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Research Output 1992 2020

2011

SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES

Moineaux, L., Laurent, S., Dolusic, E., Reniers, J., Norberg, B., Frère, J-M., Galleni, M., Van den Eynde, B., Masereel, B., Frédérick, R. & Wouters, J., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, P20, p. 45. 1 p.

Research output: Contribution to conferencePoster

Indoles
Tryptophan
Isomers
Electronic properties
Tumors
Bearings (structural)
HIV Integrase Inhibitors
Integrase Inhibitors
Integrases
Molecular modeling

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Charlier, P., Laurent, S., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 22. 1 p.

Research output: Contribution to conferencePoster

Synthesis and catalytic evaluation of ruthenium-arene complexes bearing imidazol(in)ium-2-thiocarboxylate ligands

Hans, M., Willem, Q., Wouters, J., Demonceau, A. & Delaude, L., 28 Nov 2011, In : Organometallics. 30, 22, p. 6133-6142 10 p.

Research output: Contribution to journalArticle

Bearings (structural)
Ruthenium
imidazoles
ruthenium
polymerization
Carbolines
Monoamine Oxidase Inhibitors
Monoamine Oxidase
Harmine
Derivatives
Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Monoamine Oxidase
Derivatives
Substrates

Synthesis and organocatalytic applications of imidazol(in)ium-2- thiocarboxylates

Hans, M., Wouters, J., Demonceau, A. & Delaude, L., 1 Dec 2011, In : European Journal of Organic Chemistry. 35, p. 7083-7091 9 p.

Research output: Contribution to journalArticle

imidazoles
zwitterions
Benzoin
Bearings (structural)
carbenes
Receptor, Serotonin, 5-HT1A
Molecular modeling
Binding sites
Amides
Neurons
151 Downloads (Pure)

THIOSEMICARBAZONES AS INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011), Ghent, 25 November 2011, p. 21. 1 p.

Research output: Contribution to conferencePoster

File
Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Thiosemicarbazones
Oncology
Methisazone
72 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2011, p. Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, p. 19. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Tryptophan Oxygenase
Ralstonia
Posters
Neoplasms
Tryptophan

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Research output: Contribution to journalArticle

Tryptophan Oxygenase
Indoles
Immunologic Factors
Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
2010
Proline
X-Ray Diffraction
X ray diffraction
Differential Scanning Calorimetry
Powders

An allosteric heteroditopic receptor for neutral guests and contact ion pairs with a remarkable selectivity for ammonium fluoride salts

Lascaux, A., Le Gac, S., Wouters, J., Luhmer, M. & Jabin, I., 21 Oct 2010, In : Organic and Biomolecular Chemistry. 8, 20, p. 4607-4616 10 p.

Research output: Contribution to journalArticle

Calixarenes
caps
fluorides
Salts
selectivity
diphosphates
Quantum chemistry
Isomerases
Molecular mechanics
quantum chemistry

A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling

Labar, G., Wouters, J. & Lambert, D. M., 20 Aug 2010, In : Current Medicinal Chemistry . 17, 24, p. 2588-2607 20 p.

Research output: Contribution to journalArticle

Monoacylglycerol Lipases
Endocannabinoids
Fats
Cannabinoid Receptor CB2
Cannabinoid Receptor CB1
Tetrahydroisoquinolines
Propane
Stereoisomerism
Conformations
Crystal structure

Cobalt(II) complexes of nitrile-functionalized ionic liquids

Nockemann, P., Pellens, M., Van Hecke, K., Van Meervelt, L., Wouters, J., Thijs, B., Vanecht, E., Parac-Vogt, T. N., Mehdi, H., Schaltin, S., Fransaer, J., Zahn, S., Kirchner, B. & Binnemans, K., 8 Feb 2010, In : Chemistry: A European Journal. 16, 6, p. 1849-1858 10 p.

Research output: Contribution to journalArticle

Ionic Liquids
Nitriles
Cobalt
Ionic liquids
Imides
61 Downloads (Pure)

Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, Séminaire des jeunes chercheurs Télévie 2011, Brussels, Belgium, 7 December 2010. 1 p.

Research output: Contribution to conferencePoster

File

Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons

Welle, A., Petrignet, J., Tinant, B., Wouters, J. & Riant, O., 24 Sep 2010, In : Chemistry: A European Journal. 16, 36, p. 10980-10983 4 p.

Research output: Contribution to journalArticle

Aldehydes
Copper
Carbon
3-hydroxybutanal

Crystallization behavior of milk fat obtained from linseed-fed cows

Smet, K., Coudijzer, K., Fredrick, E., De Campeneere, S., De Block, J., Wouters, J., Raes, K. & Dewettinck, K., 1 Feb 2010, In : Journal of Dairy Science. 93, 2, p. 495-505 11 p.

Research output: Contribution to journalArticle

Flax
linseed
crystallization
Crystallization
milk fat

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling

Labar, G., Bauvois, C., Borel, F., Ferrer, J. L., Wouters, J. & Lambert, D. M., 25 Jan 2010, In : ChemBioChem. 11, 2, p. 218-227 10 p.

Research output: Contribution to journalArticle

Monoacylglycerol Lipases
Endocannabinoids
Crystal structure
Catalytic Domain
Pharmaceutical Chemistry

Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, école doctorale SFMBBM, Liège, Belgium, 10 December 2010. 1 p.

Research output: Contribution to conferencePoster

Tryptophan Oxygenase
Neoplasms
Tryptophan
Ralstonia
Therapeutics

Discovery and Optimization Of Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine-2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolusic, E., 2010, p. PC.281, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 181-182. 2 p.

Research output: Contribution to conferencePoster

Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Enzyme inhibition
Tryptophan

Discovery and optimization of indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2-3 dioxygenase (IDO), a promising target for anti-cancer immunotherapy.

Frédérick, R., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colaux, D., Wouters, J., Masereel, B., Van den Eynde, B. & Dolušić, E., 2010, In : Drugs of the future. 35, suppl A, p. 181-182

Research output: Contribution to journalLiterature review

Effect of TAG composition on the crystallization behaviour of model fat blends with the same saturated fat content

Vereecken, J., De Graef, V., Smith, K. W., Wouters, J. & Dewettinck, K., 1 Oct 2010, In : Food research international. 43, 8, p. 2057-2067 11 p.

Research output: Contribution to journalArticle

crystallization
Crystallization
Fats
lipid content
lipids
Methane
sulfonates
Conformations
methane
rings

Engineering solid-state molecular switches: N-salicylidene N-heterocycle derivatives

Robert, F., Naik, A. D., Hidara, F., Tinant, B., Robiette, R., Wouters, J. & Garcia, Y., 29 Jan 2010, In : European Journal of Organic Chemistry. 4, p. 621-637 17 p.

Research output: Contribution to journalArticle

aniline
switches
Switches
engineering
Derivatives
18 Downloads (Pure)

Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Promising Target forAnti-Cancer Immunotherapy

Dolusic, E., Blanc, S., Larrieu, P., Moineaux, L., Colette, D., Fraser, G., Stroobant, V., Pilotte, L., Colau, D., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2010, p. Book of Abstracts, XXIVth European Colloquium on Heterocyclic Chemistry, Vienna, Austria, August 23-27, 2010. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Indoleamine-Pyrrole 2,3,-Dioxygenase
Immunotherapy
Neoplasms
Tryptophan
Drug Design

Inhibition study of monoamine oxidases by ß-carboline derivatives.

Reniers, J., Robert, S., Frédérick, R., Masereel, B., Vincent, S. & Wouters, J., 2010, In : Drugs of the future. 35, suppl A, p. 189

Research output: Contribution to journalLiterature review

La communication pédagogique en cours magistral de chimie: Peut-on en améliorer l'efficacité ?

Houart, M., Warzée, N., Wouters, J., Reniers, F. & Romainville, M., 2010, In : Actualité Chimique. 341

Research output: Contribution to journalReview article

On the fractional crystallization of palm olein: Solid solutions and eutectic solidification

Calliauw, G., Fredrick, E., Gibon, V., Greyt, W. D., Wouters, J., Foubert, I. & Dewettinck, K., 1 May 2010, In : Food research international. 43, 4, p. 972-981 10 p.

Research output: Contribution to journalArticle

solidification
olein
crystallization
Crystallization
crystals
31 Downloads (Pure)
Open Access
File
Brucella abortus
Inclusion Bodies
Escherichia coli
Recombinant Proteins
Bacterial Structures

Phenyl 2,3,4-tri-O-benzyl-1-thio-α-d-mannopyran-oside monohydrate

Durka, M., Norberg, B., Roué, Y., Vincent, S. P. & Wouters, J., 14 Jul 2010, In : Acta Crystallographica Section E. 66, 7

Research output: Contribution to journalArticle

Sugars
Molecules
Hydrogen bonds
sugars
Water

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation

Mortier, J., Frederick, R., Pochet, L., Wouters, J., Masereel, B., Ganeff, C., Remouchamps, C., Piette, J., Dejardin, E. & Talaga, P., 15 May 2010, In : Biochemical Pharmacology. 79, 10, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

Isoquinolines
Phosphotransferases
Chemical activation
Enzyme Inhibitors

Qingheiite-(Fe2+), Na2Fe2+MgAl(PO 4)3, a new phosphate mineral from the Sebastião Cristino pegmatite, Minas Gerais, Brazil

Hatert, F., Baijot, M., Philippo, S. & Wouters, J., 1 May 2010, In : European Journal of Mineralogy. 22, 3, p. 459-467 9 p.

Research output: Contribution to journalArticle

Phosphate minerals
new mineral
pegmatite
Minerals
X-ray diffraction

Structural and enzymatic study of tryptophan 2,3-dioxgenase (TDO), a potential target in anticancer immunotherapy.

Moineaux, L., Charlier, C., Dolušić, E., Larrieu, P., Pilotte, L., Colaux, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, In : Drugs of the future. 35, suppl A, p. 189

Research output: Contribution to journalLiterature review

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218. 2 p.

Research output: Contribution to conferencePaper

Crystal structure
Enzymes
Aspartic Acid
Catalytic Domain
Salts

Synthesis, crystal and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, The sixth Belgian Crystallography Symposium (BCS-6), 13 October 2010, Brussels, Belgium. 1 p.

Research output: Contribution to conferencePoster

Indoles
Neoplasms
Tryptophan
Ralstonia
Enzymes

Synthesis and Evaluation of DNMT/HDAC Dual Inhibitors: in Abstracts, 24emes journées franco-belges de pharmacochimie Brussels, May 20 & 21, 2010

Boittiaux, I., BRAUN, J., STERN, E., VANDERMEERS, F., VAN DRIESSCHE, B., POUPAERT, J., WILLEMS, L., VAN LINT, C., LAMBERT, D. & Wouters, J., 2010

Research output: Other contribution

18 Downloads (Pure)
File
tryptophan
Dimethylformamide
Tryptophan
Modulators
Amines
36 Downloads (Pure)

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, Journée scientifique de la Société royale de chimie (SRC), Gembloux, Belgium, 14 October 2010.

Research output: Contribution to conferencePoster

File
Tryptophan Oxygenase
Neoplasms
Tryptophan
Ralstonia
Indoleamine-Pyrrole 2,3,-Dioxygenase
2009
Hydration
alanylglycine
Amino Acids
Valine
Entropy

Assessing the potential of zwitterionic NHOCS2 adducts for probing the stereoelectronic parameters of N-heterocyclic carbenes

Delaude, L., Demonceau, A. & Wouters, J., 1 May 2009, In : European Journal of Inorganic Chemistry. 13 SPEC. ISS., p. 1882-1891 10 p.

Research output: Contribution to journalArticle

Ligands
Bearings (structural)
Nitrogen
Betaine
Atoms

A theoretical investigation of microhydration of cationic amino acids

Michaux, C., Wouters, J., Jacquemin, D. & Perpète, E. A., 22 Jun 2009, In : Chemistry Central Journal. 3, SUPPL. 1, P50.

Research output: Contribution to journalArticle

Comparing the crystallization and polymorphic behaviour of saturated and unsaturated monoglycerides

Vereecken, J., Meeussen, W., Foubert, I., Lesaffer, A., Wouters, J. & Dewettinck, K., 1 Dec 2009, In : Food research international. 42, 10, p. 1415-1425 11 p.

Research output: Contribution to journalArticle

Monoglycerides
monoacylglycerols
crystallization
Crystallization
Differential Scanning Calorimetry

Conformation-controlled networking of H-bonded assemblies on surfaces

Matena, M., Llanes-Pallas, A., Enache, M., Jung, T., Wouters, J., Champagne, B., Stöhr, M. & Bonifazi, D., 22 Jul 2009, In : Chemical Communications. 24, p. 3525-3527 3 p.

Research output: Contribution to journalArticle

Conformations
Phase transitions
Imaging techniques
Temperature
Integrase Inhibitors
human immunodeficiency virus
tautomers
Quinolones
inhibitors

Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Frederick, R., Dogné, J. M., Supuran, C. T., Wouters, J. & Masereel, B., 15 Jan 2009, In : Bioorganic and Medicinal Chemistry. 17, 2, p. 553-557 5 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase Inhibitors
Carbonic Anhydrases
Screening
Databases
Ligands