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Research Output

2012
Open Access
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Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J-M., Masereel, B., Frédérick, R. & Wouters, J., 1 Aug 2012, In : European Journal of Medicinal Chemistry. 54, p. 95-102 8 p.

Research output: Contribution to journalArticle

Open Access
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139 Downloads (Pure)

Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18

Flagothier, J., Kaisin, G., Mercier, F., Thonon, D., Teller, N., Wouters, J. & Luxen, A., 1 Aug 2012, In : Applied Radiation and Isotopes. 70, 8, p. 1549-1557 9 p.

Research output: Contribution to journalArticle

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

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236 Downloads (Pure)

Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity

Vergote, T., Nahra, F., Welle, A., Mager, N., Riant, O., Leyssens, T., Luhmer, M. & Wouters, J., 16 Jan 2012, In : Chemistry: A European Journal. 18, 3, p. 793-798 6 p.

Research output: Contribution to journalArticle

Zavalíaite, (Mn,Fe,Mg)(PO ), a new member of the sarcopside group from the La Empleada pegmatite, San Luis Province, Argentina

Hatert, F., Roda-Robles, E., De Parseval, P. & Wouters, J., 1 Dec 2012, In : Canadian Mineralogist. 50, 6, p. 1445-1452 8 p.

Research output: Contribution to journalArticle

2013

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
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97 Downloads (Pure)

Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Verbrugghen, T., Van Calenbergh, S., Vandurm, P., Pouyez, J., Wouters, J. & Maes, L., 10 Jan 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 376-380 5 p.

Research output: Contribution to journalArticle

Direct access to 1-aryl-5-amino-1,2,4-triazoles and [1,2,4]triazolo[1,5-a] pyridines by two new single-step reactions from 1,3,4-thiadiazol-2-amines

Mammoliti, O., Quinton, E. M., Loones, K. T. J., Nguyen, A. T., Wouters, J. & Van Lommen, G., 4 Feb 2013, In : Tetrahedron. 69, 5, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 Jan 2013, In : Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

3 Downloads (Pure)

"Magic" surface clustering of borazines driven by repulsive intermolecular forces

Kervyn De Meerendre, S., Kalashnyk, N., Riello, M., Moreton, B., Tasseroul, J., Wouters, J., Jones, T. S., De Vita, A., Costantini, G. & Bonifazi, D., 15 Jul 2013, In : Angewandte Chemie. International edition. 52, 29, p. 7410-7414 5 p.

Research output: Contribution to journalArticle

Mechanistic insight into the Staudinger reaction catalyzed by N-heterocyclic carbenes

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 15 Jul 2013, In : Chemistry: A European Journal. 19, 29, p. 9668-9676 9 p.

Research output: Contribution to journalArticle

Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

Wouters, J., Grepioni, F., Braga, D., Kaminski, R. M., Rome, S., Aerts, L. & Quéré, L., 28 Nov 2013, In : CrystEngComm. 15, 44, p. 8898-8902 5 p.

Research output: Contribution to journalArticle

On the influence of using a zwitterionic coformer for cocrystallization: Structural focus on naproxen-proline cocrystals

Tilborg, A., Norberg, B., Wouters, J., Springuel, G. & Leyssens, T., 7 May 2013, In : CrystEngComm. 15, 17, p. 3341-3350 10 p.

Research output: Contribution to journalArticle

Polymorphism, fluorescence, and optoelectronic properties of a borazine derivative

Kervyn De Meerendre, S., Fenwick, O., Di Stasio, F., Shin, Y. S., Wouters, J., Accorsi, G., Osella, S., Beljonne, D., Cacialli, F. & Bonifazi, D., 10 Jun 2013, In : Chemistry: A European Journal. 19, 24, p. 7771-7779 9 p.

Research output: Contribution to journalArticle

Solid-state-trapped reactive ammonium carbamate self-derivative salts of prolinamide

Tilborg, A., Lanners, S., Norberg, B. & Wouters, J., 1 Dec 2013, In : ChemistryOPEN. 2, 5-6, p. 194-199 6 p.

Research output: Contribution to journalArticle

2014

2,5-Diamide-substituted five-membered heterocycles: Challenging molecular synthons

Fabbro, C., Armani, S., Carloni, L. E., De Leo, F., Wouters, J. & Bonifazi, D., 2014, In : European Journal of Organic Chemistry. 2014, 25, p. 5487–5500 14 p.

Research output: Contribution to journalArticle

Bis-(1,2,3,4-tetrahydroisoquinolinium): A Chiral Scaffold for Developing High-Affinity Ligands for SK Channels

Liégeois, J. F., Wouters, J., Seutin, V. & Dilly, S., Apr 2014, In : ChemMedChem.

Research output: Contribution to journalArticle

Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration

Badarau, E., Dilly, S., Wouters, J., Seutin, V. & Liégeois, J. F., 15 Dec 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 24, p. 5616-5620 5 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)

Cocrystal formation between chiral compounds: How cocrystals differ from salts

Springuel, G., Robeyns, K., Norberg, B., Wouters, J. & Leyssens, T., 6 Aug 2014, In : Crystal Growth and Design. 14, 8, p. 3996-4004 9 p.

Research output: Contribution to journalArticle

Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: Dimethylallyl diphosphate isomerase from streptococcus pneumoniae

De Ruyck, J., Janczak, M. W., Neti, S. S., Rothman, S. C., Schubert, H. L., Cornish, R. M., Matagne, A., Wouters, J. & Poulter, C. D., 7 Jul 2014, In : ChemBioChem. 15, 10, p. 1452-8 7 p.

Research output: Contribution to journalArticle

Does chirality influence the tendency toward cocrystal formation?

George, F., Tumanov, N., Norberg, B., Robeyns, K., Filinchuk, Y., Wouters, J. & Leyssens, T., 4 Jun 2014, In : Crystal Growth and Design. 14, 6, p. 2880-2892 13 p.

Research output: Contribution to journalArticle

How cocrystallization affects solid-state tautomerism : Stanozolol case study

Tilborg, A., Springuel, G., Norberg, B., Wouters, J. & Leyssens, T., 2 Jul 2014, In : Crystal Growth and Design. 14, 7, p. 3408-3422 15 p.

Research output: Contribution to journalArticle

Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Grepioni, F., Wouters, J., Braga, D., Nanna, S., Fours, B., Coquerel, G., Longfils, G., Rome, S., Aerts, L. & Quéré, L., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5887-5896 10 p.

Research output: Contribution to journalArticle

Mechanosynthesis, a method of choice in solid state synthesis

Dubois, J., Colaco, M. O. & Wouters, J., Dec 2014, In : Chimie nouvelle. 117, p. 21-30 10 p.

Research output: Contribution to journalArticle

52 Downloads (Pure)

Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular lamination: Regioselective synthesis of N 1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase

Takagi, K., Al-Amin, M., Hoshiya, N., Wouters, J., Sugimoto, H., Shiro, Y., Fukuda, H., Shuto, S. & Arisawa, M., 3 Jul 2014, In : Journal of Organic Chemistry. 79, 13, p. 6366-6371 6 p.

Research output: Contribution to journalArticle

Open Access
30 Downloads (Pure)

Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J. & Liégeois, J. F., 25 Sep 2014, In : Journal of molecular structure. 1074, p. 435-440 6 p.

Research output: Contribution to journalArticle

Structural insight into cocrystallization with zwitterionic co-formers: Cocrystals of S-naproxen

Tumanova, N., Tumanov, N., Robeyns, K., Filinchuk, Y., Wouters, J. & Leyssens, T., 21 Sep 2014, In : CrystEngComm. 16, 35, p. 8185-8196 12 p.

Research output: Contribution to journalArticle

Synthesis of ferrocene-labelled 2-aminopyrimidine derivatives via homogeneous catalytic carbonylation

Fehér, C., Habuš, I., Wouters, J. & Skoda-Földes, R., 4 Sep 2014, In : Monatshefte fur Chemie. 145, 12, p. 1981-1986 6 p.

Research output: Contribution to journalArticle

23 Downloads (Pure)

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro

Chofor, R., Risseeuw, M. D. P., Pouyez, J., Johny, C., Wouters, J., Dowd, C. S., Couch, R. D. & Van Calenbergh, S., 1 Feb 2014, In : Molecules. 19, 2, p. 2571-2587 17 p.

Research output: Contribution to journalArticle

Open Access

Thiosemicarbazide Derivatives as Novel Indolamine-2,3-dioxygenase (IDO) Inhibitors

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Pochet, L., Wouters, J. & Frédérick, R., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 280

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journalArticle

Open Access

A biomimetic heteroditopic receptor for zwitterions in protic media

Cornut, D., Moerkerke, S., Wouters, J., Bruylants, G. & Jabin, I., 2015, In : Chemistry - An Asian Journal. 10, 2, p. 440-446 7 p.

Research output: Contribution to journalArticle

Concentré de CHIMIE

Wouters, J., 2015, Presses universitaires de Namur. 404 p.

Research output: Book/Report/JournalBook

4 Downloads (Pure)

Mechanochemical synthesis of phthalimides with crystal structures of intermediates and products

Colaco, M. O., Dubois, J. & Wouters, J., 28 Mar 2015, In : CrystEngComm. 17, 12, p. 2523-2528 6 p.

Research output: Contribution to journalArticle

Probing the Diastereoselectivity of Staudinger Reactions Catalyzed by N-Heterocyclic Carbenes

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 1 Jul 2015, In : Chemistry: A European Journal. 21, 30, p. 10870-10877 8 p.

Research output: Contribution to journalArticle

Selective Recognition of Phosphatidylcholine Lipids by a Biomimetic Calix[6]tube Receptor

Moerkerke, S., Wouters, J. & Jabin, I., 10 Aug 2015, In : Journal of Organic Chemistry. 80, 17, p. 8720-8726 7 p.

Research output: Contribution to journalArticle

Solid-state investigation on a new dimorphic substituted N-salicylidene compound: Insights into its thermochromic behaviour

Carletta, A., Dubois, J., Tilborg, A. & Wouters, J., 14 May 2015, In : CrystEngComm. 17, 18, p. 3509-3518 10 p.

Research output: Contribution to journalArticle

20 Downloads (Pure)

Stereoselective synthesis of boat-locked glycosides designed as glycosyl hydrolase conformational probes

Thiery, E., Reniers, J., Wouters, J. & Vincent, S. P., 2015, In : European Journal of Organic Chemistry. 2015, 7, p. 1472-1484 13 p.

Research output: Contribution to journalArticle

2 Downloads (Pure)

Structural Investigation of Substituent Effect on Hydrogen Bonding in (S)-Phenylglycine Amide Benzaldimines

George, F., Norberg, B., Wouters, J. & Leyssens, T., 5 Aug 2015, In : Crystal Growth and Design. 15, 8, p. 4005-4019 15 p.

Research output: Contribution to journalArticle

Supramolecular Assistance for the Selective Demethylation of Calixarene-Based Receptors

Danjou, P. E., De Leener, G., Cornut, D., Moerkerke, S., Mameri, S., Lascaux, A., Wouters, J., Brugnara, A., Colasson, B., Reinaud, O. & Jabin, I., 15 May 2015, In : Journal of Organic Chemistry. 80, 10, p. 5084-5091 8 p.

Research output: Contribution to journalArticle