• 1841 Citations
  • 20 h-Index
19962020

Research output per year

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Research Output

2020

Assessment of low plasma concentrations of apixaban in the periprocedural setting

Lessire, S., Dincq, A-S., Siriez, R., Pochet, L., Sennesael, A-L., Vornicu, O., Hardy, M., Deceuninck, O., Douxfils, J. & Mullier, F., 1 Aug 2020, In : International Journal of Laboratory Hematology. 42, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

Factor XII/XIIa inhibitors: Their discovery, development, and potential indications

DAVOINE, C., BOUCKAERT, C., Fillet, M. & POCHET, L., 15 Dec 2020, In : European Journal of Medicinal Chemistry. 208, 112753.

Research output: Contribution to journalReview article

Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting D-alanyl-D-alanine ligase in bacterio

Ameryckx, A., Pochet, L., Wang, G., Yildiz, E., Saadi, B. E., Wouters, J., Van Bambeke, F. & Frédérick, R., 15 Aug 2020, In : European Journal of Medicinal Chemistry. 200, 112444.

Research output: Contribution to journalArticle

2019
8 Downloads (Pure)
2018

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Guldenpfennig, M. & Devroye, C., 18 Jul 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

File
82 Downloads (Pure)

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 24 Sep 2018.

Research output: Contribution to conferencePoster

File
13 Downloads (Pure)

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Mullier, F., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Devroye, C., Guldenpfennig, M. & Douxfils, J., 2 Feb 2018.

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Devroye, C. & Guldenpfennig, M., 10 May 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 5 Jul 2018, JTH - Journal of thrombosis and haemostasis: Research and Practice in thrombosis and haemostasis. Issue S1 ed. Vol. Volume 2. PB364

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban : Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, BJH - Belgian Journal of Hematology - Clinic: Abstracts - 33rd General Annual Meeting of the Belgian Hematology Society . p. 22 42 p. PP47

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, International Society for Laboratory Hematology: Abstracts.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

Farcaş, E., Hanson, J., Pochet, L. & Fillet, M., 30 Nov 2018, In : Analytica chimica acta. 1034, p. 214-222 9 p.

Research output: Contribution to journalArticle

Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors

Prevost, J. R. C., Kozlova, A., Es Saadi, B., Yildiz, E., Modaffari, S., Lambert, D. M., Pochet, L., Wouters, J., Dolušić, E. & Frédérick, R., 5 Dec 2018, In : Tetrahedron Letters. 59, 49, p. 4315-4319 5 p.

Research output: Contribution to journalArticle

Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines

Sennesael, A. L., Panin, N., Vancraeynest, C., Pochet, L., Spinewine, A., Haufroid, V. & Elens, L., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 10514 10514.

Research output: Contribution to journalArticle

Enhancing action of positive allosteric modulators through the design of dimeric compounds

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, J. S. & Pirotte, B., 28 Jun 2018, In : Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

Research output: Contribution to journalArticle

2017

An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants

Sennesael, A-L., Exner, T., Chatelain, B., Lessire, S., Larock, A-S., Vancraeynest, C., Pochet, L., Dogné, J-M., Spinewine, A., Mullier, F. & Douxfils, J., 1 Sep 2017, In : Thrombosis Research. 157, p. 29-37 9 p.

Research output: Contribution to journalArticle

Capillary electrophoresis in the context of drug discovery

Farcaş, E., Pochet, L., Crommen, J., Servais, A. C. & Fillet, M., 10 Sep 2017, In : Journal of pharmaceutical and biomedical analysis. 144, p. 195-212 18 p.

Research output: Contribution to journalArticle

Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway

Bouckaert, C., Zhu, S., Govers-Riemslag, J. W. P., Depoorter, M., Diamond, S. L. & Pochet, L., 1 Sep 2017, In : Thrombosis Research. 157, p. 126-133 8 p.

Research output: Contribution to journalArticle

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin

Farcas, E., Bouckaert, C., Servais, A. C., Hanson, J., Pochet, L. & Fillet, M., 1 Sep 2017, In : Analytica chimica acta. 984, p. 211-222 12 p.

Research output: Contribution to journalArticle

2016

Assessment of Small molecular weight inhibitors of the contact phase

Bouckaert, C., Zhu, S., Diamond, S. & Pochet, L., 27 May 2016.

Research output: Contribution to conferenceOther

Estimation of rivaroxaban plasma concentrations in the perioperative setting with or without heparin bridging: an ex vivo study using dedicated chromogenic assays

Lessire, S., Douxfils, J., Pochet, L., Dincq, A-S., Larock, A-S., Gourdin, M., Dogné, J-M., Chatelain, B. & Mullier, F., 13 May 2016, Abstracts of the 62nd Annual Meeting of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis May 25–28, 2016. p. 21 1 p. CA30

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
2015

29ièmes journées Franco-Belges de Pharmacochimie: Meeting report

Frédérick, R., Pochet, L., De Tullio, P. & Dufrasne, F., 17 Nov 2015, In : Pharmaceuticals. 8, 4, p. 758-777 20 p.

Research output: Contribution to journalArticle

Open Access
File
141 Downloads (Pure)

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journalArticle

Open Access

Design of new small molecular weight inhibitors of FXIIa

Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.

Research output: Contribution to conferencePoster

The 2,5-dichlorophenyl fragment as starting point in the design of new FXIIa inhibitors

Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 30 Jun 2015.

Research output: Contribution to conferencePoster

2014

Fragment Expansion of 2,5-Dichlorophenyl to Discover New FXIIa Inhibitors

Bouckaert, C., Serra, S., Frédérick, R. & Pochet, L., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 229

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Pharmacophore And Qsar Models On Coumarins As FXIIa Inhibitors

Bouckaert, C., Meinguet, C., Serra, S. & Pochet, L., 2014.

Research output: Contribution to conferencePoster

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Wouters, J., Pochet, L. & Frédérick, R., 23 Jul 2014, In : European Journal of Medicinal Chemistry. 82, p. 96-105 10 p.

Research output: Contribution to journalArticle

Thiosemicarbazide Derivatives as Novel Indolamine-2,3-dioxygenase (IDO) Inhibitors

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Pochet, L., Wouters, J. & Frédérick, R., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 280

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2013

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
98 Downloads (Pure)

coauthor on lecture: NOVEL DEVELOPMENT IN COUMARINS AS FXIIa INHIBITORS: IMPROVEMENT OF SOLUBILITY

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013, Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. Vol. OC05.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
File
34 Downloads (Pure)

Design and synthesis of thiosemicarbazides as inhibitors of Arginase I, a therapeutic target for anticancer immunotherapy

Colette, C., Vancraeynest, C., Serra, S., Pochet, L. & Frédérick, R., 2013, 2013 Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. p. 45

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis

Pochet, L., Bouckaert, C., Servais, A-C., Farcas, E., Bettonville, V. & Fillet, M., 1 Jan 2013, In : Talanta. 116, p. 719-725 7 p.

Research output: Contribution to journalArticle

Novel coumarins with improved solubility as FXIIa inhibitors

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013.

Research output: Contribution to conferencePoster

Open Access
File
29 Downloads (Pure)
2012

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
59 Downloads (Pure)

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 Jul 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Research output: Contribution to journalArticle

STUDY OF COUMARINS WITH IMPROVED SOLUBILITY TO INHIBIT FXIIa, AN EMERGING TARGET IN THROMBOSIS RESEARCH

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 30 Nov 2012, p. Book of Abstracts, MedChem 2012, Château de Colonster, Liège - November 30, 2012, P01. 1 p.

Research output: Contribution to conferencePoster

File
18 Downloads (Pure)

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

File
240 Downloads (Pure)
2011

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

Pochet, L., Heus, F., Jonker, N., Lingeman, H., Niessen, W. M. A., Kool, J. & Smit, A. B., 15 Jun 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 20, p. 1781-1788 8 p.

Research output: Contribution to journalArticle

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Research output: Contribution to journalArticle