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Research Output

A review on the monoacylglycerol lipase: At the interface between fat and endocannabinoid signalling

Labar, G., Wouters, J. & Lambert, D. M., 20 Aug 2010, In : Current Medicinal Chemistry . 17, 24, p. 2588-2607 20 p.

Research output: Contribution to journalArticle

Aromatic Thiosemicarazones are inhibitors of tryptophan 2,3-Dioxygenase (TDO), an emerging target for cancer treatment

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, (Unpublished) p. Book of Abstracts, ASMC 11, St. Petersburg, Russia, August 21-25, 2011, P157. 1 p.

Research output: Contribution to conferencePoster

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A selective calix[6]arene-based fluorescent chemosensor for phosphatidylcholine type lipids

Brunetti, E., Moerkerke, S., Wouters, J., Bartik, K. & Jabin, I., 2016, In : Organic and Biomolecular Chemistry. 14, 43, p. 10201-10207 7 p.

Research output: Contribution to journalArticle

A Simple and Efficient Mechanochemical Route for the Synthesis of Salophen Ligands and of the Corresponding Zn, Ni, and Pd Complexes

Fusaro, L., Carletta, A., Dubois, J., Tumanov, N., Aprile, C., Wouters, J., Dalla Cort, A. & Leoni, L., 1 Jan 2019, In : Molecules. 24, 12, p. 2314 11 p., 2314.

Research output: Contribution to journalArticle

Open Access
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A Single E141A mutation in the xylanase XYL1p from Scytalidium acidophilum improves its activity at pH 4.0

Al Balaa, B., BRIJS, K., Gebruers, K., Vandenhaute, J., Wouters, J. & Housen, I., 2008, (Unpublished)

Research output: Other contribution

Open Access

Assessing the potential of zwitterionic NHOCS2 adducts for probing the stereoelectronic parameters of N-heterocyclic carbenes

Delaude, L., Demonceau, A. & Wouters, J., 1 May 2009, In : European Journal of Inorganic Chemistry. 13 SPEC. ISS., p. 1882-1891 10 p.

Research output: Contribution to journalArticle

A structural analysis of spiropyran and spirooxazine compounds and their polymorphs

Seiler, V. K., Tumanov, N., Robeyns, K., Wouters, J., Champagne, B. & Leyssens, T., 13 Mar 2017, In : Crystals. 7, 3, 84.

Research output: Contribution to journalArticle

Open Access

A structural study of the lithiophilite-sicklerite series

Hatert, F., Ottolini, L., Wouters, J. & Fontan, F., 1 Aug 2012, In : Canadian Mineralogist. 50, 4, p. 843-854 12 p.

Research output: Contribution to journalArticle

A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical

Harmsen, B., Robeyns, K., Wouters, J. & Leyssens, T., 1 May 2017, In : Journal of Pharmaceutical Sciences. 106, 5, p. 1317-1321 5 p.

Research output: Contribution to journalArticle

A theoretical investigation of microhydration of cationic amino acids

Michaux, C., Wouters, J., Jacquemin, D. & Perpète, E. A., 22 Jun 2009, In : Chemistry Central Journal. 3, SUPPL. 1, P50.

Research output: Contribution to journalArticle

A theoretical investigation of the hydrated glycine cation energetics and structures

Michaux, C., Wouters, J., Jacquemin, D. & Perpète, E. A., 4 Sep 2007, In : Chemical Physics Letters. 445, 1-3, p. 57-61 5 p.

Research output: Contribution to journalArticle

Benefits and limits of in Silico predictions

Wouters, J., 2006, Virtual ADMET assessment in target selection and maturation. Testa, B. & Turski, L. (eds.). Amsterdam: IOS Press, Vol. 6. p. 15-28 14 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: Comparison with two original compounds, OL-92 and JP104

Michaux, C., Muccioli, G. G., Lambert, D. M. & Wouters, J., 15 Sep 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 18, p. 4772-4776 5 p.

Research output: Contribution to journalArticle

Biologie in silico: point de vue de bioinformaticiens

Lambert, C., Wouters, J., De Bolle, X. & Depiereux, E., 2003, In : Chimie nouvelle. 83, p. 106-111 6 p.

Research output: Contribution to journalArticle

Bis-(1,2,3,4-tetrahydroisoquinolinium): A Chiral Scaffold for Developing High-Affinity Ligands for SK Channels

Liégeois, J. F., Wouters, J., Seutin, V. & Dilly, S., Apr 2014, In : ChemMedChem.

Research output: Contribution to journalArticle

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers

Graulich, A., Lamy, C., Alleva, L., Dilly, S., Chavatte, P., Wouters, J., Seutin, V. & Liégeois, J. F., 1 Jun 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 11, p. 3440-3445 6 p.

Research output: Contribution to journalArticle

Carbonic anhydrase inhibitors: synthesis, biological evaluation and rational drug design to target the tumor-associated CA IX

Thiry, A., Ledecq, M., Dogné, J-M., SUPURAN, C. T., Wouters, J. & Masereel, B., 2007, Abstract Book-13th Belgian Forum of Pharmaceutical Sciences.

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors

Wouters, J., Oudjama, Y., Barkley, S. J., Tricot, C., Stalon, V., Droogmans, L. & Poulter, C. D., 4 Apr 2003, In : Journal of Biological Chemistry. 278, 14, p. 11903-11908 6 p.

Research output: Contribution to journalArticle

Open Access

Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration

Badarau, E., Dilly, S., Wouters, J., Seutin, V. & Liégeois, J. F., 15 Dec 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 24, p. 5616-5620 5 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)

Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

Gillet, N., Vandermeers, F., Brogniez, A. D., Florins, A., Nigro, A., François, C., Bouzar, A-B., STERN, E., Lambert, D. M., Wouters, J. & WILLEMS, L., 15 Nov 2012, In : Plos Pathogens. 1, 2, p. 65-82 18 p.

Research output: Contribution to journalArticle

Open Access
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cis-4,6-dimethyl -2-phenyl-1,3-diselenane

Baudoux, G., Norberg, B., Wouters, J., Defrère, L., Krief, A. & Evrard, G., 15 Oct 1998, In : Acta crystallographica Section C: Crystal Structure communications. 54, 10, p. 1505-1507 3 p.

Research output: Contribution to journalArticle

coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor.

Dolusic, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2011, Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011: Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV (MedChem 2011). Vol. OC01. p. OC01

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Cobalt(II) complexes of nitrile-functionalized ionic liquids

Nockemann, P., Pellens, M., Van Hecke, K., Van Meervelt, L., Wouters, J., Thijs, B., Vanecht, E., Parac-Vogt, T. N., Mehdi, H., Schaltin, S., Fransaer, J., Zahn, S., Kirchner, B. & Binnemans, K., 8 Feb 2010, In : Chemistry: A European Journal. 16, 6, p. 1849-1858 10 p.

Research output: Contribution to journalArticle

Cocrystal formation between chiral compounds: How cocrystals differ from salts

Springuel, G., Robeyns, K., Norberg, B., Wouters, J. & Leyssens, T., 6 Aug 2014, In : Crystal Growth and Design. 14, 8, p. 3996-4004 9 p.

Research output: Contribution to journalArticle

Cocrystallization out of the blue: DL-mandelic acid/ethyl-DL-mandelate cocrystal

Tumanova, N., Payen, R., Springuel, G., Norberg, B., Robeyns, K., Le Duff, C., Wouters, J. & Leyssens, T., 5 Jan 2017, In : Journal of molecular structure. 1127, p. 397-402 6 p.

Research output: Contribution to journalArticle

Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Braga, D., Grepioni, F., Maini, L., Capucci, D., Nanna, S., Wouters, J., Aerts, L. & Quéré, L., 25 Aug 2012, In : Chemical Communications. 48, 66, p. 8219-8221 3 p.

Research output: Contribution to journalArticle

Comparing the crystallization and polymorphic behaviour of saturated and unsaturated monoglycerides

Vereecken, J., Meeussen, W., Foubert, I., Lesaffer, A., Wouters, J. & Dewettinck, K., 1 Dec 2009, In : Food research international. 42, 10, p. 1415-1425 11 p.

Research output: Contribution to journalArticle

Complex mineralogical-geochemical sequences and weathering events in the supergene ore of the Cu–Co Luiswishi deposit (Katanga, D.R. Congo)

Fontaine, L., De Putter, T., Bernard, A., Decrée, S., Cailteux, J., Wouters, J. & Yans, J., Jan 2020, In : Journal of African Earth Sciences. 161, 103674.

Research output: Contribution to journalArticle

Concentré de CHIMIE

Wouters, J., 2015, Presses universitaires de Namur. 404 p.

Research output: Book/Report/JournalBook

Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. Abstracts, Séminaire des jeunes chercheurs Télévie 2011, Brussels, Belgium, 7 December 2010. 1 p.

Research output: Contribution to conferencePoster

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Concluding remarks using piracetam as a learning model

Wouters, J., Tilborg, A. & Quéré, L., 2012, Pharmaceutical Salts and Co-crystals. Cambridge: Royal Society of Chemistry (RSC), Vol. 16. p. 330 - 337 8 p.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter

Conformational distribution of the potentially neurotoxic metabolite of haloperidol, HPP+, by NMR spectroscopy, X-ray crystallography and molecular dynamics simulations

Ooms, F., Wouters, J., Durant, F., Castagnoli, N., Van't Land, C., Dockendolf, G., Glass, T. & Van Der Schyf, C. J., 1 Dec 1997, In : Journal of the Chemical Society. Perkin Transactions 2. 12, p. 2627-2632 6 p.

Research output: Contribution to journalArticle

Conformation-controlled networking of H-bonded assemblies on surfaces

Matena, M., Llanes-Pallas, A., Enache, M., Jung, T., Wouters, J., Champagne, B., Stöhr, M. & Bonifazi, D., 22 Jul 2009, In : Chemical Communications. 24, p. 3525-3527 3 p.

Research output: Contribution to journalArticle

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
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Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons

Welle, A., Petrignet, J., Tinant, B., Wouters, J. & Riant, O., 24 Sep 2010, In : Chemistry: A European Journal. 16, 36, p. 10980-10983 4 p.

Research output: Contribution to journalArticle

Copper-Catalyzed Alkenylation of Cyanamides

Nitelet, A., Wouters, J., Dewez, D. F. & Evano, G., 1 Dec 2017, In : Organic Letters. 19, 23, p. 6276-6279 4 p.

Research output: Contribution to journalArticle

Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase

Pochet, L., Doucet, C., Dive, G., Wouters, J., Masereel, B., Reboud-Ravaux, M. & Pirotte, B., 1 Jun 2000, In : Bioorganic and Medicinal Chemistry. 8, 6, p. 1489-1501 13 p.

Research output: Contribution to journalArticle

Cristallographie à résolution temporelle (time-resolved crystallography)

Wouters, J., 1995, In : Chimie nouvelle. 13, 50, p. 1461-1468 8 p.

Research output: Contribution to journalArticle

Crystallization behavior of milk fat obtained from linseed-fed cows

Smet, K., Coudijzer, K., Fredrick, E., De Campeneere, S., De Block, J., Wouters, J., Raes, K. & Dewettinck, K., 1 Feb 2010, In : Journal of Dairy Science. 93, 2, p. 495-505 11 p.

Research output: Contribution to journalArticle

Crystallographic, NMR and ab initio calculation studies of tautomerism among substituted dihydrothiazol-2-ylhydrazones

Wouters, J., Luque, F. J., Barretta, G. U., Balzano, F., Pignatello, R. & Guccione, S., 1 Jan 2002, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

Crystallographic analysis of family 11 endo-β-l,4-xylanase Xyl1 from Streptomyces sp. S38

Wouters, J., Georis, J., Engher, D., Vandenhaute, J., Dusart, J., Frere, J. M., Depiereux, E. & Charlier, P., 31 Dec 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 12, p. 1813-1819 7 p.

Research output: Contribution to journalArticle

Crystal structure of a cold-adapted class C β-lactamase

Michaux, C., Massant, J., Kerff, F., Frère, J. M., Docquier, J. D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J. & Wouters, J., 1 Apr 2008, In : FEBS Journal. 275, 8, p. 1687-1697 11 p.

Research output: Contribution to journalArticle