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Lionel Pochet

  • Belgium

  • 1703 Citations
  • 19 h-Index
19962020
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  • 7 Similar Profiles
Coumarins Medicine & Life Sciences
Factor XIIa Medicine & Life Sciences
Thrombin Medicine & Life Sciences
Capillary electrophoresis Chemical Compounds
Assays Chemical Compounds
Capillary Electrophoresis Medicine & Life Sciences
torsemide Medicine & Life Sciences
Solubility Medicine & Life Sciences

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Projects 2001 2020

Development of new compounds targeting coagulation factor XIIa using innovative microfluidic assays in the context of fragment-based drug discovery

Davoine, C., Pochet, L. & Fillet, M.

1/10/18 → 30/09/20

Project: Research

Design, synthesis and evaluation of FXIIa inhibitors: toward chiral peptidomimetic amidines and guanidines

Simon, F., Lanners, S. & Pochet, L.

1/10/18 → 30/09/20

Project: Research

THROMBO: Enzymologic, mechanistic and pharmacological study of specific inhibitors of serine proteases implicated in hemostasis disorders

Pochet, L., Dogne, J., Masereel, B. & Robert, S.

1/09/04 → …

Project: PHD

Microscale thermophoresis for the analysis of biomolecular interactions

Frédérick, R., Sonveaux, P. & Pochet, L.

1/01/18 → 31/12/19

Project: Research

Prévention de la thrombose sans risque d'hémorragie: mythe ou réalité? Développement d'inhibiteurs sélectifs du FXIIa, une nouvelle cible émergente

Pochet, L.

1/10/12 → 30/09/14

Project: Research

Research Output 1996 2019

Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry

Pochet, L., Dieu, M., Frédérick, R., Murray, A-M., Kempen, I., Pirotte, B. & Masereel, B., 2003, In : Tetrahedron. 59, p. 4557-4561 5 p.

Research output: Contribution to journal › Article

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

Pochet, L., Heus, F., Jonker, N., Lingeman, H., Niessen, W. M. A., Kool, J. & Smit, A. B., 15 Jun 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 20, p. 1781-1788 8 p.

Research output: Contribution to journal › Article

Acetylcholine
Carrier Proteins
Screening
Ligands
Proteins

Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

Robert, S., Bertolla, C., Masereel, B., Dogné, J-M. & Pochet, L., 2008, In : Journal of Medicinal Chemistry. 51, p. 3077-3081 5 p.

Research output: Contribution to journal › Article

Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Bouvy, C., Lessire, S., Mullier, F. & Douxfils, J., 1 Apr 2019, In : International Journal of Laboratory Hematology. 41, 2, p. 250-261 12 p.

Research output: Contribution to journal › Article

Chromogenics
Plasmas
Heparin
Assays
Low Molecular Weight Heparin

Impact of betrixaban on chromogenic anti-Xa assays: Methodologies improvements

Siriez, R., Evrard, J., Dogne, J-M., Pochet, L., Bouvy, C., Lessire, S., Mullier, F. & Douxfils, J., 2019.

Research output: Contribution to conference › Poster

File

Thesis

Conception, synthèse et évaluation biologique de 2-thiohydantoïnes en tant qu'inhibiteurs potentiels des cyclooxygénases

Author: Gauthier, M., 17 Dec 2004

Supervisor: Masereel, B. (Supervisor), Flamion, B. (Jury), Pochet, L. (Jury), Vincent, S. (Jury), Wouters, J. (Jury), GUEIFFIER, A. (External person) (Jury) & Lambert, D. M. (External person) (Jury)

Student thesis: Doc types › Doctor of Sciences

Conception, synthèse et évaluation biologique de coumarines en tant qu'inhibiteurs de protéases à sérine

Author: Pochet, L., 2000

Supervisor: Masereel, B. (Supervisor)

Student thesis: Doc types › Doctor of Sciences

Design, synthesis and evaluation of coagulation FXIIa inhibitors as potential antithrombotic agents

Author: Bouckaert, C., 16 May 2017

Supervisor: Pochet, L. (Supervisor), Dogne, J. (Co-Supervisor), Lanners, S. (President), De Tullio, P. (External person) (Jury), Chatelain, C. (External person) (Jury) & TEN CATE, H. (External person) (Jury)

Student thesis: Doc types › Doctor of Biomedical and Pharmaceutical Sciences

Development & validation of pharmacological tools for the preclinical testing of anticoagulants

Author: Robert, S., 7 Apr 2011

Supervisor: Pochet, L. (Supervisor), Dogne, J. (Co-Supervisor), Masereel, B. (President), Caron, N. (Jury), Chatelain, C. (External person) (Jury) & TEN CATE, H. (External person) (Jury)

Student thesis: Doc types › Doctor of Biomedical and Pharmaceutical Sciences

Etude de l'inhibition de l'alpha-chymotrypsine par les dérivés de la coumarine

Author: Cuisenaire, J., 2000

Supervisor: Pochet, L. (Co-Supervisor) & Masereel, B. (Supervisor)

Student thesis: Master types › Master in Biomedicine

Press / Media

AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER

Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet

2/02/12

1 item of Media coverage

Press/Media: Research

AVANCÉE SIGNIFICATIVE DANS LE TRAITEMENT DU CANCER

Eduard Dolusic, Raphaël Frederick, Bernard Masereel, Johan Wouters, Laurence Moineaux & Lionel Pochet

2/02/12

1 item of Media coverage

Press/Media: Research