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Research Output 2000 2019

2019

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Pinchuk, I., Weber, D., Kochlik, B., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T. & Lichtenberg, D., 1 Jun 2019, In : Redox Biology. 24, p. 101204 101204.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Biomarkers
Malondialdehyde
Oxidative Stress
Antioxidants

Histone deacetylases (HDACs) and senescence

Warnon, C., Bouhjar, K., Verhoyen, M., Mottet, D., Piel, G. & Chainiaux Debacq, F., Sep 2019, Journal of Investigative Dermatology. Elsevier, p. S276

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Tomkins, J. E., Denecke, B., Musante, L., Joch, B., Debacq-Chainiaux, F., Holthofer, H., Ray, S., Huber, T. B., Dengjel, J., De Coppi, P., Widera, D. & Patel, K., 5 Apr 2019, In : Stem Cell Research and Therapy. 10, 1, p. 116 19 p., 116.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Muscle
Regeneration
Skeletal Muscle
2018

Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta

Luyten, L., Saenen, N. D., Janssen, B. G., Vrijens, K., Plusquin, M., Roels, H. A., Debacq-Chainiaux, F. & Nawrot, T. S., 1 Oct 2018, In : Environmental Research. 166, p. 310-323 14 p.

Research output: Contribution to journalReview article

Fetal Diseases
pollution exposure
Air Pollution
Air pollution
Placenta

Health and frailty among older spousal caregivers: an observational cohort study in Belgium.

Potier, F., Degryse, J-M., Bihin, B., Chainiaux, F., Charlet-Renard, C., Martens, H. & de SAINT HUBERT, M., 26 Nov 2018, In : BMC Geriatrics.

Research output: Contribution to journalArticle

Belgium
Caregivers
Observational Studies
Cohort Studies
Health

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study

Weinberger, B., Keller, M., Putzer, C., Breitenberger, D., Koller, B., Fiegl, S., Moreno-Villanueva, M., Bernhardt, J., Franceschi, C., Voutetakis, K., Gonos, E. S., Hurme, M., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Grune, T., Breusing, N., Bürkle, A. & Grubeck-Loebenstein, B., 1 May 2018, In : Experimental Gerontology. 105, p. 109-112 4 p.

Research output: Contribution to journalArticle

Diphtheria
Tetanus
Antibodies
Vaccination
Greece

Role of Prion protein in premature senescence of human fibroblasts

Boilan, E., Winant, V., Dumortier, É., Elmoualij, B., Quatresooz, P., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 1 Mar 2018, In : Mechanisms of Ageing and Development. 170, p. 106-113 8 p.

Research output: Contribution to journalArticle

Fibroblasts
Copper
Protein Isoforms
Galactosidases
Copper Sulfate

Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study

Potier, F., Degryse, J-M., Aubouy, G., Henrard, S., Bihin, B., Debacq-Chainiaux, F., MARTENS, H. J. & de SAINT HUBERT, M., 11 Aug 2018, In : The Journal of frailty & aging. 7, 3, p. 170-175 6 p.

Research output: Contribution to journalArticle

Caregivers
Case-Control Studies
Odds Ratio
Confidence Intervals
Sleep

Stress and Senescence: A Special Issue dedicated to Olivier Toussaint

Debacq-Chainiaux, F. & Gonos, E. S., 1 Mar 2018, In : Mechanisms of Ageing and Development. 170, 1 p.

Research output: Contribution to journalEditorial

Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis

Toutfaire, M., Dumortier, E., Fattaccioli, A., Van Steenbrugge, M., Proby, C. M. & Debacq-Chainiaux, F., 1 May 2018, In : International Journal of Biochemistry and Cell Biology. 98, p. 113-126 14 p.

Research output: Contribution to journalArticle

Fibroblasts
Squamous Cell Carcinoma
Carcinogenesis
Cells
Cell Line

Zinc-Induced Metallothionein in Centenarian Offspring from a Large European Population: The MARK-AGE Project

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M. & 6 others, Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E. & Malavolta, M., 9 May 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 6, p. 745-753 9 p.

Research output: Contribution to journalArticle

Metallothionein
Zinc
Population
Blood Cells
Homeostasis
2017

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Weber, D., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., Breusing, N., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A. & Grune, T., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 1401452.

Research output: Contribution to journalArticle

Biomarkers
Oxidation-Reduction
Cysteine
Oxidative stress
Tocopherols

In memory of Dr. Olivier Toussaint

Debacq-Chainiaux, F. & de Magalhães, J. P., 1 Feb 2017, In : Biogerontology. 18, 1

Research output: Contribution to journalEditorial

L’aide est-elle un stress ? Penser le travail interdisciplinaire à l’aune de la complexité

Rigaux, N., Desseilles, M., Burnay, N., Cornelis, É., Ravez, L. & Chainiaux, F., 2017, Vieillissement et entraide: Quelles méthodes pour décrire et mesurer les enjeux?. Carbonnelle, S., Eggerickx, T., Flohimont, V., Perelman, S. & Vandenhooft, A. (eds.). Univer'Cité ed. Presses Universitaires de Namur (PUN)

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization

Mound, A., Lozanova, V., Warnon, C., Hermant, M., Robic, J., Guere, C., Vie, K., Lambert de Rouvroit, C., Tyteca, D., Debacq-Chainiaux, F. & Poumay, Y., 23 Jun 2017, In : Biochimica Biophysica Acta. . 1862, 9, p. 958-971 14 p.

Research output: Contribution to journalArticle

Open Access
Re-Epithelialization
Sphingomyelins
Membrane Lipids
Keratinocytes
Cell Membrane

Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis

Mellows, B., Mitchell, R., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Denecke, B., Musante, L., Ramachandra, D. L., Debacq-Chainiaux, F., Holthofer, H., Joch, B., Ray, S., Widera, D., David, A. L., Huber, T. B., Dengjel, J., De Coppi, P. & Patel, K., 15 Sep 2017, In : Stem Cells and Development. 26, 18, p. 1316-1333 18 p.

Research output: Contribution to journalArticle

Amniotic Fluid
Regeneration
Stem Cells
Muscles
Proteins

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies.

Toutfaire, M., Bauwens, É. & Chainiaux, F., 15 Oct 2017, In : Biochemical Pharmacology. 142, p. 1-12 12 p.

Research output: Contribution to journalReview article

Skin Aging
Cell Aging
Skin
Aging of materials
Phenotype
2016

Sphingomyelin concentrates into lipid micro domains only in non-senescent cells and enhances keratinocyte migration

Mound, A., Warnon, C., Lozanova, V., Guéré, C., Vie, K., Tyteca, D., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Sep 2016, Journal of Investigative Dermatology: 46th Annual Meeting of the European Society for Dermatological Research. Elsevier, p. S178 1 p. 103

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Stress-Induced (Premature) Senescence

Debacq-Chainiaux, F., Ben Ameur, R., Bauwens, É., Dumortier, É., Toutfaire, M. & Toussaint, O., 2016, Cellular Ageing and Replicative Senescence. Rattan, S. & Hayflick, L. (eds.). The Netherlands: Springer, Vol. 4. p. 243 20 p. (Healthy Aging and Longevity; vol. 4).

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

2015

Characterization of the interaction between senescent fibroblasts and several squamous cell carcinoma cell lines

Toutfaire, M., Descamps, E., Verbeke, A. & Chainiaux, F., 29 May 2015.

Research output: Contribution to conferencePoster

Étude de l’interaction entre des fibroblastes sénescents et des cellules tumorales issues de carcinomes épidermoïdes cutanés à différents stades de tumorigenèse

Toutfaire, M., Descamps, E., Verbeke, A. & Debacq-Chainiaux, F., Jul 2015, Annales de Dermatologie et de Vénéréologie. 6-7 ed. Vol. 142. p. S290

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Étude des microvésicules relarguées par les kératinocytes humains normaux en sénescence réplicative ou induite par les UVB

Bauwens, É., Ernst, L., Leduc, C., Dieu, M. & Debacq-Chainiaux, F., Jul 2015, Annales de Dermatologie et de Vénéréologie. 6-7 ed. Vol. 142. p. S290

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Exposure of normal human keratinocytes to different sources of UVB induces premature senescence

Bauwens, É., Ernst, L., GARMYN, M. & Debacq-Chainiaux, F., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S85 1 p. 494

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Imaging membrane lipid microdomains in live human keratinocytes

Mound, A., Hermant, M., Lozanova, V., Tyteca, D., Guéré, C., Vie, K., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S47 271

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Lipid microdomains in keratinocyte membranes are characteristics of cells that do not undergo replicative senescence

Mound, A., Lozanova, V., Hermant, M., Tyteca, D., Guéré, C., Vie, K., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Dec 2015.

Research output: Contribution to conferencePoster

1 Downloads (Pure)

MARK-AGE population: From the human model to new insights

Capri, M., Moreno-Villanueva, M., Cevenini, E., Pini, E., Scurti, M., Borelli, V., Palmas, M. G., Zoli, M., Schön, C., Siepelmeyer, A., Bernhardt, J., Fiegl, S., Zondag, G., de Craen, A. J. M., Hervonen, A., Hurme, M., Sikora, E., Gonos, E. S., Voutetakis, K., Toussaint, O. & 4 others, Debacq-Chainiaux, F., Grubeck-Loebenstein, B., Bürkle, A. & Franceschi, C., 1 Nov 2015, In : Mechanisms of Ageing and Development. 151, p. 13-17 5 p.

Research output: Contribution to journalArticle

Open Access

Novel ageing-biomarker discovery using data-intensive technologies

Griffiths, H. R., Augustyniak, E. M., Bennett, S. J., Debacq-Chainiaux, F., Dunston, C. R., Kristensen, P., Melchjorsen, C. J., Navarrete, S. A., Simm, A. & Toussaint, O., 2015, In : Mechanisms of Ageing and Development. 151, p. 114-121 8 p.

Research output: Contribution to journalArticle

Open Access
Biomarkers
Technology
Cell Aging
Proteomics
T-Lymphocytes

Proteomic profile of microvesicles released by keratinocytes in replicative or in UVB-induced senescence

Bauwens, É., Ernst, L., Leduc, C., Dieu, M. & Debacq-Chainiaux, F., 29 May 2015.

Research output: Contribution to conferencePoster

Reciprocal interaction between senescent fibroblasts and squamous cell carcinoma cell lines

Toutfaire, M., Descamps, E., Verbeke, A., Toussaint, O. & Debacq-Chainiaux, F., 3 Dec 2015.

Research output: Contribution to conferencePoster

Rôle des microdomaines lipidiques lors de la sénescence des kératinocytes épidermiques

Mound, A., Hermant, M., Lozanova, V., Tyteca, D., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Jul 2015, Annales de Dermatologie et de Vénéréologie: 33e Congrès Annuel de Recherche Dermatologique (CARD). 6-7 ed. Vol. 142. p. S289

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Signal transduction in UVB- or TGF-beta1-induced premature senescence of human dermal fibroblasts

Toutfaire, M., Descamps, E., Toussaint, O. & Debacq-Chainiaux, F., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S85 1 p. 493

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty

Bodart, G., Goffinet, L., Morrhaye, G., Farhat, K., de Saint-Hubert, M., Debacq-Chainiaux, F., Swine, C., Geenen, V. & Martens, H. J., 1 Sep 2015, In : Annals of the New York academy of sciences. 1351, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Somatomedins
Growth Hormone
Interleukin-7
Aptitude
Discriminators
2013
7 Downloads (Pure)

Role of p38MAPK and oxidative stress in copper-induced senescence

Boilan, E., Winant, V., Dumortier, E., Piret, J-P., Bonfitto, F., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 2013, In : Age. 35, 6, p. 2255-71 17 p.

Research output: Contribution to journalArticle

Copper
Oxidative Stress
Antioxidants
Copper Sulfate
Lipofuscin
2012
56 Downloads (Pure)

UV, stress and aging

Debacq-Chainiaux, F., Leduc, C., Verbeke, A. & Toussaint, O., 1 Jul 2012, In : Dermato-endocrinology. 4, 3, p. 236-40 5 p.

Research output: Contribution to journalArticle

Open Access
File
Skin Aging
Cell Aging
Keratinocytes
Fibroblasts
Skin
2011
1 Downloads (Pure)

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

Toussaint, O., Weemaels, G., Debacq-Chainiaux, F., Scharffetter-Kochanek, K. & Wlaschek, M., 1 Feb 2011, In : Journal of Cellular Physiology. 226, 2, p. 315-321 7 p.

Research output: Contribution to journalArticle

Cytology
Cell Aging
Stem cells
Cell culture
Cell Biology

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Debacq-Chainiaux, F., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Apr 2011, In : Experimental Gerontology. 46, 4, p. 257-264 8 p.

Research output: Contribution to journalArticle

Geriatrics
Hip Fractures
Communicable Diseases
Preexisting Condition Coverage
Hospitalization
5 Downloads (Pure)

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Vo, T. K. D., de Saint-Hubert, M., Morrhaye, G., Godard, P., Geenen, V., Martens, H. J., Debacq-Chainiaux, F., Swine, C. & Toussaint, O., 1 Mar 2011, In : Mechanisms of Ageing and Development. 132, 3, p. 131-139 9 p.

Research output: Contribution to journalArticle

Hip Fractures
Geriatrics
Communicable Diseases
Healthy Volunteers
Heart Failure
2010

Etablissement d'un nouveau modèle simplifié de photovieillissement du derme

Debacq-Chainiaux, F. & Toussaint, O., Jan 2010, Expression cosmétique, 1, 1, p. 96-101.

Research output: Contribution to specialist publicationArticle

6 Downloads (Pure)

P38 MAPK in the senescence of human and murine fibroblasts

Debacq-Chainiaux, F., Boilan, E., Le Moutier, J. D., Weemaels, G. & Toussaint, O., 1 Dec 2010, Advances in Experimental Medicine and Biology. Vol. 694. p. 126-137 12 p. (Advances in Experimental Medicine and Biology; vol. 694).

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

Telomere Shortening
Signal transduction
MAP Kinase Signaling System
Cell Aging
p38 Mitogen-Activated Protein Kinases
64 Downloads (Pure)

Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals tripartite motif protein 29 as a survival factor

Vallery, V., Belot, N., Dieu, M., Delaive, E., Ninane, N., Demazy, C., Raes, M., Salmon, M., Poumay, Y., Debacq-Chainiaux, F. & Toussaint, O., 14 Sep 2010, In : PLoS ONE. 5, 5, e10462.

Research output: Contribution to journalArticle

File
keratinocytes
Keratinocytes
Proteomics
proteomics
Survival

Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A

Vallery, V., Boilan, E., Ninane, N., Demazy, C., Friguet, B., Toussaint, O., Poumay, Y. & Debacq-Chainiaux, F., 1 Apr 2010, In : Biogerontology. 11, 2, p. 167-181 15 p.

Research output: Contribution to journalArticle

Keratinocytes
Keratin-16
Keratin-17
Keratin-6
Galactosidases

Serum N-glycan profile shift during human ageing

Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., De Deyn, P. P., Toussaint, O., Debacq-Chainiaux, F., Poulain, M., Glupczynski, Y., Franceschi, C., Jaspers, K., van der Pluijm, I., Hoeijmakers, J. & Chen, C. C., 1 Oct 2010, In : Experimental Gerontology. 45, 10, p. 738-743 6 p.

Research output: Contribution to journalArticle

Polysaccharides
Aging of materials
Cockayne Syndrome
Biomarkers
Serum

Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Bauwens, E., Debacq-Chainiaux, F., Glupczynski, Y., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Mar 2010, In : Experimental Gerontology. 45, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsin H
Cathepsin D
Antigen Presentation
Biomarkers

Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Swine, C., Geenen, V., Martens, H. J., Debacq-Chainiaux, F. & Toussaint, O., 17 Aug 2010, In : Immunity and Ageing. 7, 9, 9.

Research output: Contribution to journalArticle

Geriatrics
Communicable Diseases
Acute-Phase Reaction
Biomarkers
Oxidative Stress
2009
21 Downloads (Pure)

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts

Scheckhuber, C. Q., Grief, J., Boilan, E., Luce, K., Debacq-Chainiaux, F., Rittmeyer, C., Gredilla, R., Kolbesen, B. O., Toussaint, O. & Osiewacz, H. D., 23 Mar 2009, In : PLoS ONE. 4, 3, p. 1-14 14 p., e4919.

Research output: Contribution to journalArticle

Open Access
File
Podospora anserina
Podospora
Fibroblasts
fibroblasts
Copper

p53 and ATF-2 partly mediate the overexpression of COX-2 in H2 O2-induced premature senescence of human fibroblasts

Zdanov, S., Toussaint, O. & Debacq-Chainiaux, F., 1 Jan 2009, In : Biogerontology. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Fibroblasts
Galactosidases
Cell Aging
Telomerase

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O., 1 Nov 2009, In : Nature Protocols. 4, 12, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

Biomarkers
beta-Galactosidase
Cell Culture Techniques
Tissue
Fluorescence
2008

Expression profiling of senescent-associated genes in human dermis from young and old donors. Proof-of-concept study

Borlon, C., Weemaels, G., Godard, P., Debacq-Chainiaux, F., Lemaire, P., Deroanne, C. & Toussaint, O., 1 Jun 2008, In : Biogerontology. 9, 3, p. 197-208 12 p.

Research output: Contribution to journalArticle

Dermis
Receptors, Tumor Necrosis Factor, Type I
Genes
Skin Aging
Selenium