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Research Output

2011

Interuniversity Scientific Computing Facility

Vigneron, J-P., Champagne, B., Deparis, O., Henrard, L., Lambin, P., Vercauteren, D. P., Wautelet, F. & Wouters, J., 2011, In : Nanotechnologies. p. 101-102 2 p.

Research output: Contribution to journalArticle

Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Target for Anti-Cancer Immunotherapy

Dolusic, E., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, p. Book of Abstracts, XVIIIème Journée Jeunes Chercheurs, 04/02/11, Paris, France. 1 p.

Research output: Contribution to conferencePoster

File
78 Downloads (Pure)

Pharmaceutical Salts and Co-crystals

Wouters, J. (ed.) & Quere, L. (ed.), 2011, The Royal Society of Chemistry. (RSC Drug Discovery)

Research output: Book/Report/JournalBook

SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES

Moineaux, L., Laurent, S., Dolusic, E., Reniers, J., Norberg, B., Frère, J-M., Galleni, M., Van den Eynde, B., Masereel, B., Frédérick, R. & Wouters, J., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, P20, p. 45. 1 p.

Research output: Contribution to conferencePoster

Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: New structural insight into the HIV-1 integrase inhibition

Vandurm, P., Guiguen, A., Cauvin, C., Georges, B., Le Van, K., Michaux, C., Cardona, C., Mbemba, G., Mouscadet, J. F., Hevesi, L., Van Lint, C. & Wouters, J., 1 May 2011, In : European Journal of Medicinal Chemistry. 46, 5, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Charlier, P., Laurent, S., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22. 1 p.

Research output: Contribution to conferencePoster

Synthesis and catalytic evaluation of ruthenium-arene complexes bearing imidazol(in)ium-2-thiocarboxylate ligands

Hans, M., Willem, Q., Wouters, J., Demonceau, A. & Delaude, L., 28 Nov 2011, In : Organometallics. 30, 22, p. 6133-6142 10 p.

Research output: Contribution to journalArticle

Synthesis and organocatalytic applications of imidazol(in)ium-2- thiocarboxylates

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 1 Dec 2011, In : European Journal of Organic Chemistry. 35, p. 7083-7091 9 p.

Research output: Contribution to journalArticle

THIOSEMICARBAZONES AS INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 21. 1 p.

Research output: Contribution to conferencePoster

File
154 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, p. 19. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
75 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Research output: Contribution to journalArticle

2010

An allosteric heteroditopic receptor for neutral guests and contact ion pairs with a remarkable selectivity for ammonium fluoride salts

Lascaux, A., Le Gac, S., Wouters, J., Luhmer, M. & Jabin, I., 21 Oct 2010, In : Organic and Biomolecular Chemistry. 8, 20, p. 4607-4616 10 p.

Research output: Contribution to journalArticle

Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II) Zn(II) enzyme, isopentenyl diphosphate isomerase. A parallel quantum-chemical and polarizable molecular mechanics study

Gresh, N., Audiffren, N., Piquemal, J. P., De Ruyck, J., Ledecq, M. & Wouters, J., 15 Apr 2010, In : Journal of physical chemistry B. 114, 14, p. 4884-4895 12 p.

Research output: Contribution to journalArticle

A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling

Labar, G., Wouters, J. & Lambert, D. M., 20 Aug 2010, In : Current Medicinal Chemistry . 17, 24, p. 2588-2607 20 p.

Research output: Contribution to journalArticle

Cobalt(II) complexes of nitrile-functionalized ionic liquids

Nockemann, P., Pellens, M., Van Hecke, K., Van Meervelt, L., Wouters, J., Thijs, B., Vanecht, E., Parac-Vogt, T. N., Mehdi, H., Schaltin, S., Fransaer, J., Zahn, S., Kirchner, B. & Binnemans, K., 8 Feb 2010, In : Chemistry: A European Journal. 16, 6, p. 1849-1858 10 p.

Research output: Contribution to journalArticle

Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, Séminaire des jeunes chercheurs Télévie 2011, Brussels, Belgium, 7 December 2010. 1 p.

Research output: Contribution to conferencePoster

File
66 Downloads (Pure)

Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons

Welle, A., Petrignet, J., Tinant, B., Wouters, J. & Riant, O., 24 Sep 2010, In : Chemistry: A European Journal. 16, 36, p. 10980-10983 4 p.

Research output: Contribution to journalArticle

Crystallization behavior of milk fat obtained from linseed-fed cows

Smet, K., Coudijzer, K., Fredrick, E., De Campeneere, S., De Block, J., Wouters, J., Raes, K. & Dewettinck, K., 1 Feb 2010, In : Journal of Dairy Science. 93, 2, p. 495-505 11 p.

Research output: Contribution to journalArticle

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling

Labar, G., Bauvois, C., Borel, F., Ferrer, J. L., Wouters, J. & Lambert, D. M., 25 Jan 2010, In : ChemBioChem. 11, 2, p. 218-227 10 p.

Research output: Contribution to journalArticle

Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, école doctorale SFMBBM, Liège, Belgium, 10 December 2010. 1 p.

Research output: Contribution to conferencePoster

Discovery and Optimization Of Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine-2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolusic, E., 2010, p. PC.281, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 181-182. 2 p.

Research output: Contribution to conferencePoster

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colaux, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolušić, E., 2010, In : Drugs of the future. 35, suppl A, p. 181-182

Research output: Contribution to journalLiterature review

Effect of TAG composition on the crystallization behaviour of model fat blends with the same saturated fat content

Vereecken, J., De Graef, V., Smith, K. W., Wouters, J. & Dewettinck, K., 1 Oct 2010, In : Food research international. 43, 8, p. 2057-2067 11 p.

Research output: Contribution to journalArticle

Engineering solid-state molecular switches: N-salicylidene N-heterocycle derivatives

Robert, F., Naik, A. D., Hidara, F., Tinant, B., Robiette, R., Wouters, J. & Garcia, Y., 29 Jan 2010, In : European Journal of Organic Chemistry. 4, p. 621-637 17 p.

Research output: Contribution to journalArticle

Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Promising Target forAnti-Cancer Immunotherapy

Dolusic, E., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2010, p. Book of Abstracts, XXIVth European Colloquium on Heterocyclic Chemistry, Vienna, Austria, August 23-27, 2010. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
20 Downloads (Pure)

Inhibition study of monoamine oxidases by ß-carboline derivatives.

Reniers, J., Robert, S., Frédérick, R., Masereel, B., Vincent, S. & Wouters, J., 2010, In : Drugs of the future. 35, suppl A, p. 189

Research output: Contribution to journalLiterature review

La communication pédagogique en cours magistral de chimie: Peut-on en améliorer l'efficacité ?

Houart, M., Warzée, N., Wouters, J., Reniers, F. & Romainville, M., 2010, In : Actualité Chimique. 341

Research output: Contribution to journalReview article

On the fractional crystallization of palm olein: Solid solutions and eutectic solidification

Calliauw, G., Fredrick, E., Gibon, V., Greyt, W. D., Wouters, J., Foubert, I. & Dewettinck, K., 1 May 2010, In : Food research international. 43, 4, p. 972-981 10 p.

Research output: Contribution to journalArticle

Open Access
File
31 Downloads (Pure)

Phenyl 2,3,4-tri-O-benzyl-1-thio-α-d-mannopyran-oside monohydrate

Durka, M., Norberg, B., Roué, Y., Vincent, S. P. & Wouters, J., 14 Jul 2010, In : Acta Crystallographica Section E. 66, 7

Research output: Contribution to journalArticle

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation

Mortier, J., Frederick, R., Pochet, L., Wouters, J., Masereel, B., Ganeff, C., Remouchamps, C., Piette, J., Dejardin, E. & Talaga, P., 15 May 2010, In : Biochemical Pharmacology. 79, 10, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

Qingheiite-(Fe2+), Na2Fe2+MgAl(PO 4)3, a new phosphate mineral from the Sebastião Cristino pegmatite, Minas Gerais, Brazil

Hatert, F., Baijot, M., Philippo, S. & Wouters, J., 1 May 2010, In : European Journal of Mineralogy. 22, 3, p. 459-467 9 p.

Research output: Contribution to journalArticle

Structural and enzymatic study of tryptophan 2,3-dioxgenase (TDO), a potential target in anticancer immunotherapy.

Moineaux, L., Charlier, C., Dolušić, E., Larrieu, P., Pilotte, L., Colaux, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, In : Drugs of the future. 35, suppl A, p. 189

Research output: Contribution to journalLiterature review

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218. 2 p.

Research output: Contribution to conferencePaper

Structural insights into the acidophilic pH adaptation of a novel endo-1,4-β-xylanase from Scytalidium acidophilum

Michaux, C., Pouyez, J., Mayard, A., Vandurm, P., Housen, I. & Wouters, J., 1 Oct 2010, In : Biochimie. 92, 10, p. 1407-1415 9 p.

Research output: Contribution to journalArticle

Synthesis, crystal and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, The sixth Belgian Crystallography Symposium (BCS-6), 13 October 2010, Brussels, Belgium. 1 p.

Research output: Contribution to conferencePoster

Synthesis and Evaluation of DNMT/HDAC Dual Inhibitors: in Abstracts, 24emes journées franco-belges de pharmacochimie Brussels, May 20 & 21, 2010

Boittiaux, I., BRAUN, J., STERN, E., VANDERMEERS, F., VAN DRIESSCHE, B., POUPAERT, J., WILLEMS, L., VAN LINT, C., LAMBERT, D. & Wouters, J., 2010

Research output: Other contribution

The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-L-tryptophan), a potential epigenetic modulator

Braun, J., Boittiaux, I., Tilborg, A., Lambert, D. & Wouters, J., 2010, In : Acta Crystallographica. Section E. 66, Pt 12, p. o3175-6 66 p.

Research output: Contribution to journalArticle

File
19 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, Journée scientifique de la Société royale de chimie (SRC), Gembloux, Belgium, 14 October 2010.

Research output: Contribution to conferencePoster

File
38 Downloads (Pure)
2009

Ab Initio Investigation of the Hydration of Deprotonated Amino Acids

Michaux, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 1 Apr 2009, In : Journal of the American Society for Mass Spectrometry. 20, 4, p. 632-638 7 p.

Research output: Contribution to journalArticle