• 5260 Citations
  • 40 h-Index
1989 …2020

Research output per year

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Research Output

2017

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 15 Jun 2017, In : European Journal of Pharmacology. 805, p. 25-35 11 p.

Research output: Contribution to journalArticle

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 1 Jun 2017, In : Data in Brief. 12, p. 546-551 6 p.

Research output: Contribution to journalArticle

2015

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 Apr 2015, In : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726.

Research output: Contribution to journalArticle

Open Access
2014

Thiosemicarbazide Derivatives as Novel Indolamine-2,3-dioxygenase (IDO) Inhibitors

Serra, S., Moineaux, L., Vancraeynest, C., Masereel, B., Pochet, L., Wouters, J. & Frédérick, R., 2014, Chemmedchem EFMC-ISMC 2014 Book of Abstracts. p. 280

Research output: Contribution in Book/Catalog/Report/Conference proceedingConference contribution

2013

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Dolušić, E., Pilotte, L., Moineaux, L., Larrieu, P., Stroobant, V., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B., Lanners, S. & Frédérick, R., 27 May 2013, p. Book of Abstracts, Heterocycles in Bio-organic Chemistry, Riga, Latvia, 27 - 30 May 2013, PO129. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
97 Downloads (Pure)

Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 Jan 2013, In : Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

3 Downloads (Pure)

New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides

Rogez-Florent, T., Meignan, S., Foulon, C., Six, P., Gros, A., Bal-Mahieu, C., Supuran, C. T., Scozzafava, A., Frédérick, R., Masereel, B., Depreux, P., Lansiaux, A., Goossens, J. F., Gluszok, S. & Goossens, L., 15 Mar 2013, In : Bioorganic and Medicinal Chemistry. 21, 6, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

2012

Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: an in vitro and in vivo study

Marega, R., Karmani, L., Flamant, L., Nageswaran, P. G., Valembois, V., Masereel, B., Feron, O., Vander Borght, T., Lucas, S., Michiels, C., Gallez, B. & Bonifazi, D., 2012, In : Journal of Materials Chemistry. 22, 39, p. 21305-21312 8 p.

Research output: Contribution to journalArticle

Open Access
File
110 Downloads (Pure)

Convenient one-pot formation of highly functionalized 5-halothiazoles

Dolusic, E., Modaffari, S., Pochet, L., Wouters, J., Masereel, B. & Frédérick, R., 1 Jul 2012, p. Book of Abstracts, Balticum Organicum Syntheticum, July 1-4 2012, Tallinn, Estonia, PO27, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
59 Downloads (Pure)
2 Downloads (Pure)
1 Downloads (Pure)

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 Jul 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Research output: Contribution to journalArticle

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B. & Van Den Eynde, B. J., 14 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2497-2502 6 p.

Research output: Contribution to journalArticle

Open Access
File
57 Downloads (Pure)

Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colaux, D., Van den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 2012, In : ChemMedChem. p. 371 1 p.

Research output: Contribution to journalLiterature review

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J-M., Masereel, B., Frédérick, R. & Wouters, J., 1 Aug 2012, In : European Journal of Medicinal Chemistry. 54, p. 95-102 8 p.

Research output: Contribution to journalArticle

Open Access
File
141 Downloads (Pure)

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Dolusic, E., Larrieu, P., Moineaux, L., Strobant, V., Pilotte, L., Colau, D., Pochet, L., De Plaen, E., Uyttenhove, C., Van den Eynde, B., Wouters, J., Masereel, B. & Frédérick, R., 15 Jul 2012, p. Programme & Book of Abstracts, BOSS XIII, KU Leuven, Belgium, 15 - 20 July 2012, P292, p. 339. 1 p.

Research output: Contribution to conferencePoster

File
237 Downloads (Pure)
1 Downloads (Pure)
2011

A CONVENIENT FORMATION OF HIGHLY FUNCTIONALIZED 5-BROMO-1,3-THIAZOLES.

Dolusic, E., Modaffari, S., Wouters, J., Masereel, B. & Frédérick, R., 2011, p. Book of Abstracts, 15th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, 1-2 December 2011, p. 25. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
69 Downloads (Pure)

Antibody immobilization on gold nanoparticles coated layer-by-layer with polyelectrolytes

Masereel, B., Dinguizli, M., Moniotte, N., Bouzin, C., Feron, O., Gallez, B., Vander Borght, T., Michiels, C. & Lucas, S., 1 Apr 2011, In : Journal of Nanoparticle Research. 13, 4, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

Anti-virulence strategy against Brucella suis: Synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors

Abdo, M-R., Turtaut, F., Montero, J-L., Winum, J-Y., Joseph, P., Köhler, S., Mortier, J. & Masereel, B., 21 May 2011, In : Organic and Biomolecular Chemistry. 9, 10, p. 3681-3690 10 p.

Research output: Contribution to journalArticle

Aromatic Thiosemicarazones are inhibitors of tryptophan 2,3-Dioxygenase (TDO), an emerging target for cancer treatment

Dolusic, E., Modaffari, S., Larrieu, P., Vancraeynest, C., Pilotte, L., Colau, D., Stroobant, V., Wouters, J., Masereel, B., Van den Eynde, B. & Frédérick, R., 2011, (Unpublished) p. Book of Abstracts, ASMC 11, St. Petersburg, Russia, August 21-25, 2011, P157. 1 p.

Research output: Contribution to conferencePoster

File
82 Downloads (Pure)

BM-573 inhibits the development of early atherosclerotic lesions in Apo e deficient mice by blocking TP receptors and thromboxane synthase

Cherdon, C., Ooms, A., Sakalihassan, N., Defraigne, J-O., Rolin, S., Michiels, C., Masereel, B., Dogné, J-M., Hanson, J., Pirotte, B., De Leval, L. & Drion, P., 2011, In : Prostaglandins and Other Lipid Mediators. 94, p. 124-132 9 p.

Research output: Contribution to journalArticle

Carbon nanoparticles synthesized by sputtering and gas condensation inside a nanocluster source of fixed dimension

Bouchat, V., Feron, O., Gallez, B., Masereel, B., Michiels, C., Vander Borght, T., Rossi, F. & Lucas, S., 2011, In : Surface and Coatings Technology. 205, S2, p. S577-S581

Research output: Contribution to journalArticle

4 Downloads (Pure)

Chemical reactivity of Plasma Polymerized Allylamine (PPAA) thin films on Au and Si: study of the thickness influence and ageing of the films

Moreau, N., Feron, O., Gallez, B., Masereel, B., Michiels, C., Vander Borght, T., Rossi, F. & Lucas, S., 25 Jul 2011, In : Surface and Coatings Technology. 205, SUPPL. 2, p. S462-S465

Research output: Contribution to journalArticle