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Research Output 2009 2019

  • 526 Citations
  • 12 h-Index
  • 21 Article
  • 1 Review article
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Article
2019

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Deschênes-Simard, X., Parisotto, M., Rowell, M. C., Le Calvé, B., Igelmann, S., Moineau-Vallée, K., Saint-Germain, E., Kalegari, P., Bourdeau, V., Kottakis, F., Bardeesy, N. & Ferbeyre, G., 1 Apr 2019, In : Aging Cell. 18, 2, p. e12889 15 p., e12889.

Research output: Contribution to journalArticle

Open Access
Metformin
Oncogenes
Cell Aging
Stem Cells
Neoplasms

NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor

Bury, M., Le Calve, B., Lessard, F., Dal Maso, T., Saliba, J., Michiels, C., Febeyre, G. & Vloker, B., 5 Nov 2019, In : Cell Reports. 29, 6, p. 1469-1481.e9

Research output: Contribution to journalArticle

Open Access
File
Cyclin-Dependent Kinases
Cell proliferation
Cell growth
Colonic Neoplasms
Tumors
2018
6 Downloads (Pure)
Open Access
File
Protons
Macrophages
Phenotype
Neoplasms
Radiotherapy

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Lessard, F., Igelmann, S., Trahan, C., Huot, G., Saint-Germain, E., Mignacca, L., Del Toro, N., Lopes-Paciencia, S., Le Calve, B., Montero, M., Deschënes-Simard, X., Bury, M., Moiseeva, O., Rowell, M-C., Oeffinger, M., Zorca, C. E., Zenklusen, D., Brakier-Gingras, L., Bourdeau, V. & Ferbeyre, G., 1 Jul 2018, In : nature cell biology. 20, 7, p. 789-799 11 p.

Research output: Contribution to journalArticle

Cell Aging
Cell Cycle Checkpoints
Ribosomes
Cyclin-Dependent Kinase 4
Ribosomal Proteins

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

Le Calve, B., 1 Dec 2018, In : Aging Cell. 17, 6, 12 p., e12835.

Research output: Contribution to journalArticle

Open Access
Phospholipase A2 Receptors
Geranyltranstransferase
Premature Aging
Progeria
Cell Aging
2016

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

Le Calvé, B., Griveau, A., Vindrieux, D., Maréchal, R., Wiel, C., Svrcek, M., Gout, J., Azzi, L., Payen, L., Cros, J., de la Fouchardière, C., Dubus, P., Guitton, J., Bartholin, L., Bachet, J-B. & Bernard, D., 2016, In : Oncotarget. 7, 22, p. 32100-12 13 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Adenocarcinoma
gemcitabine
Drug Therapy
Pharmaceutical Preparations

Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape

Wiel, C., Gras, B., Vindrieux, D., Warnier, M., Gitenay, D., Le Calvé, B., Ferrand, M., Augert, A. & Bernard, D., 2016, In : Oncogene. 35, 12, p. 1596-601 6 p.

Research output: Contribution to journalArticle

Neoplasms
Drug Therapy
Skin
multidrug resistance protein 3
Knockout Mice

The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action

Griveau, A., Devailly, G., Eberst, L., Navaratnam, N., Le Calvé, B., Ferrand, M., Faull, P., Augert, A., Dante, R., Vanacker, J. M., Vindrieux, D. & Bernard, D., 2016, In : Oncogene. 35, 38, p. 5033-42 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Up-Regulation
Neoplasms
Mitochondrial DNA
Phospholipase A2 Receptors
2014

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

Wiel, C., Lallet-Daher, H., Gitenay, D., Gras, B., Le Calvé, B., Augert, A., Ferrand, M., Prevarskaya, N., Simonnet, H., Vindrieux, D. & Bernard, D., 2014, In : Nature Communications. 5, p. 3792

Research output: Contribution to journalArticle

inositols
Inositol 1,4,5-Trisphosphate Receptors
endoplasmic reticulum
Endoplasmic Reticulum
calcium

Quantification of β-aminopropionitrile, an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry

Machon, C., Le Calve, B., Coste, S., Riviere, M., Payen, L., Bernard, D. & Guitton, J., 2014, In : Biomedical chromatography : BMC. 28, 7, p. 1017-23 7 p.

Research output: Contribution to journalArticle

Aminopropionitrile
Protein-Lysine 6-Oxidase
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

Vindrieux, D., Devailly, G., Augert, A., Le Calvé, B., Ferrand, M., Pigny, P., Payen, L., Lambeau, G., Perrais, M., Aubert, S., Simonnet, H., Dante, R. & Bernard, D., 2014, In : Oncotarget. 5, 4, p. 1004-13 10 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Growth
Neoplasms
Phospholipase A2 Receptors
Secretory Phospholipase A2
2013

Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis

Wiel, C., Augert, A., Vincent, D. F., Gitenay, D., Vindrieux, D., Le Calvé, B., Arfi, V., Lallet-Daher, H., Reynaud, C., Treilleux, I., Bartholin, L., Lelievre, E. & Bernard, D., 2013, In : Cell Death and Disease. 4, p. e855

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Carcinogenesis
Focal Adhesion Protein-Tyrosine Kinases
Cell Aging
Transgenic Mice

PLA2R1 kills cancer cells by inducing mitochondrial stress

Augert, A., Vindrieux, D., Girard, C. A., Le Calvé, B., Gras, B., Ferrand, M., Bouchet, B. P., Puisieux, A., de Launoit, Y., Simonnet, H., Lambeau, G. & Bernard, D., 2013, In : Free Radicals in Biology and Medicine. 65, p. 969-77 9 p.

Research output: Contribution to journalArticle

Secretory Phospholipase A2
Cell death
Cells
Reactive Oxygen Species
Cell Death

PLA2R1 mediates tumor suppression by activating JAK2

Vindrieux, D., Augert, A., Girard, C. A., Gitenay, D., Lallet-Daher, H., Wiel, C., Le Calve, B., Gras, B., Ferrand, M., Verbeke, S., De Launoit, Y., Leroy, X., Puisieux, A., Aubert, S., Perrais, M., Gelb, M., Simonnet, H., Lambeau, G. & Bernard, D., 15 Oct 2013, In : Cancer Research. 73, 20, p. 6334-6345 12 p.

Research output: Contribution to journalArticle

Open Access
Oncogenes
Neoplasms
Phospholipase A2 Receptors
Carcinogenesis
Cell Aging

Potassium channel KCNA1 modulates oncogene-induced senescence and transformation

Lallet-Daher, H., Wiel, C., Gitenay, D., Navaratnam, N., Augert, A., Le Calvé, B., Verbeke, S., Carling, D., Aubert, S., Vindrieux, D. & Bernard, D., 2013, In : Cancer Research. 73, 16, p. 5253-65 13 p.

Research output: Contribution to journalArticle

Kv1.1 Potassium Channel
Oncogenes
Cyclic AMP-Dependent Protein Kinases
Membrane Potentials
Carcinogenesis
2010

Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression

Le Calvé, B., Rynkowski, M., Le Mercier, M., Bruyère, C., Lonez, C., Gras, T., Haibe-Kains, B., Bontempi, G., Decaestecker, C., Ruysschaert, J-M., Kiss, R. & Lefranc, F., 2010, In : Neoplasia (New York, N.Y.). 12, 9, p. 727-39 13 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Up-Regulation
Enzymes
Astrocytoma

Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells

Lamoral-Theys, D., Le Mercier, M., Le Calvé, B., Rynkowski, M. A., Bruyère, C., Decaestecker, C., Haibe-Kains, B., Bontempi, G., Dubois, J., Lefranc, F. & Kiss, R., 2010, In : Neoplasia (New York, N.Y.). 12, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

temozolomide
Oligodendroglioma
Therapeutics
Glioma

Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

Rives, A., Le Calvé, B., Delaine, T., Legentil, L., Kiss, R. & Delfourne, E., 2010, In : European Journal of Medicinal Chemistry. 45, 1, p. 343-51 9 p.

Research output: Contribution to journalArticle

Pyrroloiminoquinones
Alkaloids
Ethanol
Cells
Cell Line
2009

7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents

Azéma, J., Guidetti, B., Dewelle, J., Le Calve, B., Mijatovic, T., Korolyov, A., Vaysse, J., Malet-Martino, M., Martino, R. & Kiss, R., 2009, In : Bioorganic & medicinal chemistry. 17, 15, p. 5396-407 12 p.

Research output: Contribution to journalArticle

Ciprofloxacin
Antineoplastic Agents
Derivatives
Cell Line
Cells

Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight

Lamoral-Theys, D., Andolfi, A., Van Goietsenoven, G., Cimmino, A., Le Calvé, B., Wauthoz, N., Mégalizzi, V., Gras, T., Bruyère, C., Dubois, J., Mathieu, V., Kornienko, A., Kiss, R. & Evidente, A., 2009, In : Journal of Medicinal Chemistry. 52, 20, p. 6244-56 13 p.

Research output: Contribution to journalArticle

Amaryllidaceae Alkaloids
Phenanthridines
Structure-Activity Relationship
Neoplasms
Melanoma