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Research Output 1992 2020

Article

(±)-2-Benzoyl-8-ethyl-1,2-dihydroisoquinoline-1-carbonitrile: An original Reissert compound

Graulich, A., Norberg, B., Liégeois, J. F. & Wouters, J., 6 Jun 2007, In : Acta Crystallographica Section E. 63, 7

Research output: Contribution to journalArticle

Amides
Conformations
Hydrogen
rings
Hydrogen bonds
Arachidonate 5-Lipoxygenase
Lipoxygenase
Cyclooxygenase 2 Inhibitors
inhibitors
Hydrogen
Cyclization
Crystal structure
crystal structure
configurations
trifluoromethanesulfonic acid

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B

Frédérick, R., Ooms, F., Castagnoli, N., Petzer, J. P., Feng, J. F., Schwarzschild, M. A., Van Der Schyf, C. J. & Wouters, J., 1 Sep 2005, In : Acta crystallographica Section C: Crystal Structure communications. 61, 9

Research output: Contribution to journalArticle

Adenosine A2 Receptor Antagonists
caffeine
adenosines
Xanthine
Monoamine Oxidase
thrombin
Guanidine
Thrombin
inhibitors
chlorides

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access
Anti-Infective Agents
Cytotoxicity
Cells
Peptidoglycan
Structure-Activity Relationship

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: New templates among the CB1 cannabinoid receptor inverse agonists

Muccioli, G. G., Wouters, J., Scriba, G. K. E., Poppitz, W., Poupaert, J. H. & Lambert, D. M., 17 Nov 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7486-7490 5 p.

Research output: Contribution to journalArticle

Phenylthiourea
Cannabinoid Receptor Agonists
Cannabinoid Receptor CB1
Phenylurea Compounds
Cannabinoid Receptor CB2
Diamide
Thiophenes
thiophenes
Conformations
Atoms
Alizarin
Isomers
Coloring Agents
isomers
Dyes

2-oxazolidinone

Wouters, J., Ooms, F. & Durant, F., 15 Jul 1997, In : Acta crystallographica Section C: Crystal Structure communications. 53, 7, p. 895-897 3 p.

Research output: Contribution to journalArticle

Oxazolidinones
Lead compounds
Static Electricity
Amines
Conformations
Factor Xa
Thrombin
hydrazine
Coumarins
Chymotrypsin
Open Access
Harmine
Quantitative Structure-Activity Relationship
Solubility
Derivatives
Cells
23 Downloads (Pure)

4-Nitro-N-phthalyl-L-tryptophan

Tilborg, A., Boittiaux, I., Norberg, B., Lambert, D. & Wouters, J., 2011, In : Acta Crystallographica. Section E. 67, 8, p. o2116

Research output: Contribution to journalArticle

File
phthalimides
tryptophan
Tryptophan
indoles
Atoms

5-substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

Wouters, J. & Herdewijn, P., 7 Jun 1999, In : Bioorganic & Medicinal Chemistry Letters. 9, 11, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Nucleosides
X ray crystallography
X Ray Crystallography
Human Herpesvirus 1

6-bromo-2H-3,1-benzoxazine-2,4(1H)-dione at 153 K

Lubini, P. & Wouters, J., 15 Dec 1996, In : Acta crystallographica Section C: Crystal Structure communications. 52, 12, p. 3108-3110 3 p.

Research output: Contribution to journalArticle

Benzoxazines
Dione
Least-Squares Analysis
Crystal structure
Crystals

7-Nitroindazole

Ooms, F., Norberg, B., Isin, E., Castagnoli, N., Van der Schyf, C. & Wouters, J., 2000, In : Acta crystallographica. Section C: Crystal structure communications. 56

Research output: Contribution to journalArticle

Hydration
alanylglycine
Amino Acids
Valine
Entropy

A biomimetic heteroditopic receptor for zwitterions in protic media

Cornut, D., Moerkerke, S., Wouters, J., Bruylants, G. & Jabin, I., 2015, In : Chemistry - An Asian Journal. 10, 2, p. 440-446 7 p.

Research output: Contribution to journalArticle

Betaine
Biomimetics
Liquids
Anserine
Thiourea

Acid-base modulation of a versatile heteroditopic calix[6]arene based receptor

Cornut, D., Marrot, J., Wouters, J. & Jabin, I., 21 Sep 2011, In : Organic and Biomolecular Chemistry. 9, 18, p. 6373-6384 12 p.

Research output: Contribution to journalArticle

Modulation
Ions
modulation
acids
Acids

Acidochromic spiropyran-merocyanine stabilisation in the solid state

Seiler, V. K., Callebaut, K., Robeyns, K., Tumanov, N., Wouters, J., Champagne, B. & Leyssens, T., 1 Jan 2018, In : CrystEngComm. 20, 24, p. 3318-3327 10 p.

Research output: Contribution to journalArticle

Inorganic acids
Stabilization
stabilization
solid state
acids

A coloring tool for spiropyrans: Solid state metal-organic complexation: Versus salification

Seiler, V. K., Robeyns, K., Tumanov, N., Cinčić, D., Wouters, J., Champagne, B. & Leyssens, T., 10 Jul 2019, In : CrystEngComm. 21, 33, p. 4925-4933 9 p.

Research output: Contribution to journalArticle

Coloring
Complexation
Metals
solid state
metals

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase

Wouters, J., Yin, F., Song, Y., Zhang, Y., Oudjama, Y., Stalon, V., Droogmans, L., Morita, C. & Oldfield, E., 2005, In : Journal of the American Chemical Society. 127, p. 536-537 2 p.

Research output: Contribution to journalArticle

Advances in pharmaceutical Co-crystal screening: Effective Co-crystal screening through structural resemblance

Springuel, G., Robeyns, K., Leyssens, T., Norberg, B. & Wouters, J., 1 Jan 2012, In : Crystal Growth and Design. 12, 1, p. 475-484 10 p.

Research output: Contribution to journalArticle

etiracetam
Drug products
Screening
screening
Crystals
Proline
X-Ray Diffraction
X ray diffraction
Differential Scanning Calorimetry
Powders

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 15 Jun 2017, In : European Journal of Pharmacology. 805, p. 25-35 11 p.

Research output: Contribution to journalArticle

norharman
Harmine
Protein Transport
Neoplasms
Protein Unfolding

Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Verbrugghen, T., Van Calenbergh, S., Vandurm, P., Pouyez, J., Wouters, J. & Maes, L., 10 Jan 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 376-380 5 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Organophosphonates
Triazoles
Amides

A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: Expression and pharmacological comparison

Labar, G., Vliet, F. V., Wouters, J. & Lambert, D. M., 1 Jan 2008, In : Amino acids. 34, 1, p. 127-133 7 p.

Research output: Contribution to journalArticle

Fusion reactions
Pharmacology
Proteins
fatty-acid amide hydrolase
Enzymes

An allosteric heteroditopic receptor for neutral guests and contact ion pairs with a remarkable selectivity for ammonium fluoride salts

Lascaux, A., Le Gac, S., Wouters, J., Luhmer, M. & Jabin, I., 21 Oct 2010, In : Organic and Biomolecular Chemistry. 8, 20, p. 4607-4616 10 p.

Research output: Contribution to journalArticle

Calixarenes
caps
fluorides
Salts
selectivity

Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling

Geha, R. M., Chen, K., Wouters, J. & Shih, J. C., 10 May 2002, In : Journal of Biological Chemistry. 277, 19, p. 17209-17216 8 p.

Research output: Contribution to journalArticle

Molecular modeling
Monoamine Oxidase
Catalytic Domain
Amino Acids
Catalyst activity
diphosphates
Quantum chemistry
Isomerases
Molecular mechanics
quantum chemistry

A nano-sized container for specific encapsulation of isolated water molecules

Lavendomme, R., Marcélis, L., Wouters, J., Luhmer, M. & Jabin, I., 1 Jan 2016, In : Chemical Communications. 52, 98, p. 14109-14112 4 p.

Research output: Contribution to journalArticle

Encapsulation
Containers
Molecules
Water
Nuclear magnetic resonance

An MPP+ analog: The 2:1 N-cyclopentyl-4-phenylpyridinium bromide-4-phenylpyridine complex

Wouters, J., Evrard, G., Durant, F., Kalgutkar, A. & Castagnoli, N., 15 Apr 1996, In : Acta crystallographica Section C: Crystal Structure communications. 52, 4, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

massively parallel processors
Bromides
bromides
analogs
Molecules

Antagonism of the TXA2 receptor by seratrodast: A structural approach

Wouters, J., Durant, F. & Masereel, B., 4 Oct 1999, In : Bioorganic & Medicinal Chemistry Letters. 9, 19, p. 2867-2870 4 p.

Research output: Contribution to journalArticle

seratrodast
Prostaglandin H2 Receptors Thromboxane A2
Sulfonamides
Crystal structure

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Spillier, Q., Vertommen, D., Ravez, S., Marteau, R., Thémans, Q., Corbet, C., Feron, O., Wouters, J. & Frédérick, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 4737.

Research output: Contribution to journalArticle

Open Access
Phosphoglycerate Dehydrogenase
Disulfiram
Alcoholism
Cysteine
Pharmaceutical Preparations

A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules

Couvrat, N., Sanselme, M., Cartigny, Y., De Smet, F., Rome, S., Aerts, L., Quéré, L., Wouters, J. & Coquerel, G., 5 Sep 2018, In : Crystal Growth and Design. 18, 9, p. 4807-4810 4 p.

Research output: Contribution to journalArticle

isomorphism
Alkanes
Paraffins
alkanes
epilepsy

A primordial RNA modification enzyme: The case of tRNA (m1A) methyltransferase

Roovers, M., Wouters, J., Bujnicki, J. M., Tricot, C., Stalon, V., Grosjean, H. & Droogmans, L., 10 Mar 2004, In : Nucleic Acids Research. 32, 2, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access
tRNA Methyltransferases
Transfer RNA
RNA
Archaea
Enzymes

A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins

Muccioli, G. G., Poupaert, J. H., Wouters, J., Norberg, B., Poppitz, W., Scriba, G. K. E. & Lambert, D. M., 17 Feb 2003, In : Tetrahedron. 59, 8, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

Thiohydantoins
Hydantoins
Phenytoin
Microwaves
Chemical activation

A reversible monoamine oxidase a inhibitor, befloxatone: Structural approach of its mechanism of action

Wouters, J., Moureau, F., Evrard, G., Koenig, J. J., Jegham, S., George, P. & Durant, F., 1 Aug 1999, In : Bioorganic and Medicinal Chemistry. 7, 8, p. 1683-1693 11 p.

Research output: Contribution to journalArticle

Monoamine Oxidase Inhibitors
Monoamine Oxidase
Coenzymes
Catalytic Domain
Oxazolidinones

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Comparison of its Physico-Chemical Properties with those of other Inhibitors Including Brofaromine, Harmine and R40519

Moureau, F., Wouters, J., Depas, M., Vercauteren, D., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1995, In : J. Pharm. Belg.. 50, p. 269-269 1 p.

Research output: Contribution to journalArticle

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Spectrophotometric and Molecular Orbital Studies of the Interaction with Flavin Adenine Dinucleotide (FAD)

Moureau, F., Wouters, J., Vercauteren, D., Collin, S., Evrard, G., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1994, In : Eur. J. Med. Chem.. 29, p. 269-277 9 p.

Research output: Contribution to journalArticle

A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Structural and Electronic Properties

Moureau, F., Wouters, J., Vercauteren, D., Collin, S., Evrard, G., Durant, F., Ducrey, F., Koenig, J-J. & Jarreau, F-X., 1992, In : Eur. J. Med. Chem.. 27, p. 939-948 10 p.

Research output: Contribution to journalArticle

A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling

Labar, G., Wouters, J. & Lambert, D. M., 20 Aug 2010, In : Current Medicinal Chemistry . 17, 24, p. 2588-2607 20 p.

Research output: Contribution to journalArticle

Monoacylglycerol Lipases
Endocannabinoids
Fats
Cannabinoid Receptor CB2
Cannabinoid Receptor CB1

A selective calix[6]arene-based fluorescent chemosensor for phosphatidylcholine type lipids

Brunetti, E., Moerkerke, S., Wouters, J., Bartik, K. & Jabin, I., 2016, In : Organic and Biomolecular Chemistry. 14, 43, p. 10201-10207 7 p.

Research output: Contribution to journalArticle

Phosphatidylcholines
lipids
Lipids
Phosphatidylethanolamines
Phospholipid Transfer Proteins
1 Downloads (Pure)

A Simple and Efficient Mechanochemical Route for the Synthesis of Salophen Ligands and of the Corresponding Zn, Ni, and Pd Complexes

Fusaro, L., Carletta, A., Dubois, J., Tumanov, N., Aprile, C., Wouters, J., Dalla Cort, A. & Leoni, L., 1 Jan 2019, In : Molecules. 24, 12, p. 2314 11 p., 2314.

Research output: Contribution to journalArticle

Open Access
File
X-Ray Diffraction
routes
Ligands
solid state
ligands
Open Access
Bond length
functionals
Density functional theory
switches
Switches

Assessing the potential of zwitterionic NHOCS2 adducts for probing the stereoelectronic parameters of N-heterocyclic carbenes

Delaude, L., Demonceau, A. & Wouters, J., 1 May 2009, In : European Journal of Inorganic Chemistry. 13 SPEC. ISS., p. 1882-1891 10 p.

Research output: Contribution to journalArticle

Ligands
Bearings (structural)
Nitrogen
Betaine
Atoms

A structural analysis of spiropyran and spirooxazine compounds and their polymorphs

Seiler, V. K., Tumanov, N., Robeyns, K., Wouters, J., Champagne, B. & Leyssens, T., 13 Mar 2017, In : Crystals. 7, 3, 84.

Research output: Contribution to journalArticle

Open Access
Polymorphism
structural analysis
Structural analysis
Hydrogen bonds
Oxazines