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Research Output

2006

Design, synthesis and biological evaluation of indanesulfonamides as carbonic anhydrase IX inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Dogné, J-M., Wouters, J., Supuran, C. T. & Masereel, B., 2006, In : Fundamental and Clinical Pharmacology. 20

Research output: Contribution to journalLiterature review

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Determination of physical changes of inulin related to sorption isotherms: An X-ray diffraction, modulated differential scanning calorimetry and environmental scanning electron microscopy study

Ronkart, S., Blecker, C., Fougnies, C., Van Herck, J. C., Wouters, J. & Paquot, M., 3 Feb 2006, In : Carbohydrate Polymers. 63, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

Identification, cloning, and expression of the Scytalidium acidophilum XYL1 gene encoding for an acidophilic xylanase

Al Balaa, B., Wouters, J., Dogne, S., Rossini, C., Schaus, J. M., Depiereux, E., Vandenhaute, J. & Housen, I., 2 Feb 2006, In : Bioscience, biotechnology and biochemistry. 70, 1, p. 269-272 4 p.

Research output: Contribution to journalArticle

Indanesulfonamides as carbonic anhydrase inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Dogné, J-M., Wouters, J., Supuran, C. T. & Masereel, B., 2006, In : Drugs of the future. 31, A

Research output: Contribution to journalLiterature review

Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX

Thiry, A., Ledecq, M., Cecchi, A., Dogne, J-M., Wouters, J., Supuran, C. T. & Masereel, B., 4 May 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2743-2749 7 p.

Research output: Contribution to journalArticle

Short, asymmetric synthesis of epi-morphine ACNO analogues

Heureux, N., Wouters, J., Norberg, B. & Markó, I. E., 25 Oct 2006, In : Organic and Biomolecular Chemistry. 4, 21, p. 3898-3900 3 p.

Research output: Contribution to journalArticle

Structural insights into human 5-lipoxygenase inhibition: Combined ligand-based and target-based approach

Charlier, C., Hénichart, J. P., Durant, F. & Wouters, J., 12 Jan 2006, In : Journal of Medicinal Chemistry. 49, 1, p. 186-195 10 p.

Research output: Contribution to journalArticle

Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: Site-directed mutagenesis, enzymology, and protein crystallography

De Ruyck, J., Durisotti, V., Oudjama, Y. & Wouters, J., 30 Jun 2006, In : Journal of Biological Chemistry. 281, 26, p. 17864-17869 6 p.

Research output: Contribution to journalArticle

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

Muccioli, G. G., Fazio, N., Scriba, G. K. E., Poppitz, W., Cannata, F., Poupaert, J. H., Wouters, J. & Lambert, D. M., 12 Jan 2006, In : Journal of Medicinal Chemistry. 49, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

Frédérick, R., Dumont, W., Ooms, F., Aschenbach, L., Van Der Schyf, C. J., Castagnoli, N., Wouters, J. & Krief, A., 15 Jun 2006, In : Journal of Medicinal Chemistry. 49, 12, p. 3743-3747 5 p.

Research output: Contribution to journalArticle

Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB 1 cannabinoid receptor inverse agonists/antagonists

Muccioli, G. G., Wouters, J., Charlier, C., Scriba, G. K. E., Pizza, T., Di Pace, P., De Martino, P., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 9 Feb 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 872-882 11 p.

Research output: Contribution to journalArticle

2005

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B

Frédérick, R., Ooms, F., Castagnoli, N., Petzer, J. P., Feng, J. F., Schwarzschild, M. A., Van Der Schyf, C. J. & Wouters, J., 1 Sep 2005, In : Acta crystallographica Section C: Crystal Structure communications. 61, 9

Research output: Contribution to journalArticle

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: New templates among the CB1 cannabinoid receptor inverse agonists

Muccioli, G. G., Wouters, J., Scriba, G. K. E., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 17 Nov 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7486-7490 5 p.

Research output: Contribution to journalArticle

3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Frédérick, R., Robert, S., Masereel, B., Pochet, L., Pirotte, B., Charlier, C., De Ruyck, J. & Wouters, J., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7592-7603 12 p.

Research output: Contribution to journalArticle

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase

Wouters, J., Yin, F., Song, Y., Zhang, Y., Oudjama, Y., Stalon, V., Droogmans, L., Morita, C. & Oldfield, E., 2005, In : Journal of the American Chemical Society. 127, p. 536-537 2 p.

Research output: Contribution to journalArticle

Cyproterone and a comparison with its acetate ester

De Ruyck, J., De Hassonville, S. H., Liégeois, J. F. & Wouters, J., 1 Nov 2005, In : Acta Crystallographica Section E. 61, 11

Research output: Contribution to journalArticle

Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials

Salvagnini, C., Michaux, C., Remiche, J., Wouters, J., Charlier, P. & Marchand-Brynaert, J., 7 Dec 2005, In : Organic and Biomolecular Chemistry. 3, 23, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

Developpement d'indanesulfonamides inhibiteurs de l'anhydrase carbonique IX

Thiry, A., Ledecq, M., Chazalette, C., Wouters, J., SUPURAN, C. T. & Masereel, B., 2005, Abstract Book-19èmes Journées Franco-Belge de pharmacochimie.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Head-on immobilization of DNA fragments on CVD-diamond layers

Wenmackers, S., Christiaens, P., Deferme, W., Daenen, M., Haenen, K., Nesládek, M., Wagner, P., Vermeeren, V., Michiels, L., VandeVen, M., Ameloot, M., Wouters, J., Naelaerts, L. & Mekhalif, Z., 1 Dec 2005, Materials Science Forum. Vol. 492-493. p. 267-272 6 p. (Materials Science Forum; vol. 492-493).

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate

Wu, Z., Wouters, J. & Poulter, C. D., 14 Dec 2005, In : Journal of the American Chemical Society. 127, 49, p. 17433-17438 6 p.

Research output: Contribution to journalArticle

Overexpression, purification, crystallization and crystallographic analysis of CopK of Cupriavidus metallidurans

Tricot, C., Van Aelst, S., Wattiez, R., Mergeay, M., Stalon, V. & Wouters, J., 1 Sep 2005, In : Acta Crystallographica Section F. 61, 9, p. 825-827 3 p.

Research output: Contribution to journalArticle

Sequential acid/base-catalyzed polycyclization of tryptamine derivatives. A rapid access to Büchi's ketone

Heureux, N., Wouters, J. & Markó, I. E., 10 Nov 2005, In : Organic Letters. 7, 23, p. 5245-5248 4 p.

Research output: Contribution to journalArticle

Structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase inferred from crystallography and molecular dynamics

De Ruyck, J., Rothman, S. C., Poulter, C. D. & Wouters, J., 23 Dec 2005, In : Biochemical and Biophysical Research Communications. 338, 3, p. 1515-1518 4 p.

Research output: Contribution to journalArticle

Substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one as CB 1 cannabinoid receptor ligands: Synthesis and pharmacological evaluation

Muccioli, G. G., Martin, D., Scriba, G. K. E., Poppitz, W., Poupaert, J. H., Wouters, J. & Lambert, D. M., 7 Apr 2005, In : Journal of Medicinal Chemistry. 48, 7, p. 2509-2517 9 p.

Research output: Contribution to journalArticle

2004

A primordial RNA modification enzyme: The case of tRNA (m1A) methyltransferase

Roovers, M., Wouters, J., Bujnicki, J. M., Tricot, C., Stalon, V., Grosjean, H. & Droogmans, L., 10 Mar 2004, In : Nucleic Acids Research. 32, 2, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access

Crystal Structure of the C67A Mutant of Isopentenyl Diphosphate Isomerase Complexed with a Mechanism-Based Irreversible Inhibitor

Wouters, J., Oudjama, Y., Stalon, V., Droogmans, L. & Poulter, C. D., 1 Feb 2004, In : Proteins: Structure, Function and Genetics. 54, 2, p. 216-221 6 p.

Research output: Contribution to journalArticle

Modeling of Human Monoamine Oxidase A: From Low Resolution Threading Models to Accurate Comparative Models Based on Crystal Structures

Léonard, N., Lambert, C., Depiereux, E. & Wouters, J., 1 Jan 2004, In : Neurotoxicology. 25, 1-2, p. 47-61 15 p.

Research output: Contribution to journalArticle

Modeling of human monoamine oxidase A : from low resolution threading models to accurate comparative models based on crystal structures

Leonard, N., Lambert, C., Depiereux, E. & Wouters, J., 2004, Monoamine oxidases: molecular, pharmacological and neurotoxicological aspects: a tribute to professor Merton Sandler. Nicotra, A., Parvez, S. H., Glover, V., Sler, M., Parvez, S. & Minami, M. (eds.). Amsterdam: Elsevier, p. 47-61 15 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

2003

A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins

Muccioli, G. G., Poupaert, J. H., Wouters, J., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 17 Feb 2003, In : Tetrahedron. 59, 8, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

Biologie in silico: point de vue de bioinformaticiens

Lambert, C., Wouters, J., De Bolle, X. & Depiereux, E., 2003, In : Chimie nouvelle. 83, p. 106-111 6 p.

Research output: Contribution to journalArticle

Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors

Wouters, J., Oudjama, Y., Barkley, S. J., Tricot, C., Stalon, V., Droogmans, L. & Poulter, C. D., 4 Apr 2003, In : Journal of Biological Chemistry. 278, 14, p. 11903-11908 6 p.

Research output: Contribution to journalArticle

Open Access

Crystal structure of Enterobacter cloacae 908R class C β-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue

Wouters, J., Fonzé, E., Vermeire, M., Frère, J. M. & Charlier, P., 1 Aug 2003, In : Cellular and Molecular Life Sciences. 60, 8, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Monoamine oxidase A inhibitory potency and flavin perturbation are influenced by different aspects of pirlindole inhibitor structure

Hynson, R. M. G., Wouters, J. & Ramsay, R. R., 1 Jun 2003, In : Biochemical Pharmacology. 65, 11, p. 1867-1874 8 p.

Research output: Contribution to journalArticle

Preliminary X-ray crystallographic analysis of tRNA pseudouridine 55 synthase from the thermophilic eubacterium Thermotoga maritima

Wouters, J., Tricot, C., Durbecq, V., Roovers, M., Stalon, V. & Droogmans, L., 1 Jan 2003, In : Acta Crystallographica Section D: Biological Crystallography. 59, 1, p. 152-154 3 p.

Research output: Contribution to journalArticle

Open Access
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Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative

Ooms, F., Frédérick, R., Durant, F., Petzer, J. P., Castagnoli, N., Van der Schyf, C. J. & Wouters, J., 6 Jan 2003, In : Bioorganic & Medicinal Chemistry Letters. 13, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A

Massant, J., Wouters, J. & Glansdorff, N., 1 Dec 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 12, p. 2140-2149 10 p.

Research output: Contribution to journalArticle

Open Access
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Structure and mechanism of action of isopentenylpyrophosphate-dimethylallylpyrophosphate isomerase

Wouters, J., Oudjama, Y., Ghosh, S., Stalon, V., Droogmans, L. & Oldfield, E., 19 Mar 2003, In : Journal of the American Chemical Society. 125, 11, p. 3198-3199 2 p.

Research output: Contribution to journalArticle

Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins

Muccioli, G. G., Wouters, J., Poupaert, J. H., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 2 Oct 2003, In : Organic Letters. 5, 20, p. 3599-3602 4 p.

Research output: Contribution to journalArticle

Wavpred: a wavelet-based algorithm for the prediction of transmembrane proteins

Fischer, P., Baudoux, G. & Wouters, J., 2003, In : Comm. math. sci.. 1, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Yeast epiarginase regulation, an enzyme-enzyme activity control. Identification of residues of ornithine carbamoyltransferase and arginase responsible for enzyme catalytic and regulatory activities

El Alami, M., Dubois, E., Oudjama, Y., Tricot, C., Wouters, J., Stalon, V. & Messenguy, F., 13 Jun 2003, In : Journal of Biological Chemistry. 278, 24, p. 21550-21558 9 p.

Research output: Contribution to journalArticle

Open Access
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Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling

Geha, R. M., Chen, K., Wouters, J. & Shih, J. C., 10 May 2002, In : Journal of Biological Chemistry. 277, 19, p. 17209-17216 8 p.

Research output: Contribution to journalArticle

Crystallographic, NMR and ab initio calculation studies of tautomerism among substituted dihydrothiazol-2-ylhydrazones

Wouters, J., Luque, F. J., Barretta, G. U., Balzano, F., Pignatello, R. & Guccione, S., 1 Jan 2002, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB1 cannabinoid receptor ligands and potential antagonists: Synthesis, lipophilicity, affinity, and molecular modeling

Ooms, F., Wouters, J., Oscari, O., Happaerts, T., Bouchard, G., Carrupt, P. A., Testa, B. & Lambert, D. M., 25 Apr 2002, In : Journal of Medicinal Chemistry. 45, 9, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

Open Access
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