Cancer immunotherapy and dual IDO/TDO inhibitors: design, synthesis, physico-chemical and biological characterizations

Mirgaux, M. & Wouters, J.

1/10/19 → 30/09/21

Project: Research

Cocrystals as an alternative to combination drugs: cocrystallization, physico-chemical characterization and structural determination of cocrystallized active pharmaceutical ingredients

Laurie, B. & Wouters, J.

1/10/19 → 30/09/21

Project: Research

Cryo- and photo-crystallography of thermo- and photochromism in the solidstate: Photo/Thermo-CoXal approach

Carletta, A. & Wouters, J.

1/10/18 → 30/09/20

Project: Research

Development of inhibitors of LDHB tetramerizatuion to block oxidative lactate metabolism and signaling in cancer

Sonveaux, P., Frédérick, R., Wouters, J. & Piel, G.

1/10/18 → 30/09/20

Project: Research

Understanding regulation mechanisms involving G-quadruplexes by crystallisation of a complex between a G-quadruplex and a protein.

De Rache, A. & Wouters, J.

1/10/17 → 30/09/20

Project: Research

Structural and inhibition study of SerB2 (Mycobacterium tuberculosis phosphoserine phosphatase)

Haufroid, M. & Wouters, J.

1/09/16 → 31/08/22

Project: PHD

Télévie: Design and enzymatic evaluation of new inhibitors of the serine metabolic pathway as potential anticancer agents : structural and functional approach of PHDGH

Wouters, J. & Themans, Q.

1/10/15 → …

Project: PHD

ARC 15/20-068: Improving the Photochromism and Thermochromism in the Solid State by Co-crystallization : an Integrated Physico-chemical Approach

Champagne, B., Wouters, J. & Leyssens, T.

1/09/15 → 31/08/20

Project: Research

PERGAMENUM21: A trans-disciplinary study of parchment: Conservation issues, historical aspects and material prospects for the 21st century

Deparis, O., Nieus, J., Hermand, X., Renard, E., Wouters, J., Chainiaux Debacq, F., Hespel, B., d'Udekem d'Acoz Gevers, M., Van Hoorebeeck, C. & Charles, C.

1/01/14 → …

Project: Research

Structural study of membrane protein TMEM45A, involved in the resistance of cancer cells against chemotherapeutic agents

Dal Maso, T. & Wouters, J.

1/10/12 → …

Project: PHD

Euroscreen: Service agreement Euroscreen

Krief, A. & Wouters, J.

25/02/04 → …

Project: Research

Conception, synthèse caractérisation physico-chimique et biologique de dérivés de l'harmine substitués par un groupement 2-méthylpyridine comme composés antiprolifératifs

Marx, S., Wouters, J. & Meinguet, C.

Project: Research

Structural approach of M.tuberculosis phosphoserine phosphatase as drug target for the design of original inhibitors

Pierson, E. & Wouters, J.

1/10/18 → 30/09/19

Project: Research

Structural study of membrane proteins involved in chemoresistance of cancer cells

Dal Maso, T. & Wouters, J.

1/01/18 → 30/09/19

Project: Research

Cocrystals as an alternative to combination drugs: cocrystallization, physico-chemical characterization and structural determination of cocrystallized active pharmaceutical ingredients

Bodart, L. & Wouters, J.

1/10/17 → 26/09/19

Project: Research

Pow(d)er XRD: Crystal structure determination through high-resolution powder diffraction

Wouters, J. & Tumanov, N.

1/01/17 → 31/12/18

Project: Research

Etude structurale de protéines membranaires impliquées dans le cancer

Rondelet, G., Dal Maso, T. & Wouters, J.

1/01/17 → 30/09/19

Project: Research

Cryo- and photo-crystallography of thermo- and photochromism in the solid-state

Wouters, J. & Carletta, A.

1/10/16 → 30/09/18

Project: Research

Improving photochromism and thermochromism in the solid state by co- crystallization: an integrated physico-chemical investigation

Wouters, J.

1/01/16 → 30/12/17

Project: Research

Télévie: Inhibition of DNA methylation: structural and functional study of the PWWP regulatory domains of DNMT 3A and B.

Wouters, J.

1/10/15 → 30/09/17

Project: Research

Télévie: Identification of chemosensitizing compounds inhibiting the resistance of taxol induced by TMEM45A protein on MDA-MB-231 cell line

Wouters, J., Michiels, C. & Marx, S.

1/10/15 → 30/09/19

Project: Research

Télévie: Design and enzymatic evaluation of new inhibitors of the serin metabolic pathway as potential anticancer agents : structural and functional approach of PHDGH and PSAT1.

Wouters, J.

1/10/15 → 30/09/17

Project: Research

Régulation de l’homéostasie du cuivre au cours des différentes étapes du développement de 3 alpha-protéobactéries

Matroule, J., Gillet, S., Devos, D. & Wouters, J.

1/10/14 → 30/09/18

Project: PHD

Crystallographic study of the mechanisms of inhibition of IDO and TDO enzymes through protein engineering: help in the design of mixed inhibitors as potential anticancer agents.

Themans, Q. & Wouters, J.

1/09/14 → 30/09/15

Project: Research

Télévie: Targeting methylation as therapy for adult T cell leukemia/lymphoma

Wouters, J.

1/10/13 → 30/09/15

Project: Research

La chiralité et les co-cristaux

Wouters, J. & Leyssens, T.

1/07/13 → 30/06/17

Project: Research

Conception, synthèse, évaluation enzymatique et rationalisation du mode d’action d’inhibiteurs réversibles des ADN méthyltransférases, en tant qu’agents anticancéreux originaux

Rondelet, G. & Wouters, J.

1/01/13 → 31/12/16

Project: PHD

synthèse et évaluation de dérivés de l'harmine

Wouters, J. & Masereel, B.

1/10/11 → 30/09/13

Project: Research

tryptophane 2,3-dioxygénase

Wouters, J.

1/10/11 → 30/09/13

Project: Research

Mechanistical study of Type 2 Isopentenyl Diphosphate Isomerase as a potential drug target.

De Ruyck, J. & Wouters, J.

1/10/11 → 30/09/14

Project: Research

Solid state synthesis of compounds of pharmaceutical interest

Dubois, J. & Wouters, J.

1/09/11 → 31/08/17

Project: PHD

Télévie: Synthesis and evaluation of analogs of harmine as potential inhibitors of DYRK1A : pro-apoptotic compounds in melanoma and gliome models

Wouters, J. & Masereel, B.

1/01/11 → 31/12/14

Project: Research

Utilisation du rayonnement synchroton

Wouters, J.

1/01/11 → 31/12/14

Project: Research

Synthèse, caractérisation physico-chimique, évaluations biologique et pharmaceutique de dérivés de l’harmine en tant qu’anticancéreux

Meinguet, C. & Wouters, J.

1/10/10 → 31/10/15

Project: PHD

Etude de l’inhibition de la 1-déoxy-D-xylulose-5-phosphate réductoisomérase (DXR)

Pouyez, J. & Wouters, J.

1/09/10 → 31/08/15

Project: PHD

Etude de dérivés beta-carbolines et 5H-indéno(1,2-c)pyridazine-5-ones en tant que modulateurs du métabolisme des monoamines: étude de l'inhibition des monoamines oxydases (MAOs)

Wouters, J. & Reniers, J.

1/09/10 → 30/09/12

Project: PHD

Etude physico-chimique et structurale du polymorphisme cristallin d'anticancéreux potentiels : la cocristallisation comme solution au problème de solubilité.

Tilborg, A. & Wouters, J.

1/10/09 → 30/09/13

Project: PHD

Les implicites dans les exposés de chimie à l’université. Identification, catégorisation et impact sur les acquis des étudiants.

Houart, M., Romainville, M., Wouters, J., Warzée, N. & Reniers, F.

1/01/09 → 31/12/10

Project: Research

Televie: Modifications épigénétiques et cancer

Wouters, J.

1/06/08 → 1/06/10

Project: Research

CANTOL: Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer

Masereel, B., Wouters, J., Dolusic, E., Frederick, R., Pouyez, J., Van den Eynde, B., Frère, J. M., Moser, M., Jean-Marie, B., Combalbert, J. & Stephenne, J.

1/04/08 → 31/03/12

Project: Research

titre en anglais

Wouters, J. & Van Durm, P.

1/10/07 → 30/09/11

Project: PHD

Ibuprofen-based microemulsions: potential applications in transdermal delivery

Destree, C. & Wouters, J.

1/10/07 → 30/09/09

Project: PHD

titre en anglais

Wouters, J. & Reniers, J.

1/10/07 → 30/09/10

Project: PHD

Structural characterization of cyclodextrins : from inclusion complexes to metal organic frameworks (MOFs)

Kossay, E. & Wouters, J.

13/02/07 → 31/12/13

Project: PHD

Functional Supramolecular Systems (PAI P6/27)

Champagne, B., Wouters, J., Botek, E., De Wergifosse, M., Guthmuller, J., Liégeois, V., Norberg, B., Plaquet, A., Staelens, N. & Vercauteren, D.

1/01/07 → 31/12/11

Project: Research

PAI P6/27: Functional supramolecular systems (FS2)

Wouters, J.

1/01/07 → 31/12/11

Project: Research

Educational communication in teaching of chemistry during the first year at the university. Measure of the effects on learning

Houart, M., Romainville, M., Wouters, J., Warzée, N. & Reniers, F.

1/01/07 → 31/12/08

Project: Research

Conception of dual inhibitors Histones deacetylase/DNA (cytosine-5) methyltransferase

Braun, J. & Wouters, J.

1/10/06 → 30/09/10

Project: PHD

PRALTER: Design and synthesis of inhibitors of the NFkB pathway for the treatment of rheumatoid arthritis

Masereel, B., Mortier, J., Wouters, J., Piette, J. & Dresse, S.

1/10/06 → 31/08/10

Project: PHD

Study of (thio)hydantoins as inhibitors of indoleamine 2,3-dioxygenase (IDO)

Fameree, M. & Wouters, J.

1/09/06 → 31/08/10

Project: PHD