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Research Output

2019

D’une sollicitation institutionnelle à une appropriation collective: Histoire d’une recherche interdisciplinaire

Burnay, N., Chainiaux Debacq, F., Cornelis, É., Desseilles, M. & Ravez, L., 2019, Les sciences sociales face à la demande des acteurs collectifs. Bresson, M., Cartier-Bresson, J. & Hirschorn, M. (eds.). Paris: Maison des Sciences de l'Homme, 54, boulevard Raspail, 75270 Paris cedex 06, Vol. 4. p. 165-176

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Pinchuk, I., Weber, D., Kochlik, B., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T. & Lichtenberg, D., 1 Jun 2019, In : Redox Biology. 24, p. 101204 101204.

Research output: Contribution to journalArticle

Open Access

Histone deacetylases (HDACs) and senescence

Warnon, C., Bouhjar, K., Verhoyen, M., Mottet, D., Piel, G. & Chainiaux Debacq, F., Sep 2019, Journal of Investigative Dermatology. Elsevier, p. S276

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Tomkins, J. E., Denecke, B., Musante, L., Joch, B., Debacq-Chainiaux, F., Holthofer, H., Ray, S., Huber, T. B., Dengjel, J., De Coppi, P., Widera, D. & Patel, K., 5 Apr 2019, In : Stem Cell Research and Therapy. 10, 1, p. 116 19 p., 116.

Research output: Contribution to journalArticle

Open Access
2018

Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta

Luyten, L., Saenen, N. D., Janssen, B. G., Vrijens, K., Plusquin, M., Roels, H. A., Debacq-Chainiaux, F. & Nawrot, T. S., 1 Oct 2018, In : Environmental Research. 166, p. 310-323 14 p.

Research output: Contribution to journalReview article

Health and frailty among older spousal caregivers: an observational cohort study in Belgium

Potier, F., Degryse, J-M., Bihin, B., Chainiaux, F., Charlet-Renard, C., Martens, H. & de SAINT HUBERT, M., 26 Nov 2018, In : BMC Geriatrics. 18, 1, 9 p., 291.

Research output: Contribution to journalArticle

Open Access
File

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study

Weinberger, B., Keller, M., Putzer, C., Breitenberger, D., Koller, B., Fiegl, S., Moreno-Villanueva, M., Bernhardt, J., Franceschi, C., Voutetakis, K., Gonos, E. S., Hurme, M., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Grune, T., Breusing, N., Bürkle, A. & Grubeck-Loebenstein, B., 1 May 2018, In : Experimental Gerontology. 105, p. 109-112 4 p.

Research output: Contribution to journalArticle

Role of Prion protein in premature senescence of human fibroblasts

Boilan, E., Winant, V., Dumortier, É., Elmoualij, B., Quatresooz, P., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 1 Mar 2018, In : Mechanisms of Ageing and Development. 170, p. 106-113 8 p.

Research output: Contribution to journalArticle

Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study

Potier, F., Degryse, J-M., Aubouy, G., Henrard, S., Bihin, B., Debacq-Chainiaux, F., MARTENS, H. J. & de SAINT HUBERT, M., 11 Aug 2018, In : The Journal of frailty & aging. 7, 3, p. 170-175 6 p.

Research output: Contribution to journalArticle

Stress and Senescence: A Special Issue dedicated to Olivier Toussaint

Debacq-Chainiaux, F. & Gonos, E. S., 1 Mar 2018, In : Mechanisms of Ageing and Development. 170, 1 p.

Research output: Contribution to journalEditorial

Zinc-Induced Metallothionein in Centenarian Offspring from a Large European Population: The MARK-AGE Project

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M. & 6 others, Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E. & Malavolta, M., 9 May 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 6, p. 745-753 9 p.

Research output: Contribution to journalArticle

2017

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Weber, D., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., Breusing, N., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A. & Grune, T., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 1401452.

Research output: Contribution to journalArticle

In memory of Dr. Olivier Toussaint

Debacq-Chainiaux, F. & de Magalhães, J. P., 1 Feb 2017, In : Biogerontology. 18, 1

Research output: Contribution to journalEditorial

L’aide est-elle un stress ? Penser le travail interdisciplinaire à l’aune de la complexité

Rigaux, N., Desseilles, M., Burnay, N., Cornelis, É., Ravez, L. & Chainiaux, F., 2017, Vieillissement et entraide: Quelles méthodes pour décrire et mesurer les enjeux?. Carbonnelle, S., Eggerickx, T., Flohimont, V., Perelman, S. & Vandenhooft, A. (eds.). Univer'Cité ed. Presses Universitaires de Namur (PUN)

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization

Mound, A., Lozanova, V., Warnon, C., Hermant, M., Robic, J., Guere, C., Vie, K., Lambert de Rouvroit, C., Tyteca, D., Debacq-Chainiaux, F. & Poumay, Y., 23 Jun 2017, In : Biochimica Biophysica Acta. . 1862, 9, p. 958-971 14 p.

Research output: Contribution to journalArticle

Open Access

Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis

Mellows, B., Mitchell, R., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M. T., Denecke, B., Musante, L., Ramachandra, D. L., Debacq-Chainiaux, F., Holthofer, H., Joch, B., Ray, S., Widera, D., David, A. L., Huber, T. B., Dengjel, J., De Coppi, P. & Patel, K., 15 Sep 2017, In : Stem Cells and Development. 26, 18, p. 1316-1333 18 p.

Research output: Contribution to journalArticle

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies.

Toutfaire, M., Bauwens, É. & Chainiaux, F., 15 Oct 2017, In : Biochemical Pharmacology. 142, p. 1-12 12 p.

Research output: Contribution to journalReview article

2016

Sphingomyelin concentrates into lipid micro domains only in non-senescent cells and enhances keratinocyte migration

Mound, A., Warnon, C., Lozanova, V., Guéré, C., Vie, K., Tyteca, D., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Sep 2016, Journal of Investigative Dermatology: 46th Annual Meeting of the European Society for Dermatological Research. Elsevier, p. S178 1 p. 103

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Stress-Induced (Premature) Senescence

Debacq-Chainiaux, F., Ben Ameur, R., Bauwens, É., Dumortier, É., Toutfaire, M. & Toussaint, O., 2016, Cellular Ageing and Replicative Senescence. Rattan, S. & Hayflick, L. (eds.). The Netherlands: Springer, Vol. 4. p. 243 20 p. (Healthy Aging and Longevity; vol. 4).

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

2015

Characterization of the interaction between senescent fibroblasts and several squamous cell carcinoma cell lines

Toutfaire, M., Descamps, E., Verbeke, A. & Chainiaux, F., 29 May 2015.

Research output: Contribution to conferencePoster

Étude de l’interaction entre des fibroblastes sénescents et des cellules tumorales issues de carcinomes épidermoïdes cutanés à différents stades de tumorigenèse

Toutfaire, M., Descamps, E., Verbeke, A. & Debacq-Chainiaux, F., Jul 2015, Annales de Dermatologie et de Vénéréologie. 6-7 ed. Vol. 142. p. S290

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Étude des microvésicules relarguées par les kératinocytes humains normaux en sénescence réplicative ou induite par les UVB

Bauwens, É., Ernst, L., Leduc, C., Dieu, M. & Debacq-Chainiaux, F., Jul 2015, Annales de Dermatologie et de Vénéréologie. 6-7 ed. Vol. 142. p. S290

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Exposure of normal human keratinocytes to different sources of UVB induces premature senescence

Bauwens, É., Ernst, L., GARMYN, M. & Debacq-Chainiaux, F., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S85 1 p. 494

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Imaging membrane lipid microdomains in live human keratinocytes

Mound, A., Hermant, M., Lozanova, V., Tyteca, D., Guéré, C., Vie, K., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S47 271

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Lipid microdomains in keratinocyte membranes are characteristics of cells that do not undergo replicative senescence

Mound, A., Lozanova, V., Hermant, M., Tyteca, D., Guéré, C., Vie, K., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Dec 2015.

Research output: Contribution to conferencePoster

MARK-AGE population: From the human model to new insights

Capri, M., Moreno-Villanueva, M., Cevenini, E., Pini, E., Scurti, M., Borelli, V., Palmas, M. G., Zoli, M., Schön, C., Siepelmeyer, A., Bernhardt, J., Fiegl, S., Zondag, G., de Craen, A. J. M., Hervonen, A., Hurme, M., Sikora, E., Gonos, E. S., Voutetakis, K., Toussaint, O. & 4 others, Debacq-Chainiaux, F., Grubeck-Loebenstein, B., Bürkle, A. & Franceschi, C., 1 Nov 2015, In : Mechanisms of Ageing and Development. 151, p. 13-17 5 p.

Research output: Contribution to journalArticle

Open Access
1 Downloads (Pure)

Novel ageing-biomarker discovery using data-intensive technologies

Griffiths, H. R., Augustyniak, E. M., Bennett, S. J., Debacq-Chainiaux, F., Dunston, C. R., Kristensen, P., Melchjorsen, C. J., Navarrete, S. A., Simm, A. & Toussaint, O., 2015, In : Mechanisms of Ageing and Development. 151, p. 114-121 8 p.

Research output: Contribution to journalArticle

Open Access

Reciprocal interaction between senescent fibroblasts and squamous cell carcinoma cell lines

Toutfaire, M., Descamps, E., Verbeke, A., Toussaint, O. & Debacq-Chainiaux, F., 3 Dec 2015.

Research output: Contribution to conferencePoster

Rôle des microdomaines lipidiques lors de la sénescence des kératinocytes épidermiques

Mound, A., Hermant, M., Lozanova, V., Tyteca, D., Lambert De Rouvroit, C., Debacq-Chainiaux, F. & Poumay, Y., Jul 2015, Annales de Dermatologie et de Vénéréologie: 33e Congrès Annuel de Recherche Dermatologique (CARD). 6-7 ed. Vol. 142. p. S289

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Signal transduction in UVB- or TGF-beta1-induced premature senescence of human dermal fibroblasts

Toutfaire, M., Descamps, E., Toussaint, O. & Debacq-Chainiaux, F., Sep 2015, Journal of Investigative Dermatology: 45th Annual Meeting of the European Society for Dermatological Research. S2 ed. Vol. 135. p. S85 1 p. 493

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty

Bodart, G., Goffinet, L., Morrhaye, G., Farhat, K., de Saint-Hubert, M., Debacq-Chainiaux, F., Swine, C., Geenen, V. & Martens, H. J., 1 Sep 2015, In : Annals of the New York academy of sciences. 1351, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

2013

Role of p38MAPK and oxidative stress in copper-induced senescence

Boilan, E., Winant, V., Dumortier, E., Piret, J-P., Bonfitto, F., Osiewacz, H. D., Debacq-Chainiaux, F. & Toussaint, O., 2013, In : Age. 35, 6, p. 2255-71 17 p.

Research output: Contribution to journalArticle

7 Downloads (Pure)
2012

UV, stress and aging

Debacq-Chainiaux, F., Leduc, C., Verbeke, A. & Toussaint, O., 1 Jul 2012, In : Dermato-endocrinology. 4, 3, p. 236-40 5 p.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)
2011

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

Toussaint, O., Weemaels, G., Debacq-Chainiaux, F., Scharffetter-Kochanek, K. & Wlaschek, M., 1 Feb 2011, In : Journal of Cellular Physiology. 226, 2, p. 315-321 7 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Debacq-Chainiaux, F., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Apr 2011, In : Experimental Gerontology. 46, 4, p. 257-264 8 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Vo, T. K. D., de Saint-Hubert, M., Morrhaye, G., Godard, P., Geenen, V., Martens, H. J., Debacq-Chainiaux, F., Swine, C. & Toussaint, O., 1 Mar 2011, In : Mechanisms of Ageing and Development. 132, 3, p. 131-139 9 p.

Research output: Contribution to journalArticle

5 Downloads (Pure)
2010

Etablissement d'un nouveau modèle simplifié de photovieillissement du derme

Debacq-Chainiaux, F. & Toussaint, O., Jan 2010, Expression cosmétique, 1, 1, p. 96-101.

Research output: Contribution to specialist publicationArticle

P38 MAPK in the senescence of human and murine fibroblasts

Debacq-Chainiaux, F., Boilan, E., Le Moutier, J. D., Weemaels, G. & Toussaint, O., 1 Dec 2010, Advances in Experimental Medicine and Biology. Vol. 694. p. 126-137 12 p. (Advances in Experimental Medicine and Biology; vol. 694).

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

6 Downloads (Pure)
File
114 Downloads (Pure)

Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A

Vallery, V., Boilan, E., Ninane, N., Demazy, C., Friguet, B., Toussaint, O., Poumay, Y. & Debacq-Chainiaux, F., 1 Apr 2010, In : Biogerontology. 11, 2, p. 167-181 15 p.

Research output: Contribution to journalArticle

Serum N-glycan profile shift during human ageing

Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., De Deyn, P. P., Toussaint, O., Debacq-Chainiaux, F., Poulain, M., Glupczynski, Y., Franceschi, C., Jaspers, K., van der Pluijm, I., Hoeijmakers, J. & Chen, C. C., 1 Oct 2010, In : Experimental Gerontology. 45, 10, p. 738-743 6 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Bauwens, E., Debacq-Chainiaux, F., Glupczynski, Y., Swine, C., Geenen, V., Martens, H. J. & Toussaint, O., 1 Mar 2010, In : Experimental Gerontology. 45, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

Vo, T. K. D., Godard, P., de Saint-Hubert, M., Morrhaye, G., Swine, C., Geenen, V., Martens, H. J., Debacq-Chainiaux, F. & Toussaint, O., 17 Aug 2010, In : Immunity and Ageing. 7, 9, 9.

Research output: Contribution to journalArticle

2009

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts

Scheckhuber, C. Q., Grief, J., Boilan, E., Luce, K., Debacq-Chainiaux, F., Rittmeyer, C., Gredilla, R., Kolbesen, B. O., Toussaint, O. & Osiewacz, H. D., 23 Mar 2009, In : PLoS ONE. 4, 3, p. 1-14 14 p., e4919.

Research output: Contribution to journalArticle

Open Access
File
22 Downloads (Pure)

p53 and ATF-2 partly mediate the overexpression of COX-2 in H2 O2-induced premature senescence of human fibroblasts

Zdanov, S., Toussaint, O. & Debacq-Chainiaux, F., 1 Jan 2009, In : Biogerontology. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O., 1 Nov 2009, In : Nature Protocols. 4, 12, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

2008

Expression profiling of senescent-associated genes in human dermis from young and old donors. Proof-of-concept study

Borlon, C., Weemaels, G., Godard, P., Debacq-Chainiaux, F., Lemaire, P., Deroanne, C. & Toussaint, O., 1 Jun 2008, In : Biogerontology. 9, 3, p. 197-208 12 p.

Research output: Contribution to journalArticle