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Research Output 1996 2019

2019
Chromogenics
Plasmas
Heparin
Assays
Low Molecular Weight Heparin

Impact of betrixaban on chromogenic anti-Xa assays - Methodologies improvements

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Bouvy, C., Lessire, S., Mullier, F. & Douxfils, J., 2019, (En attente de publication).

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

File
2018

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access
Anti-Infective Agents
Cytotoxicity
Cells
Peptidoglycan
Structure-Activity Relationship
20 Downloads (Pure)
File
Hemostasis
Viper Venoms
Thrombin Time
Coagulants
Partial Thromboplastin Time
11 Downloads (Pure)
File

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Guldenpfennig, M. & Devroye, C., 18 Jul 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays -Practical laboratory guidance

Siriez, R., Chatelain, B., Devel, P., Dogne, J-M., Douxfils, J., Mullier, F., Pochet, L., Vancraeynest, C., Gheldof, D., Evrard, J., Devroye, C. & Guldenpfennig, M., 10 May 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Betrixaban: Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 5 Jul 2018, JTH - Journal of thrombosis and haemostasis: Research and Practice in thrombosis and haemostasis. Issue S1 ed. Vol. Volume 2. PB364

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban : Impact on routine and specific coagulation assays - A practical laboratory guide

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, BJH - Belgian Journal of Hematology - Clinic: Abstracts - 33rd General Annual Meeting of the Belgian Hematology Society . p. 22 42 p. PP47

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Betrixaban: Impact on routine and specific coagulation assays - Practical laboratory guidance

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Gheldof, D., Chatelain, B., Vancraeynest, C., Devel, P., Guldenpfennig, M., Devroye, C., Mullier, F. & Douxfils, J., 2018, International Society for Laboratory Hematology: Abstracts.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Thromboxane B2
Liquid chromatography
Platelets
Tandem Mass Spectrometry
Liquid Chromatography

Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines

Sennesael, A. L., Panin, N., Vancraeynest, C., Pochet, L., Spinewine, A., Haufroid, V. & Elens, L., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 10514 10514.

Research output: Contribution to journalArticle

HEK293 Cells
Genetic Polymorphisms
Single Nucleotide Polymorphism
Cell Line
Anticoagulants

Enhancing action of positive allosteric modulators through the design of dimeric compounds

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, J. S. & Pirotte, B., 28 Jun 2018, In : Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

Research output: Contribution to journalArticle

Benzothiadiazines
Ligands
Ethane
AMPA Receptors
HEK293 Cells
Nanoreactors
Capillary electrophoresis
Capillary Electrophoresis
Laminar flow
Assays
2017

An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants

Sennesael, A-L., Exner, T., Chatelain, B., Lessire, S., Larock, A-S., Vancraeynest, C., Pochet, L., Dogné, J-M., Spinewine, A., Mullier, F. & Douxfils, J., 1 Sep 2017, In : Thrombosis Research. 157, p. 29-37 9 p.

Research output: Contribution to journalArticle

Prothrombin Time
Anticoagulants
Vitamin K
International Normalized Ratio
Tandem Mass Spectrometry

Capillary electrophoresis in the context of drug discovery

Farcaş, E., Pochet, L., Crommen, J., Servais, A. C. & Fillet, M., 10 Sep 2017, In : Journal of pharmaceutical and biomedical analysis. 144, p. 195-212 18 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
Drug Discovery
Drug Industry
Drug Interactions

Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway

Bouckaert, C., Zhu, S., Govers-Riemslag, J. W. P., Depoorter, M., Diamond, S. L. & Pochet, L., 1 Sep 2017, In : Thrombosis Research. 157, p. 126-133 8 p.

Research output: Contribution to journalArticle

Coumarins
Factor XIIa
Thrombosis
Water
Plasma Kallikrein

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin

Farcas, E., Bouckaert, C., Servais, A. C., Hanson, J., Pochet, L. & Fillet, M., 1 Sep 2017, In : Analytica chimica acta. 984, p. 211-222 12 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
Drug Discovery
Thrombin
electrokinesis
2016

Assessment of Small molecular weight inhibitors of the contact phase

Bouckaert, C., Zhu, S., Diamond, S. & Pochet, L., 27 May 2016.

Research output: Contribution to conferenceOther

Estimation of rivaroxaban plasma concentrations in the perioperative setting with or without heparin bridging: an ex vivo study using dedicated chromogenic assays

Lessire, S., Douxfils, J., Pochet, L., Dincq, A-S., Larock, A-S., Gourdin, M., Dogné, J-M., Chatelain, B. & Mullier, F., 13 May 2016, Abstracts of the 62nd Annual Meeting of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis May 25–28, 2016. p. 21 1 p. CA30

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
Factor XIIa
Coumarins
Structure-Activity Relationship
Enzyme Precursors
Blood Coagulation
2015
62 Downloads (Pure)

29ièmes journées Franco-Belges de Pharmacochimie: Meeting report

Frédérick, R., Pochet, L., De Tullio, P. & Dufrasne, F., 17 Nov 2015, In : Pharmaceuticals. 8, 4, p. 758-777 20 p.

Research output: Contribution to journalArticle

Open Access
File
Open Access
Harmine
Quantitative Structure-Activity Relationship
Solubility
Derivatives
Cells

Design of new small molecular weight inhibitors of FXIIa

Bouckaert, C., Serra, S., Dogne, J-M., Frederick, R. & Pochet, L., 4 Jun 2015.

Research output: Contribution to conferencePoster

2014

Fragment Expansion of 2,5-Dichlorophenyl to Discover New FXIIa Inhibitors

Bouckaert, C., Serra, S., Frédérick, R. & Pochet, L., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 229

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Pharmacophore And Qsar Models On Coumarins As FXIIa Inhibitors

Bouckaert, C., Meinguet, C., Serra, S. & Pochet, L., 2014.

Research output: Contribution to conferencePoster

Indoleamine-Pyrrole 2,3,-Dioxygenase
Derivatives
Scaffolds
Substitution reactions
Immunotherapy

Thiosemicarbazide Derivatives as Novel Indolamine-2,3-dioxygenase (IDO) Inhibitors

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Pochet, L., Wouters, J. & Frédérick, R., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 280

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2013
85 Downloads (Pure)

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Tryptophan Oxygenase
Indoles
Tryptophan
Molecular modeling
Tumors
31 Downloads (Pure)

coauthor on lecture: NOVEL DEVELOPMENT IN COUMARINS AS FXIIa INHIBITORS: IMPROVEMENT OF SOLUBILITY

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013, Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. Vol. OC05.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Open Access
File
Factor XIIa
Coumarins
Solubility
Hemorrhage
Serine Proteases

Design and synthesis of thiosemicarbazides as inhibitors of Arginase I, a therapeutic target for anticancer immunotherapy

Colette, C., Vancraeynest, C., Serra, S., Pochet, L. & Frédérick, R., 2013, 2013 Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. p. 45

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis

Pochet, L., Bouckaert, C., Servais, A-C., Farcas, E., Bettonville, V. & Fillet, M., 1 Jan 2013, In : Talanta. 116, p. 719-725 7 p.

Research output: Contribution to journalArticle

Thrombin
Assays
Chromogenic Compounds
Kinetics
Spectrophotometers
23 Downloads (Pure)
Open Access
File
Coumarins
Factor XIIa
Solubility
Thrombosis
Hemorrhage
2012
53 Downloads (Pure)

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Thiazoles
Bearings (structural)
Bromine
Oxidants
Oxides

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 Jul 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Research output: Contribution to journalArticle

Harmine
Carbolines
Neoplasms
Protein Synthesis Inhibitors
Cytostatic Agents
15 Downloads (Pure)

STUDY OF COUMARINS WITH IMPROVED SOLUBILITY TO INHIBIT FXIIa, AN EMERGING TARGET IN THROMBOSIS RESEARCH

Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 30 Nov 2012, p. Book of Abstracts, MedChem 2012, Château de Colonster, Liège - November 30, 2012, P01. 1 p.

Research output: Contribution to conferencePoster

File
Factor XIIa
Coumarins
Solubility
Thrombosis
Research
229 Downloads (Pure)

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

File
Tryptophan Oxygenase
Immunologic Factors
Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
Heterocyclic Compounds
2011

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

Pochet, L., Heus, F., Jonker, N., Lingeman, H., Niessen, W. M. A., Kool, J. & Smit, A. B., 15 Jun 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 20, p. 1781-1788 8 p.

Research output: Contribution to journalArticle

Acetylcholine
Carrier Proteins
Screening
Ligands
Proteins

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Research output: Contribution to journalArticle

Tryptophan Oxygenase
Indoles
Immunologic Factors
Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
2010

COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke

Kraft, P., Schwarz, T., Stoll, G., Kleinschnitz, C. & Pochet, L., 15 Feb 2010, In : Experimental and Translational Stroke Medicine. 2, 1

Research output: Contribution to journalArticle

Factor XII
Stroke
Middle Cerebral Artery Infarction
Thrombosis
Pharmacology

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Maresca, A., Temperini, C., Pochet, L., Masereel, B., Scozzafava, A. & Supuran, C., 2010, In : Journal of Medicinal Chemistry. 53, p. 335-344 10 p.

Research output: Contribution to journalArticle

Coumarins
Carbonic Anhydrases
Protein Isoforms
Hydroxy Acids
Sulfonamides

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation

Mortier, J., Frederick, R., Pochet, L., Wouters, J., Masereel, B., Ganeff, C., Remouchamps, C., Piette, J., Dejardin, E. & Talaga, P., 15 May 2010, In : Biochemical Pharmacology. 79, 10, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

Isoquinolines
Phosphotransferases
Chemical activation
Enzyme Inhibitors
2009

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M., 2009, In : Pharmacological Research. 59, 3, p. 160-166 7 p.

Research output: Contribution to journalArticle