2000, In : Bioorganic and Medicinal Chemistry. 8, 6, p. 1489-1501 13 p.

Research output: Contribution to journalArticle

Inhibition of cellular invasion by 3-chlorophenyl 6-(acétoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate

Kempen, I., Pochet, L., Papapostolu, D., Bogetto, N., Doucet, C., Masereel, B., Foidart, J-M., Reboud-Ravaux, M., Frankenne, F. & Pirotte, B., 2000, In : European Journal of Physiology. 440, (78), p. R252

Research output: Contribution to journalLiterature review

2001

Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu'inhibiteurs de thrombine

Pochet, L., Doucet, C., Pirotte, B., Frédérick, R., Delarge, J., Reboud-Ravaux, M. & Masereel, B., 2001, Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie. Universitaires, P. & Namur, D. (eds.). p. 60

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2002

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Wouters, J., Huygens, M., Pochet, L., Pirotte, B., Durant, F. & Masereel, B., 8 Apr 2002, In : Bioorganic and medicinal chemistry letters. 12, 7, p. 1109-1112 4 p.

Research output: Contribution to journalArticle

2003

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

Kempen, I., Papapostolou, D., Thierry, N., Pochet, L., Counerotte, S., Masereel, B., Foidart, J-M., Reboud-Ravaux, M., Noel, A. & Pirotte, B., 2003, In : British Journal of Cancer. 88, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

An overview of inhibitors of Na+/H+ exchanger

Masereel, B., Pochet, L. & Laeckmann, D., 2003, In : European Journal of Medicinal Chemistry. 38, p. 547-554 8 p.

Research output: Contribution to journalArticle

Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry

Pochet, L., Dieu, M., Frédérick, R., Murray, A-M., Kempen, I., Pirotte, B. & Masereel, B., 2003, In : Tetrahedron. 59, p. 4557-4561 5 p.

Research output: Contribution to journalArticle

2004

Coumarin and isocoumarin as serine protease inhibitors

Pochet, L., Frédérick, R. & Masereel, B., 1 Jan 2004, In : Current Pharmaceutical Design. 10, 30, p. 3781-3796 16 p.

Research output: Contribution to journalArticle

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as inhibitors of serine proteases of the coagulation cascade

Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Coumarins as serine protease inhibitors

Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, In : Drugs of the future. 29, A

Research output: Contribution to journalLiterature review

Étude du mode d'interaction de coumarines avec la thrombine

Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Évaluation biologique de dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Insight into the mode of action of coumarins as thrombin inhibitors

Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, In : Fundamental and Clinical Pharmacology. 18, p. 595

Research output: Contribution to journalLiterature review

Nouveaux dérivés cyanoguanidines de beta-cyclodextrines

Bertolla, C., Pochet, L. & Masereel, B., 2004, Abstract Book-18ème Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Synthesis of new cyanoguanidine beta-cyclodextrin derivatives

Bertolla, C., Pochet, L. & Masereel, B., 2004, Abstract Book-12th International Cyclodextrin Symposium.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2005

3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Frédérick, R., Robert, S., Masereel, B., Pochet, L., Pirotte, B., Charlier, C., De Ruyck, J. & Wouters, J., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7592-7603 12 p.

Research output: Contribution to journalArticle

Etude de fixation des coumarines sur l'alpha-chymotrypsine

Pochet, L. & Crespin, M., 2005

Research output: Other contribution

Évaluation biologique de coumarines en tant qu'inhibiteurs du complexe facteur tissulaire/facteur VIIa

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Modulators of the coagulation cascade: Focus and Recent Advances in Inhibitors of Tissue Factor, Factor VIIa and their complex

Frédérick, R., Pochet, L., Charlier, C. & Masereel, B., 2005, In : Current Medicinal Chemistry. 12, 4, p. 397-417 21 p.

Research output: Contribution to journalArticle

Purification de beta-cyclodextrines monofonctionnalisées par chromatographie échangeuse ionique : étude comparative

Bertolla, C., Murray, A-M., Pochet, L. & Masereel, B., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Structure-based design of coumarins as potent thrombin inhibitors

Frédérick, R., Robert, S., Charlier, C., De Ruyck, J., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2006

Développement d'inhibiteurs sélectifs de thrombine : optimisation du substituant en position P1

Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2006, Abstract Book-20èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Évaluation pharmacologique de la beta-cyclodextrin couplée à l'ocytocine en tant que nouveau véhicule moléculaire

Bertolla, C., Rolin, S., Pochet, L. & Masereel, B., 2006, Abstract Book - XXèmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Synthesis, molecular modelling and enzymatic evaluation of (±) 3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors

Gauthier, M-P., Michaux, C., Rolin, S., Vastersaegher, C., de Leval, X., Julémont, F., Pochet, L. & Masereel, B., 2006, In : Bioorganic and Medicinal Chemistry. 14, 4, p. 918-927 10 p.

Research output: Contribution to journalArticle

2007

Beta-cyclodextrin coupled to oxytocine: synthesis and pharmacological evaluation of a new potential drug carrier system

Bertolla, C., Rolin, S., Pochet, L. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Le profil d'activité de thrombine: un puissant test de criblage ex vivo pour le développement d'agents anticoagulants

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Mechanism-based thrombin inhibitors: Design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative

Frédérick, R., Robert, S., Charlier, C., Wouters, J., Masereel, B. & Pochet, L., 26 Jul 2007, In : Journal of Medicinal Chemistry. 50, 15, p. 3645-3650 6 p.

Research output: Contribution to journalArticle

Microwave assisted medicinal chemistry: application to the synthesis of coumarins and cyclodextrins

Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Nouveaux senseurs chimiques à base de beta-cyclodextrines comportant un motif coumarine. Synthèse, détermination structurale et étude des variations spectroscopiques

Bertolla, C., Pochet, L. & Masereel, B., 2007, Abstract Book-21ème Journées Franco-Belges de Pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution