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Research Output 1992 2020

2006

Indanesulfonamides as carbonic anhydrase inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Dogné, J-M., Wouters, J., Supuran, C. T. & Masereel, B., 2006, In : Drugs of the future. 31, A

Research output: Contribution to journalLiterature review

Carbonic Anhydrase Inhibitors
Isoenzymes
Tumors
Carbonic Anhydrases
Neoplasms

Short, asymmetric synthesis of epi-morphine ACNO analogues

Heureux, N., Wouters, J., Norberg, B. & Markó, I. E., 25 Oct 2006, In : Organic and Biomolecular Chemistry. 4, 21, p. 3898-3900 3 p.

Research output: Contribution to journalArticle

morphine
Imines
Ketones
Morphine
Opioid Analgesics

Structural insights into human 5-lipoxygenase inhibition: Combined ligand-based and target-based approach

Charlier, C., Hénichart, J. P., Durant, F. & Wouters, J., 12 Jan 2006, In : Journal of Medicinal Chemistry. 49, 1, p. 186-195 10 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Hydrogen
Hydrogen bonds
Ligands
Oxidation-Reduction
Isomerases
Mutagenesis
Crystallography
Site-Directed Mutagenesis
Escherichia coli

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

Muccioli, G. G., Fazio, N., Scriba, G. K. E., Poppitz, W., Cannata, F., Poupaert, J. H., Wouters, J. & Lambert, D. M., 12 Jan 2006, In : Journal of Medicinal Chemistry. 49, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

Hydantoins
Cannabinoid Receptor CB1
Derivatives
Cannabinoid Receptor CB2
Ligands

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

Frédérick, R., Dumont, W., Ooms, F., Aschenbach, L., Van Der Schyf, C. J., Castagnoli, N., Wouters, J. & Krief, A., 15 Jun 2006, In : Journal of Medicinal Chemistry. 49, 12, p. 3743-3747 5 p.

Research output: Contribution to journalArticle

Monoamine Oxidase Inhibitors
Monoamine Oxidase
Enzyme Inhibitors
pyridazine

Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB 1 cannabinoid receptor inverse agonists/antagonists

Muccioli, G. G., Wouters, J., Charlier, C., Scriba, G. K. E., Pizza, T., Di Pace, P., De Martino, P., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 9 Feb 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 872-882 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Cannabinoid Receptor CB1
Cannabinoid Receptors
Derivatives
Opiate Alkaloids
2005

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B

Frédérick, R., Ooms, F., Castagnoli, N., Petzer, J. P., Feng, J. F., Schwarzschild, M. A., Van Der Schyf, C. J. & Wouters, J., 1 Sep 2005, In : Acta crystallographica Section C: Crystal Structure communications. 61, 9

Research output: Contribution to journalArticle

Adenosine A2 Receptor Antagonists
caffeine
adenosines
Xanthine
Monoamine Oxidase

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: New templates among the CB1 cannabinoid receptor inverse agonists

Muccioli, G. G., Wouters, J., Scriba, G. K. E., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 17 Nov 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7486-7490 5 p.

Research output: Contribution to journalArticle

Phenylthiourea
Cannabinoid Receptor Agonists
Cannabinoid Receptor CB1
Phenylurea Compounds
Cannabinoid Receptor CB2
Factor Xa
Thrombin
hydrazine
Coumarins
Chymotrypsin

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase

Wouters, J., Yin, F., Song, Y., Zhang, Y., Oudjama, Y., Stalon, V., Droogmans, L., Morita, C. & Oldfield, E., 2005, In : Journal of the American Chemical Society. 127, p. 536-537 2 p.

Research output: Contribution to journalArticle

meropenem
Enterobacter cloacae
Stereoselectivity
Crystal structure
Catalytic Domain

Cyproterone and a comparison with its acetate ester

De Ruyck, J., De Hassonville, S. H., Liégeois, J. F. & Wouters, J., 1 Nov 2005, In : Acta Crystallographica Section E. 61, 11

Research output: Contribution to journalArticle

Cyproterone
Conformations
esters
acetates
Esters

Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials

Salvagnini, C., Michaux, C., Remiche, J., Wouters, J., Charlier, P. & Marchand-Brynaert, J., 7 Dec 2005, In : Organic and Biomolecular Chemistry. 3, 23, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

thrombin
Thrombin
inhibitors
blood
Polymers

Developpement d'indanesulfonamides inhibiteurs de l'anhydrase carbonique IX

Thiry, A., Ledecq, M., Chazalette, C., Wouters, J., SUPURAN, C. T. & Masereel, B., 2005, Abstract Book-19èmes Journées Franco-Belge de pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Molecular recognition
Calorimetry
Biological Science Disciplines
Drug Design
Differential Scanning Calorimetry

Head-on immobilization of DNA fragments on CVD-diamond layers

Wenmackers, S., Christiaens, P., Deferme, W., Daenen, M., Haenen, K., Nesládek, M., Wagner, P., Vermeeren, V., Michiels, L., VandeVen, M., Ameloot, M., Wouters, J., Naelaerts, L. & Mekhalif, Z., 1 Dec 2005, Materials Science Forum. Vol. 492-493. p. 267-272 6 p. (Materials Science Forum; vol. 492-493).

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Diamond
Chemical vapor deposition
Diamonds
DNA
Assays

Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate

Wu, Z., Wouters, J. & Poulter, C. D., 14 Dec 2005, In : Journal of the American Chemical Society. 127, 49, p. 17433-17438 6 p.

Research output: Contribution to journalArticle

Isomerases
Protonation
Deprotonation
Stereochemistry
Carbon

Overexpression, purification, crystallization and crystallographic analysis of CopK of Cupriavidus metallidurans

Tricot, C., Van Aelst, S., Wattiez, R., Mergeay, M., Stalon, V. & Wouters, J., 1 Sep 2005, In : Acta Crystallographica Section F. 61, 9, p. 825-827 3 p.

Research output: Contribution to journalArticle

Cupriavidus
Crystallization
purification
Purification
amino acids

Sequential acid/base-catalyzed polycyclization of tryptamine derivatives. A rapid access to Büchi's ketone

Heureux, N., Wouters, J. & Markó, I. E., 10 Nov 2005, In : Organic Letters. 7, 23, p. 5245-5248 4 p.

Research output: Contribution to journalArticle

Aspidosperma
Strychnos
tryptamines
decarboxylation
Decarboxylation
isopentenyldiphosphate delta-isomerase
Thermus thermophilus
Flavin Mononucleotide
Isomerases
Crystallography

Substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one as CB 1 cannabinoid receptor ligands: Synthesis and pharmacological evaluation

Muccioli, G. G., Martin, D., Scriba, G. K. E., Poppitz, W., Poupaert, J. H., Wouters, J. & Lambert, D. M., 7 Apr 2005, In : Journal of Medicinal Chemistry. 48, 7, p. 2509-2517 9 p.

Research output: Contribution to journalArticle

Thiohydantoins
Cannabinoid Receptors
Hydantoins
Pharmacology
Ligands
2004

A primordial RNA modification enzyme: The case of tRNA (m1A) methyltransferase

Roovers, M., Wouters, J., Bujnicki, J. M., Tricot, C., Stalon, V., Grosjean, H. & Droogmans, L., 10 Mar 2004, In : Nucleic Acids Research. 32, 2, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access
tRNA Methyltransferases
Transfer RNA
RNA
Archaea
Enzymes

Crystal Structure of the C67A Mutant of Isopentenyl Diphosphate Isomerase Complexed with a Mechanism-Based Irreversible Inhibitor

Wouters, J., Oudjama, Y., Stalon, V., Droogmans, L. & Poulter, C. D., 1 Feb 2004, In : Proteins: Structure, Function and Genetics. 54, 2, p. 216-221 6 p.

Research output: Contribution to journalArticle

Isomerases
Protonation
Isomerization
Carbon
Crystal structure
Monoamine Oxidase
Crystal structure
Biochemistry
Sequence Analysis
Proteins

Modeling of human monoamine oxidase A : from low resolution threading models to accurate comparative models based on crystal structures

Leonard, N., Lambert, C., Depiereux, E. & Wouters, J., 2004, Monoamine oxidases: molecular, pharmacological and neurotoxicological aspects: a tribute to professor Merton Sandler. Nicotra, A., Parvez, S. H., Glover, V., Sler, M., Parvez, S. & Minami, M. (eds.). Amsterdam: Elsevier, p. 47-61 15 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Monoamine Oxidase Inhibitors
oxidase
Monoamine Oxidase
inhibitors
Hydrogen
2003
Thromboxane Receptors
Thromboxanes
Urea
Hydrogen
Pharmacology

A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins

Muccioli, G. G., Poupaert, J. H., Wouters, J., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 17 Feb 2003, In : Tetrahedron. 59, 8, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

Thiohydantoins
Hydantoins
Phenytoin
Microwaves
Chemical activation

Biologie in silico: point de vue de bioinformaticiens

Lambert, C., Wouters, J., De Bolle, X. & Depiereux, E., 2003, In : Chimie nouvelle. 83, p. 106-111 6 p.

Research output: Contribution to journalArticle

Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors

Wouters, J., Oudjama, Y., Barkley, S. J., Tricot, C., Stalon, V., Droogmans, L. & Poulter, C. D., 4 Apr 2003, In : Journal of Biological Chemistry. 278, 14, p. 11903-11908 6 p.

Research output: Contribution to journalArticle

Open Access
Isomerases
Diphosphates
Terpenes
Escherichia coli
Crystal structure

Crystal structure of Enterobacter cloacae 908R class C β-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue

Wouters, J., Fonzé, E., Vermeire, M., Frère, J. M. & Charlier, P., 1 Aug 2003, In : Cellular and Molecular Life Sciences. 60, 8, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Boronic Acids
Enterobacter cloacae
Catalytic Domain
X Ray Crystallography
Hydrolases

Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative

Ooms, F., Frédérick, R., Durant, F., Petzer, J. P., Castagnoli, N., Van der Schyf, C. J. & Wouters, J., 6 Jan 2003, In : Bioorganic & Medicinal Chemistry Letters. 13, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Derivatives
Monoamine Oxidase Inhibitors
Hydrophobic and Hydrophilic Interactions

Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A

Massant, J., Wouters, J. & Glansdorff, N., 1 Dec 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 12, p. 2140-2149 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrococcus furiosus
Ornithine Carbamoyltransferase
Extreme Heat
Carbamyl Phosphate
Ions

Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins

Muccioli, G. G., Wouters, J., Poupaert, J. H., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 2 Oct 2003, In : Organic Letters. 5, 20, p. 3599-3602 4 p.

Research output: Contribution to journalArticle

Phenylurea Compounds
Thiohydantoins
Phenylthiourea
Hydantoins
Microwaves

Wavpred: a wavelet-based algorithm for the prediction of transmembrane proteins

Fischer, P., Baudoux, G. & Wouters, J., 2003, In : Comm. math. sci.. 1, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Yeast epiarginase regulation, an enzyme-enzyme activity control. Identification of residues of ornithine carbamoyltransferase and arginase responsible for enzyme catalytic and regulatory activities

El Alami, M., Dubois, E., Oudjama, Y., Tricot, C., Wouters, J., Stalon, V. & Messenguy, F., 13 Jun 2003, In : Journal of Biological Chemistry. 278, 24, p. 21550-21558 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ornithine Carbamoyltransferase
Arginase
Ornithine
Enzyme activity
Yeast

Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling

Geha, R. M., Chen, K., Wouters, J. & Shih, J. C., 10 May 2002, In : Journal of Biological Chemistry. 277, 19, p. 17209-17216 8 p.

Research output: Contribution to journalArticle

Molecular modeling
Monoamine Oxidase
Catalytic Domain
Amino Acids
Catalyst activity

Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB1 cannabinoid receptor ligands and potential antagonists: Synthesis, lipophilicity, affinity, and molecular modeling

Ooms, F., Wouters, J., Oscari, O., Happaerts, T., Bouchard, G., Carrupt, P. A., Testa, B. & Lambert, D. M., 25 Apr 2002, In : Journal of Medicinal Chemistry. 45, 9, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

Hydantoins
Cannabinoid Receptor CB1
Molecular modeling
Cannabinoids
Ligands

Polymorphism of N-stearoylethanolamine: Differential scanning calorimetric, vibrational spectroscopic (FTIR), and crystallographic studies

Wouters, J., Vandevoorde, S., Culot, C., Docquir, F. & Lambert, D. M., 1 Oct 2002, In : Chemistry and Physics of Lipids. 119, 1-2, p. 13-21 9 p.

Research output: Contribution to journalArticle

Fourier Transform Infrared Spectroscopy
Polymorphism
Powders
Scanning
Molecules

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Wouters, J., Huygens, M., Pochet, L., Pirotte, B., Durant, F. & Masereel, B., 8 Apr 2002, In : Bioorganic and medicinal chemistry letters. 12, 7, p. 1109-1112 4 p.

Research output: Contribution to journalArticle

Coumarins
Chymotrypsin

The endoxylanases from family 11: Computer analysis of protein sequences reveals important structural and phylogenetic relationships

Sapag, A., Wouters, J., Lambert, C., De Ioannes, P., Eyzaguirre, J. & Depiereux, E., 9 Mar 2002, In : Journal of Biotechnology. 95, 2, p. 109-131 23 p.

Research output: Contribution to journalArticle

Endo-1,4-beta Xylanases
Protein Sequence Analysis
Enzymes
Glutamates
Proteins
2001

Crystallographic analysis of family 11 endo-β-l,4-xylanase Xyl1 from Streptomyces sp. S38

Wouters, J., Georis, J., Engher, D., Vandenhaute, J., Dusart, J., Frere, J. M., Depiereux, E. & Charlier, P., 31 Dec 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 12, p. 1813-1819 7 p.

Research output: Contribution to journalArticle

Xylans
Streptomyces
xyl1 xylanase
hemicellulose
torsemide
Prostaglandin H2 Receptors Thromboxane A2
Thromboxane A2
Thromboxanes
Inhibitory Concentration 50
Enterobacter cloacae
Glycols
X ray analysis
Crystallization
purification

La banque de données structurales de Cambridge, un trésor d'informations

Van Meervelt, L. & Wouters, J., 2001, In : Chimie nouvelle. 73, p. 3230-3233 4 p.

Research output: Contribution to journalArticle

Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists

Dogné, J-M., de Leval, X., Neven, P., Somers, F., Delarge, J., Rolin, S., Michaux, C., Wouters, J., Pirotte, B., Damas, J. & Masereel, B., 2001, In : Fundamental and Clinical Pharmacology. 300

Research output: Contribution to journalLiterature review