• 2220 Citations
  • 24 h-Index
19992020

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2019

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Pinchuk, I., Weber, D., Kochlik, B., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T. & Lichtenberg, D., 1 Jun 2019, In : Redox Biology. 24, p. 101204 101204.

Research output: Contribution to journalArticle

Open Access

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Tomkins, J. E., Denecke, B., Musante, L., Joch, B., Debacq-Chainiaux, F., Holthofer, H., Ray, S., Huber, T. B., Dengjel, J., De Coppi, P., Widera, D. & Patel, K., 5 Apr 2019, In : Stem Cell Research and Therapy. 10, 1, p. 116 19 p., 116.

Research output: Contribution to journalArticle

Open Access
2018

Health and frailty among older spousal caregivers: an observational cohort study in Belgium

Potier, F., Degryse, J-M., Bihin, B., Chainiaux, F., Charlet-Renard, C., Martens, H. & de SAINT HUBERT, M., 26 Nov 2018, In : BMC Geriatrics. 18, 1, 91.

Research output: Contribution to journalArticle

Open Access

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study

Weinberger, B., Keller, M., Putzer, C., Breitenberger, D., Koller, B., Fiegl, S., Moreno-Villanueva, M., Bernhardt, J., Franceschi, C., Voutetakis, K., Gonos, E. S., Hurme, M., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Grune, T., Breusing, N., Bürkle, A. & Grubeck-Loebenstein, B., 1 May 2018, In : Experimental Gerontology. 105, p. 109-112 4 p.

Research output: Contribution to journalArticle

Role of Prion protein in premature senescence of human fibroblasts

Boilan, E., Winant, V., Dumortier, É., Elmoualij, B., Quatresooz, P., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 1 Mar 2018, In : Mechanisms of Ageing and Development. 170, p. 106-113 8 p.

Research output: Contribution to journalArticle

Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study

Potier, F., Degryse, J-M., Aubouy, G., Henrard, S., Bihin, B., Debacq-Chainiaux, F., MARTENS, H. J. & de SAINT HUBERT, M., 11 Aug 2018, In : The Journal of frailty & aging. 7, 3, p. 170-175 6 p.

Research output: Contribution to journalArticle

Zinc-Induced Metallothionein in Centenarian Offspring from a Large European Population: The MARK-AGE Project

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M. & 6 others, Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E. & Malavolta, M., 9 May 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 6, p. 745-753 9 p.

Research output: Contribution to journalArticle

2017

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Weber, D., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., Breusing, N., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A. & Grune, T., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 1401452.

Research output: Contribution to journalArticle

Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization

Mound, A., Lozanova, V., Warnon, C., Hermant, M., Robic, J., Guere, C., Vie, K., Lambert de Rouvroit, C., Tyteca, D., Debacq-Chainiaux, F. & Poumay, Y., 23 Jun 2017, In : Biochimica Biophysica Acta. . 1862, 9, p. 958-971 14 p.

Research output: Contribution to journalArticle

Open Access

Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis

Mellows, B., Mitchell, R., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Denecke, B., Musante, L., Ramachandra, D. L., Debacq-Chainiaux, F., Holthofer, H., Joch, B., Ray, S., Widera, D., David, A. L., Huber, T. B., Dengjel, J., De Coppi, P. & Patel, K., 15 Sep 2017, In : Stem Cells and Development. 26, 18, p. 1316-1333 18 p.

Research output: Contribution to journalArticle

2015

MARK-AGE population: From the human model to new insights

Capri, M., Moreno-Villanueva, M., Cevenini, E., Pini, E., Scurti, M., Borelli, V., Palmas, M. G., Zoli, M., Schön, C., Siepelmeyer, A., Bernhardt, J., Fiegl, S., Zondag, G., de Craen, A. J. M., Hervonen, A., Hurme, M., Sikora, E., Gonos, E. S., Voutetakis, K., Toussaint, O. & 4 others, Debacq-Chainiaux, F., Grubeck-Loebenstein, B., Bürkle, A. & Franceschi, C., 1 Nov 2015, In : Mechanisms of Ageing and Development. 151, p. 13-17 5 p.

Research output: Contribution to journalArticle

Open Access
1 Downloads (Pure)

Novel ageing-biomarker discovery using data-intensive technologies

Griffiths, H. R., Augustyniak, E. M., Bennett, S. J., Debacq-Chainiaux, F., Dunston, C. R., Kristensen, P., Melchjorsen, C. J., Navarrete, S. A., Simm, A. & Toussaint, O., 2015, In : Mechanisms of Ageing and Development. 151, p. 114-121 8 p.

Research output: Contribution to journalArticle

Open Access

Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty

Bodart, G., Goffinet, L., Morrhaye, G., Farhat, K., de Saint-Hubert, M., Debacq-Chainiaux, F., Swine, C., Geenen, V. & Martens, H. J., 1 Sep 2015, In : Annals of the New York academy of sciences. 1351, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

2013

Role of p38MAPK and oxidative stress in copper-induced senescence

Boilan, E., Winant, V., Dumortier, E., Piret, J-P., Bonfitto, F., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 2013, In : Age. 35, 6, p. 2255-71 17 p.

Research output: Contribution to journalArticle

7 Downloads (Pure)
2012

UV, stress and aging

Debacq-Chainiaux, F., Leduc, C., Verbeke, A. & Toussaint, O., 1 Jul 2012, In : Dermato-endocrinology. 4, 3, p. 236-40 5 p.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)
2011

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

Toussaint, O., Weemaels, G., Debacq-Chainiaux, F., Scharffetter-Kochanek, K. & Wlaschek, M., 1 Feb 2011, In : Journal of Cellular Physiology. 226, 2, p. 315-321 7 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Debacq-Chainiaux, F., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Apr 2011, In : Experimental Gerontology. 46, 4, p. 257-264 8 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Vo, T. K. D., de Saint-Hubert, M., Morrhaye, G., Godard, P., Geenen, V., Martens, H. J., Debacq-Chainiaux, F., Swine, C. & Toussaint, O., 1 Mar 2011, In : Mechanisms of Ageing and Development. 132, 3, p. 131-139 9 p.

Research output: Contribution to journalArticle

5 Downloads (Pure)
2010

Etablissement d'un nouveau modèle simplifié de photovieillissement du derme

Debacq-Chainiaux, F. & Toussaint, O., Jan 2010, Expression cosmétique, 1, 1, p. 96-101.

Research output: Contribution to specialist publicationArticle

File
64 Downloads (Pure)

Serum N-glycan profile shift during human ageing

Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., De Deyn, P. P., Toussaint, O., Debacq-Chainiaux, F., Poulain, M., Glupczynski, Y., Franceschi, C., Jaspers, K., van der Pluijm, I., Hoeijmakers, J. & Chen, C. C., 1 Oct 2010, In : Experimental Gerontology. 45, 10, p. 738-743 6 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Bauwens, E., Debacq-Chainiaux, F., Glupczynski, Y., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Mar 2010, In : Experimental Gerontology. 45, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Swine, C., Geenen, V., Martens, H. J., Debacq-Chainiaux, F. & Toussaint, O., 17 Aug 2010, In : Immunity and Ageing. 7, 9, 9.

Research output: Contribution to journalArticle

2009

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts

Scheckhuber, C. Q., Grief, J., Boilan, E., Luce, K., Debacq-Chainiaux, F., Rittmeyer, C., Gredilla, R., Kolbesen, B. O., Toussaint, O. & Osiewacz, H. D., 23 Mar 2009, In : PLoS ONE. 4, 3, p. 1-14 14 p., e4919.

Research output: Contribution to journalArticle

Open Access
File
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p53 and ATF-2 partly mediate the overexpression of COX-2 in H2 O2-induced premature senescence of human fibroblasts

Zdanov, S., Toussaint, O. & Debacq-Chainiaux, F., 1 Jan 2009, In : Biogerontology. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O., 1 Nov 2009, In : Nature Protocols. 4, 12, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

2008

Expression profiling of senescent-associated genes in human dermis from young and old donors. Proof-of-concept study

Borlon, C., Weemaels, G., Godard, P., Debacq-Chainiaux, F., Lemaire, P., Deroanne, C. & Toussaint, O., 1 Jun 2008, In : Biogerontology. 9, 3, p. 197-208 12 p.

Research output: Contribution to journalArticle

Prematurely senescent ARPE-19 cells display features of age-related macular degeneration

Glotin, A. L., Debacq-Chainiaux, F., Brossas, J. Y., Faussat, A. M., Tréton, J., Zubielewicz, A., Toussaint, O. & Mascarelli, F., 1 Apr 2008, In : Free Radical Biology and Medicine. 44, 7, p. 1348-1361 14 p.

Research output: Contribution to journalArticle

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts

Bigot, A., Jacquemin, V., Debacq-Chainiaux, F., Butler-Browne, G. S., Toussaint, O., Furling, D. & Mouly, V., 1 Mar 2008, In : Biology of the Cell. 100, 3, p. 189-199 11 p.

Research output: Contribution to journalArticle

Normal or stress-induced fibroblast senescence involves COX-2 activity

Zdanov, S., Debacq-Chainiaux, F., Toussaint, O., Bernard, D., Martien, S., Gosselin, K., Vercamer, C., Chelli, F. & Abbadie, C., 15 Aug 2007, In : Experimental Cell Research. 313, 14, p. 3046-3056 11 p.

Research output: Contribution to journalArticle

The gene expression profile of psoralen plus UVA-induced premature senescence in skin fibroblasts resembles a combined DNA-damage and stress-induced cellular senescence response phenotype

Borlon, C., Debacq-Chainiaux, F., Toussaint, O., Hinrichs, C., Scharffetter-Kochanek, K. & Wlaschek, M., 1 Sep 2007, In : Experimental Gerontology. 42, 9, p. 911-923 13 p.

Research output: Contribution to journalArticle

2006

Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing

Debacq-Chainiaux, F., Borlon, C., De Hertogh, B., Remacle, J., Morvan, P-Y., Vallée, R. & Toussaint, O., 1 Dec 2006, In : Journal of Pharmacy and Pharmacology. 58, 12, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

LINK-AGE: Coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology

Toussaint, O., Rayet, B., Chainiaux, F., Zouboulis, C. C., Butler-Browne, G., Chen, C. & Kirkwood, T. B. L., 1 Oct 2006, In : Mechanisms of Ageing and Development. 127, 10, p. 761-762 2 p.

Research output: Contribution to journalArticle

2005

Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays

Pascal, T., Debacq-Chainiaux, F., Chrétien, A., Bastin, C., Dabée, A. F., Bertholet, V., Remacle, J. & Toussaint, O., 27 Jul 2005, In : FEBS Letters. 579, 17, p. 3651-3659 9 p.

Research output: Contribution to journalArticle

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway

Debacq-Chainiaux, F., Borlon, C., Pascal, T., Royer, V., Eliaers, F., Ninane, N., Carrard, G., Friguet, B., de Longueville, F., Boffe, S., Remacle, J. & Toussaint, O., 15 Feb 2005, In : Journal of Cell Science. 118, 4, p. 743-758 16 p.

Research output: Contribution to journalArticle

2004

Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase

Pedro De Magalhães, J., Debacq-Chainiaux, F., De Longueville, F., Mainfroid, V., Migeot, V., Marcq, L., Remacle, J., Salmon, M. & Toussaint, O., 1 Sep 2004, In : Experimental Gerontology. 39, 9, p. 1379-1389 11 p.

Research output: Contribution to journalArticle

2003

Role of subcytotoxic stress in tissue ageing

Toussaint, O., Salmon, M., Royer, V., Dierick, J-F., Pedro de Magalhaes, J., Wenders, F., Zdanov, S., Chrétien, A., Borlon, C., Pascal, T. & Chainiaux-Debacq, F., 2003, In : Topics in current genetics. 3, p. 269-294 26 p.

Research output: Contribution to journalArticle

2002

From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing

Toussaint, O., Remacle, J., Dierick, J. F., Pascal, T., Frippiat, C., Zdanov, S., Magalhaes, J. P., Royer, V. & Chainiaux, F., 1 Nov 2002, In : The international journal of Biochemistry & Cell biology. 34, 11, p. 1415-1429 15 p.

Research output: Contribution to journalArticle

Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide

Dumont, P., Chainiaux, F., Eliaers, F., Petropoulou, C., Remacle, J., Koch-Brandt, C., Gonos, E. S. & Toussaint, O., 1 Jan 2002, In : Cell Stress and Chaperones. 7, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle