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Research Output

Article

(±)-2-Benzoyl-8-ethyl-1,2-dihydroisoquinoline-1-carbonitrile: An original Reissert compound

Graulich, A., Norberg, B., Liégeois, J. F. & Wouters, J., 6 Jun 2007, In : Acta Crystallographica Section E. 63, 7

Research output: Contribution to journalArticle

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B

Frédérick, R., Ooms, F., Castagnoli, N., Petzer, J. P., Feng, J. F., Schwarzschild, M. A., Van Der Schyf, C. J. & Wouters, J., 1 Sep 2005, In : Acta crystallographica Section C: Crystal Structure communications. 61, 9

Research output: Contribution to journalArticle

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: New templates among the CB1 cannabinoid receptor inverse agonists

Muccioli, G. G., Wouters, J., Scriba, G. K. E., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 17 Nov 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7486-7490 5 p.

Research output: Contribution to journalArticle

2,5-Diamide-substituted five-membered heterocycles: Challenging molecular synthons

Fabbro, C., Armani, S., Carloni, L. E., De Leo, F., Wouters, J. & Bonifazi, D., 2014, In : European Journal of Organic Chemistry. 2014, 25, p. 5487–5500 14 p.

Research output: Contribution to journalArticle

2,6-Dihydroxyanthraquinone: An isomer of the well known alizarin dye

De Ruyck, J., Preat, J., Perpète, E. A., Jacquemin, D. & Wouters, J., 1 Oct 2006, In : Acta Crystallographica Section E. 62, 10

Research output: Contribution to journalArticle

2-oxazolidinone

Wouters, J., Ooms, F. & Durant, F., 15 Jul 1997, In : Acta crystallographica Section C: Crystal Structure communications. 53, 7, p. 895-897 3 p.

Research output: Contribution to journalArticle

3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Frédérick, R., Robert, S., Masereel, B., Pochet, L., Pirotte, B., Charlier, C., De Ruyck, J. & Wouters, J., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7592-7603 12 p.

Research output: Contribution to journalArticle

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journalArticle

Open Access

4-Nitro-N-phthalyl-L-tryptophan

Tilborg, A., Boittiaux, I., Norberg, B., Lambert, D. & Wouters, J., 2011, In : Acta Crystallographica. Section E. 67, 8, p. o2116

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5-substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

Wouters, J. & Herdewijn, P., 7 Jun 1999, In : Bioorganic & Medicinal Chemistry Letters. 9, 11, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

6-bromo-2H-3,1-benzoxazine-2,4(1H)-dione at 153 K

Lubini, P. & Wouters, J., 15 Dec 1996, In : Acta crystallographica Section C: Crystal Structure communications. 52, 12, p. 3108-3110 3 p.

Research output: Contribution to journalArticle

7-Nitroindazole

Ooms, F., Norberg, B., Isin, E., Castagnoli, N., Van der Schyf, C. & Wouters, J., 2000, In : Acta crystallographica. Section C: Crystal structure communications. 56

Research output: Contribution to journalArticle

Ab Initio Investigation of the Hydration of Deprotonated Amino Acids

Michaux, C., Wouters, J., Perpète, E. A. & Jacquemin, D., 1 Apr 2009, In : Journal of the American Society for Mass Spectrometry. 20, 4, p. 632-638 7 p.

Research output: Contribution to journalArticle

A biomimetic heteroditopic receptor for zwitterions in protic media

Cornut, D., Moerkerke, S., Wouters, J., Bruylants, G. & Jabin, I., 2015, In : Chemistry - An Asian Journal. 10, 2, p. 440-446 7 p.

Research output: Contribution to journalArticle

Acid-base modulation of a versatile heteroditopic calix[6]arene based receptor

Cornut, D., Marrot, J., Wouters, J. & Jabin, I., 21 Sep 2011, In : Organic and Biomolecular Chemistry. 9, 18, p. 6373-6384 12 p.

Research output: Contribution to journalArticle

Acidochromic spiropyran-merocyanine stabilisation in the solid state

Seiler, V. K., Callebaut, K., Robeyns, K., Tumanov, N., Wouters, J., Champagne, B. & Leyssens, T., 1 Jan 2018, In : CrystEngComm. 20, 24, p. 3318-3327 10 p.

Research output: Contribution to journalArticle

A coloring tool for spiropyrans: Solid state metal-organic complexation: Versus salification

Seiler, V. K., Robeyns, K., Tumanov, N., Cinčić, D., Wouters, J., Champagne, B. & Leyssens, T., 10 Jul 2019, In : CrystEngComm. 21, 33, p. 4925-4933 9 p.

Research output: Contribution to journalArticle

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase

Wouters, J., Yin, F., Song, Y., Zhang, Y., Oudjama, Y., Stalon, V., Droogmans, L., Morita, C. & Oldfield, E., 2005, In : Journal of the American Chemical Society. 127, p. 536-537 2 p.

Research output: Contribution to journalArticle

Advances in pharmaceutical Co-crystal screening: Effective Co-crystal screening through structural resemblance

Springuel, G., Robeyns, K., Leyssens, T., Norberg, B. & Wouters, J., 1 Jan 2012, In : Crystal Growth and Design. 12, 1, p. 475-484 10 p.

Research output: Contribution to journalArticle

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 15 Jun 2017, In : European Journal of Pharmacology. 805, p. 25-35 11 p.

Research output: Contribution to journalArticle

Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Verbrugghen, T., Van Calenbergh, S., Vandurm, P., Pouyez, J., Wouters, J. & Maes, L., 10 Jan 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 376-380 5 p.

Research output: Contribution to journalArticle

A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: Expression and pharmacological comparison

Labar, G., Vliet, F. V., Wouters, J. & Lambert, D. M., 1 Jan 2008, In : Amino acids. 34, 1, p. 127-133 7 p.

Research output: Contribution to journalArticle

An allosteric heteroditopic receptor for neutral guests and contact ion pairs with a remarkable selectivity for ammonium fluoride salts

Lascaux, A., Le Gac, S., Wouters, J., Luhmer, M. & Jabin, I., 21 Oct 2010, In : Organic and Biomolecular Chemistry. 8, 20, p. 4607-4616 10 p.

Research output: Contribution to journalArticle

Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling

Geha, R. M., Chen, K., Wouters, J. & Shih, J. C., 10 May 2002, In : Journal of Biological Chemistry. 277, 19, p. 17209-17216 8 p.

Research output: Contribution to journalArticle

Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II) Zn(II) enzyme, isopentenyl diphosphate isomerase. A parallel quantum-chemical and polarizable molecular mechanics study

Gresh, N., Audiffren, N., Piquemal, J. P., De Ruyck, J., Ledecq, M. & Wouters, J., 15 Apr 2010, In : Journal of physical chemistry B. 114, 14, p. 4884-4895 12 p.

Research output: Contribution to journalArticle

A nano-sized container for specific encapsulation of isolated water molecules

Lavendomme, R., Marcélis, L., Wouters, J., Luhmer, M. & Jabin, I., 1 Jan 2016, In : Chemical Communications. 52, 98, p. 14109-14112 4 p.

Research output: Contribution to journalArticle

An MPP+ analog: The 2:1 N-cyclopentyl-4-phenylpyridinium bromide-4-phenylpyridine complex

Wouters, J., Evrard, G., Durant, F., Kalgutkar, A. & Castagnoli, N., 15 Apr 1996, In : Acta crystallographica Section C: Crystal Structure communications. 52, 4, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

Antagonism of the TXA2 receptor by seratrodast: A structural approach

Wouters, J., Durant, F. & Masereel, B., 4 Oct 1999, In : Bioorganic & Medicinal Chemistry Letters. 9, 19, p. 2867-2870 4 p.

Research output: Contribution to journalArticle

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Spillier, Q., Vertommen, D., Ravez, S., Marteau, R., Thémans, Q., Corbet, C., Feron, O., Wouters, J. & Frédérick, R., 18 Mar 2019, In : Scientific Reports. 9, 1, 4737.

Research output: Contribution to journalArticle

Open Access

A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules

Couvrat, N., Sanselme, M., Cartigny, Y., De Smet, F., Rome, S., Aerts, L., Quéré, L., Wouters, J. & Coquerel, G., 5 Sep 2018, In : Crystal Growth and Design. 18, 9, p. 4807-4810 4 p.

Research output: Contribution to journalArticle

A primordial RNA modification enzyme: The case of tRNA (m1A) methyltransferase

Roovers, M., Wouters, J., Bujnicki, J. M., Tricot, C., Stalon, V., Grosjean, H. & Droogmans, L., 10 Mar 2004, In : Nucleic Acids Research. 32, 2, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access

A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins

Muccioli, G. G., Poupaert, J. H., Wouters, J., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 17 Feb 2003, In : Tetrahedron. 59, 8, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

A reversible monoamine oxidase a inhibitor, befloxatone: Structural approach of its mechanism of action

Wouters, J., Moureau, F., Evrard, G., Koenig, J. J., Jegham, S., George, P. & Durant, F., 1 Aug 1999, In : Bioorganic and Medicinal Chemistry. 7, 8, p. 1683-1693 11 p.

Research output: Contribution to journalArticle

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Comparison of its Physico-Chemical Properties with those of other Inhibitors Including Brofaromine, Harmine and R40519

Moureau, F., Wouters, J., Depas, M., Vercauteren, D., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1995, In : J. Pharm. Belg.. 50, p. 269-269 1 p.

Research output: Contribution to journalArticle

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Spectrophotometric and Molecular Orbital Studies of the Interaction with Flavin Adenine Dinucleotide (FAD)

Moureau, F., Wouters, J., Vercauteren, D., Collin, S., Evrard, G., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1994, In : Eur. J. Med. Chem.. 29, p. 269-277 9 p.

Research output: Contribution to journalArticle

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Structural and Electronic Properties

Moureau, F., Wouters, J., Vercauteren, D., Collin, S., Evrard, G., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1992, In : Eur. J. Med. Chem.. 27, p. 939-948 10 p.

Research output: Contribution to journalArticle

A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling

Labar, G., Wouters, J. & Lambert, D. M., 20 Aug 2010, In : Current Medicinal Chemistry . 17, 24, p. 2588-2607 20 p.

Research output: Contribution to journalArticle

A selective calix[6]arene-based fluorescent chemosensor for phosphatidylcholine type lipids

Brunetti, E., Moerkerke, S., Wouters, J., Bartik, K. & Jabin, I., 2016, In : Organic and Biomolecular Chemistry. 14, 43, p. 10201-10207 7 p.

Research output: Contribution to journalArticle

A Simple and Efficient Mechanochemical Route for the Synthesis of Salophen Ligands and of the Corresponding Zn, Ni, and Pd Complexes

Fusaro, L., Carletta, A., Dubois, J., Tumanov, N., Aprile, C., Wouters, J., Dalla Cort, A. & Leoni, L., 1 Jan 2019, In : Molecules. 24, 12, p. 2314 11 p., 2314.

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Assessing the potential of zwitterionic NHOCS2 adducts for probing the stereoelectronic parameters of N-heterocyclic carbenes

Delaude, L., Demonceau, A. & Wouters, J., 1 May 2009, In : European Journal of Inorganic Chemistry. 13 SPEC. ISS., p. 1882-1891 10 p.

Research output: Contribution to journalArticle

A structural analysis of spiropyran and spirooxazine compounds and their polymorphs

Seiler, V. K., Tumanov, N., Robeyns, K., Wouters, J., Champagne, B. & Leyssens, T., 13 Mar 2017, In : Crystals. 7, 3, 84.

Research output: Contribution to journalArticle

Open Access