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Research Output 1992 2020

2009

Physicochemical properties of European bakery margarines with and without trans fatty acids

Cavillot, V., Pierart, C., De Meerendré, M. K., Vincent, M., Paquot, M., Wouters, J., Deroanne, C. & Danthine, S., 1 Aug 2009, In : Journal of food lipids. 16, 3, p. 273-286 14 p.

Research output: Contribution to journalArticle

Bakeries
Margarine
Trans Fatty Acids
margarine
trans fatty acids

Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor

Vandurm, P., Cauvin, C., Guiguen, A., Georges, B., Van, K. L., Martinelli, V., Cardona, C., Mbemba, G., Mouscadet, J. F., Hevesi, L., Lint, C. V. & Wouters, J., 15 Aug 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 16, p. 4806-4809 4 p.

Research output: Contribution to journalArticle

HIV Integrase Inhibitors
Integrase Inhibitors
Quinolones
Dihedral angle
Structure-Activity Relationship

Structure and X-ray conformation of pseudodesmins A and B, two new cyclic lipodepsipeptides from Pseudomonas bacteria

Sinnaeve, D., Michaux, C., Van hemel, J., Vandenkerckhove, J., Peys, E., Borremans, F. A. M., Sas, B., Wouters, J. & Martins, J. C., 23 May 2009, In : Tetrahedron. 65, 21, p. 4173-4181 9 p.

Research output: Contribution to journalArticle

Urodela
Gram-Positive Bacteria
Mucus
Methicillin-Resistant Staphylococcus aureus
Pseudomonas

Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors

Thiry, A., Delayen, A., Goossens, L., Houssin, R., Ledecq, M., Frankart, A., Dogné, J-M., Wouters, J., Supuran, C. T., Hénichart, J-P. & Masereel, B., 1 Feb 2009, In : European Journal of Medicinal Chemistry. 44, 2, p. 511-8 8 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase II
Carbonic Anhydrase I
Carbonic Anhydrase Inhibitors
Lead compounds
Molecular modeling

Synthesis and catalytic evaluation of ruthenium-arene complexes generated using imidazol(in)ium-2-carboxylates and dithiocarboxylates

Delaude, L., Sauvage, X., Demonceau, A. & Wouters, J., 27 Jul 2009, In : Organometallics. 28, 14, p. 4056-4064 9 p.

Research output: Contribution to journalArticle

Ruthenium
imidazoles
carboxylates
ruthenium
betaines

Xylanase XYL1p from Scytalidium acidophilum: Site-directed mutagenesis and acidophilic adaptation

Balaa, B. A., Brijs, K., Gebruers, K., Vandenhaute, J., Wouters, J. & Housen, I., 1 Dec 2009, In : Bioresource technology. 100, 24, p. 6465-6471 7 p.

Research output: Contribution to journalArticle

Mutagenesis
Amino acids
Enzymes
Amino Acids
Mutant Proteins
2008

A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: Expression and pharmacological comparison

Labar, G., Vliet, F. V., Wouters, J. & Lambert, D. M., 1 Jan 2008, In : Amino acids. 34, 1, p. 127-133 7 p.

Research output: Contribution to journalArticle

Fusion reactions
Pharmacology
Proteins
fatty-acid amide hydrolase
Enzymes

Application of the boron neutron capture therapy to the carbonic anhydrase IX

Deglim, J., Thiry, A., Wouters, J. & Masereel, B., 2008, Abstract book - XIII International Conference on Boron Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

A Single E141A mutation in the xylanase XYL1p from Scytalidium acidophilum improves its activity at pH 4.0

Al Balaa, B., BRIJS, K., Gebruers, K., Vandenhaute, J., Wouters, J. & Housen, I., 2008, (Unpublished)

Research output: Other contribution

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers

Graulich, A., Lamy, C., Alleva, L., Dilly, S., Chavatte, P., Wouters, J., Seutin, V. & Liégeois, J. F., 1 Jun 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 11, p. 3440-3445 6 p.

Research output: Contribution to journalArticle

Tetrahydroisoquinolines
Calcium-Activated Potassium Channels
Dequalinium
Derivatives
Neurology

Crystal structure of a cold-adapted class C β-lactamase

Michaux, C., Massant, J., Kerff, F., Frère, J. M., Docquier, J. D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J. & Wouters, J., 1 Apr 2008, In : FEBS Journal. 275, 8, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Crystal structure
Enzymes
Pseudomonas fluorescens
Temperature
Flexible structures

Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate

De Ruyck, J., Pouyez, J., Rothman, S. C., Poulter, D. & Wouters, J., 2 Sep 2008, In : Biochemistry. 47, 35, p. 9051-9053 3 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Isomerases
Crystal structure
R 97
Catalytic Domain

Estimation of sucrose crystallization kinetics from batch crystallizer data

Ouiazzane, S., Messnaoui, B., Abderafi, S., Wouters, J. & Bounahmidi, T., 15 Feb 2008, In : Journal of Crystal Growth. 310, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Crystallizers
Crystallization kinetics
sucrose
Sugar (sucrose)
Sucrose
Carbonic Anhydrase Inhibitors
Structure-Activity Relationship
Anticonvulsants
Protein Isoforms
Pharmacology
142 Downloads (Pure)

La communication pédagogique dans les exposés de chimie à l'université: Impact sur l'apprentissage des étudiants

Houart, M., Warzée, N., Wouters, J., Reniers, F. & Romainville, M., 2008, (Unpublished) Actes du 25e congrès de l'Association Internationale de Pédagogie Universitaire (AIPU) Montpellier, France (19-22 mai 2008).

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

File

Microhydration of protonated glycine: An ab initio family tree

Michaux, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 28 Feb 2008, In : Journal of physical chemistry B. 112, 8, p. 2430-2438 9 p.

Research output: Contribution to journalArticle

glycine
Glycine
Amino acids
Water
Hydration

Modeling of sucrose crystallization kinetics: The influence of glucose and fructose

Ouiazzane, S., Messnaoui, B., Abderafi, S., Wouters, J. & Bounahmidi, T., 15 Jul 2008, In : Journal of Crystal Growth. 310, 15, p. 3498-3503 6 p.

Research output: Contribution to journalArticle

Fructose
Crystallization kinetics
sucrose
Sugar (sucrose)
glucose

Modeling the microhydration of protonated alanine

Michaux, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 14 Aug 2008, In : Journal of physical chemistry B. 112, 32, p. 9896-9902 7 p.

Research output: Contribution to journalArticle

alanine
Hydration
Alanine
hydration
Molecules

Models for FFA-removal and changes in phase behavior of cocoa butter by packed column steam refining

Calliauw, G., Ayala, J. V., Gibon, V., Wouters, J., Greyt, W. D., Foubert, I. & Dewettinck, K., 1 Dec 2008, In : Journal of Food Engineering. 89, 3, p. 274-284 11 p.

Research output: Contribution to journalArticle

cocoa butter
Steam
refining
phase transition
crystallization

Monoclinic form of isopentenyl diphosphate isomerase: A case of polymorphism in biomolecular crystals

De Ruyck, J., Oudjama, Y. & Wouters, J., 29 Mar 2008, In : Acta Crystallographica Section F. 64, 4, p. 239-242 4 p.

Research output: Contribution to journalArticle

diphosphates
Isomerases
polymorphism
Polymorphism
Needles

New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H- 1-benzopyrans structurally related to (±)-cromakalim as tissue-selective pancreatic β-cell KATP channel openers

Sebille, S., de Tullio, P., Florence, X., Becker, B., Antoine, M. H., Michaux, C., Wouters, J., Pirotte, B. & Lebrun, P., 15 May 2008, In : Bioorganic and Medicinal Chemistry. 16, 10, p. 5704-5719 16 p.

Research output: Contribution to journalArticle

Cromakalim
Benzopyrans
KATP Channels
Pinacidil
Tissue

Overexpression, physicochemical characterization, and modeling of a hyperthermophilic Pyrococcus furiosus type 2 IPP isomerase

Dutoit, R., De Ruyck, J., Durisotti, V., Legrain, C., Jacobs, E. & Wouters, J., 1 Jun 2008, In : Proteins: Structure, Function and Genetics. 71, 4, p. 1699-1707 9 p.

Research output: Contribution to journalArticle

isopentenyldiphosphate delta-isomerase
Pyrococcus furiosus
Thermodynamic stability
Hot Temperature
Streptococcus pneumoniae

Protecting role of cosolvents in protein denaturation by SDS: A structural study

Michaux, C., Pouyez, J., Wouters, J. & Privé, G. G., 23 Jun 2008, In : BMC structural biology. 8, 29.

Research output: Contribution to journalArticle

Protein Denaturation
Sodium Dodecyl Sulfate
Muramidase
Proteins
Protein Refolding

Species distribution and coordination of uranyl chloro complexes in acetonitrile

Hennig, C., Servaes, K., Nockemann, P., Van Hecke, K., Van Meervelt, L., Wouters, J., Fluyt, L., Görller-Walrand, C. & Van Deun, R., 21 Apr 2008, In : Inorganic Chemistry. 47, 8, p. 2987-2993 7 p.

Research output: Contribution to journalArticle

acetonitrile
Ions
factor analysis
X ray absorption
Factor analysis

Stepwise hydration of protonated proline

Michaux, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 3 Jul 2008, In : Journal of physical chemistry B. 112, 26, p. 7702-7705 4 p.

Research output: Contribution to journalArticle

Proline
Hydration
hydration
Electron correlations
Molecules
Mevalonic Acid
Drug Design
Biosynthesis
Terpenes
Drug Delivery Systems

The crystal structure of sursassite from the Lienne Valley, Stavelot Massif, Belgium

Hatert, F., Fransolet, A. M., Wouters, J. & Bernhardt, H. J., 1 Sep 2008, In : European Journal of Mineralogy. 20, 5, p. 993-998 6 p.

Research output: Contribution to journalArticle

Aluminum
crystal structure
aluminum
Crystal structure
valley
2007

(±)-2-Benzoyl-8-ethyl-1,2-dihydroisoquinoline-1-carbonitrile: An original Reissert compound

Graulich, A., Norberg, B., Liégeois, J. F. & Wouters, J., 6 Jun 2007, In : Acta Crystallographica Section E. 63, 7

Research output: Contribution to journalArticle

Amides
Conformations
Hydrogen
rings
Hydrogen bonds

Application of the boron neutron capture therapy to the carbonic anhydrases

Deglim, J., Thiry, A., Wouters, J. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

glycine
Hydration
Glycine
hydration
Cations

Carbonic anhydrase inhibitors: synthesis, biological evaluation and rational drug design to target the tumor-associated CA IX

Thiry, A., Ledecq, M., Dogné, J-M., SUPURAN, C. T., Wouters, J. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Crystal structures of class C β-lactamases: mechanistic implications and perspectives in drug design

Bauvois, C. & Wouters, J., 2007, Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition. Robert, E., Bonomo, A. & Tolmasky, M. (eds.). Washington: ASM Press, p. 145-161 17 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling

Labar, G., Bauvois, C., Muccioli, G. G., Wouters, J. & Lambert, D. M., 23 Jul 2007, In : ChemBioChem. 8, 11, p. 1293-1297 5 p.

Research output: Contribution to journalArticle

Monoacylglycerol Lipases
Disulfiram
Enzymes
Endocannabinoids
Corrosion inhibitors

Expedient, direct synthesis of (L)Pt(0)(1,6-diene) complexes from H 2PtCl6

Berthon-Gelloz, G., Schumers, J. M., Lucaccioni, F., Tinant, B., Wouters, J. & Markó, I. E., 5 Nov 2007, In : Organometallics. 26, 23, p. 5731-5734 4 p.

Research output: Contribution to journalArticle

dienes
Ether
ethers
synthesis
methylidyne
Carbonic Anhydrases
Molecular modeling
Enantiomers
Clinical Medicine
Depolarization
Benzopyrans
Thrombin
Derivatives
Factor Xa
Chymotrypsin

Secondary nucleation study of sucrose crystallization: Experiments and modelling

Ouiazzane, S., Messnaoui, B., Wouters, J. & Bounahmidi, T., 1 Jan 2007, p. 467-473. 7 p.

Research output: Contribution to conferencePaper

Crystallizers
Sugar (sucrose)
Sucrose
Crystallization
Nucleation

Towards new leads for selective carbonic anhydrase IX inhibition: synthesis, pharmacological evaluation and combined ligand-based and target-based approach

Thiry, A., Ledecq, M., Dogné, J-M., SUPURAB, C. T., Wouters, J. & Masereel, B., 2007, Abstract Book-New Drugs and Drug Candidates : Recent Achievements in Medicinal Chemistry.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

dehydrogenases
NAD
Absorption spectra
Oxidoreductases
absorption spectra
2006
Arachidonate 5-Lipoxygenase
Lipoxygenase
Cyclooxygenase 2 Inhibitors
inhibitors
Hydrogen
Cyclization
Crystal structure
crystal structure
configurations
trifluoromethanesulfonic acid
thrombin
Guanidine
Thrombin
inhibitors
chlorides
Alizarin
Isomers
Coloring Agents
isomers
Dyes

Benefits and limits of in Silico predictions

Wouters, J., 2006, Virtual ADMET assessment in target selection and maturation. Testa, B. & Turski, L. (eds.). Amsterdam: IOS Press, Vol. 6. p. 15-28 14 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: Comparison with two original compounds, OL-92 and JP104

Michaux, C., Muccioli, G. G., Lambert, D. M. & Wouters, J., 15 Sep 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 18, p. 4772-4776 5 p.

Research output: Contribution to journalArticle

Hydantoins
Thiohydantoins
Crystal structure
Molecules
OL-92 compound
101 Downloads (Pure)
File

Determination of physical changes of inulin related to sorption isotherms: An X-ray diffraction, modulated differential scanning calorimetry and environmental scanning electron microscopy study

Ronkart, S., Blecker, C., Fougnies, C., Van Herck, J. C., Wouters, J. & Paquot, M., 3 Feb 2006, In : Carbohydrate Polymers. 63, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

Inulin
sorption isotherms
Differential Scanning Calorimetry
inulin
differential scanning calorimetry
Scytalidium
Gene encoding
Cloning
xylanases
Organism Cloning