Research Output 1989 2019

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2019

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Spillier, Q., Vertommen, D., Ravez, S., Marteau, R., Thémans, Q., Corbet, C., Feron, O., Wouters, J. & Frédérick, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 4737.

Research output: Contribution to journalArticle

Open Access
Phosphoglycerate Dehydrogenase
Disulfiram
Alcoholism
Cysteine
Pharmaceutical Preparations

Anticoagulation With an Inhibitor of Factors XIa and XIIa During Cardiopulmonary Bypass

Pireaux, V., Tassignon, J., Demoulin, S., Derochette, S., Borenstein, N., Ente, A., Fiette, L., Douxfils, J., Lancellotti, P., Guyaux, M. & Godfroid, E., 29 Oct 2019, In : Journal of the American College of Cardiology. 74, 17, p. 2178-2189 12 p.

Research output: Contribution to journalArticle

Factor XIa
Factor XIIa
Ixodes
Cardiopulmonary Bypass
Heparin

Assessment of the analytical performances and sample stability on ST Genesia system using the STG-DrugScreen application

Douxfils, J., Morimont, L., Bouvy, C., de Saint-Hubert, M., Devalet, B., Devroye, C., Dincq, A-S., Dogné, J-M., Guldenpfennig, M., Baudar, J., Larock, A-S., Lessire, S. & Mullier, F., 2019, In : Journal of thrombosis and haemostasis : JTH.

Research output: Contribution to journalArticle

Thrombin
Freezing
Reference Values
Low Molecular Weight Heparin
Anticoagulants
Coagulants
Partial Thromboplastin Time
Prothrombin Time
Blood Coagulation Factors

Determinants of the Quality of Warfarin Control after Venous Thromboembolism and Validation of the SAMe-TT2-R2 Score: An Analysis of Hokusai-VTE

Barco, S., Granziera, S., Coppens, M., Douxfils, J., Nijkeuter, M., Riva, N., Vanassche, T., Zhang, G., Lin, M., Kamphuisen, P. W., Cohen, A. T. & Beyer-Westendorf, J., 2019, In : Thrombosis and Haemostasis. 119, 4, p. 675-684 10 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Warfarin
Quality Control
Vitamin K
Hemorrhage
Chromogenics
Plasmas
Heparin
Assays
Low Molecular Weight Heparin

Growth performance and immune status in common carp Cyprinus carpio as affected by plant oil-based diets complemented with β-glucan

Nguyen, T. M., Mandiki, S. N. M., Tran, T. N. T., Larondelle, Y., Mellery, J., Mignolet, E., Cornet, V., Flamion, E. & Kestemont, P., 1 Sep 2019, In : Fish and Shellfish Immunology. 92, p. 288-299 12 p.

Research output: Contribution to journalArticle

plant fats and oils
Plant Oils
Glucans
glucans
Nutrition

Multiscale dynamical embeddings of complex networks

Schaub, M. T., Delvenne, J. C., Lambiotte, R. & Barahona, M., 20 Jun 2019, In : Physical Review E. 99, 6, 18 p., 062308.

Research output: Contribution to journalArticle

Complex Networks
embedding
Control Theory
control theory
Vertex of a graph

Temporal Sequence of Retweets Help to Detect Influential Nodes in Social Networks

Bhowmick, A. K., Gueuning, M., Delvenne, J. C., Lambiotte, R. & Mitra, B., 1 Jun 2019, In : IEEE Transactions on Computational Social Systems. 6, 3, p. 441-455 15 p., 8692729.

Research output: Contribution to journalArticle

Social Networks
social network
Vertex of a graph
Anchors
twitter
2018

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio

Ameryckx, A., Thabault, L., Pochet, L., Leimanis, S., Poupaert, J., Wouters, J., Joris, B., Van Bambeke, F. & Frederick, R., 5 Nov 2018, In : European journal of medicinal chemistry / Chimica therapeutica. 159, 5, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access
Anti-Infective Agents
Cytotoxicity
Cells
Peptidoglycan
Structure-Activity Relationship
20 Downloads (Pure)
File
Hemostasis
Viper Venoms
Thrombin Time
Coagulants
Partial Thromboplastin Time
Open Access
Lymphoma, Large B-Cell, Diffuse
MicroRNAs
Longitudinal Studies
Biomarkers
Clinical Studies

Constraints from microlensing experiments on clustered primordial black holes

García-Bellido, J. & Clesse, S., 1 Mar 2018, In : Physics of the Dark Universe. 19, p. 144-148 5 p.

Research output: Contribution to journalArticle

experiment
dark matter
mass distribution
anisotropy
power spectra
Thromboxane B2
Liquid chromatography
Platelets
Tandem Mass Spectrometry
Liquid Chromatography

Enhancing action of positive allosteric modulators through the design of dimeric compounds

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, J. S. & Pirotte, B., 28 Jun 2018, In : Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

Research output: Contribution to journalArticle

Benzothiadiazines
Ligands
Ethane
AMPA Receptors
HEK293 Cells

EudraVigilance Medicines Safety Database: Publicly Accessible Data for Research and Public Health Protection

Postigo, R., Brosch, S., Slattery, J., van Haren, A., Dogné, J. M., Kurz, X., Candore, G., Domergue, F. & Arlett, P., 1 Jul 2018, In : Drug Safety. 41, 7, p. 665-675 11 p.

Research output: Contribution to journalArticle

Open Access
Public health
Medicine
Pharmacovigilance
Public Health
Databases

Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests

Favresse, J., Lardinois, B., Sabor, L., Devalet, B., Vandepapeliere, J., Braibant, M., Lessire, S., Chatelain, B., Jacqmin, H., Douxfils, J. & Mullier, F., 2018, In : TH Open. 2, 2, p. e202-e209

Research output: Contribution to journalArticle

Thrombophilia
Anticoagulants
Lupus Coagulation Inhibitor
Prothrombin Time
Antithrombin Proteins

International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants

Gosselin, R. C., Adcock, D. M., Bates, S. M., Douxfils, J., Favaloro, E. J., Gouin-Thibault, I., Guillermo, C., Kawai, Y., Lindhoff-Last, E. & Kitchen, S., 1 Mar 2018, In : Thrombosis and Haemostasis. 118, 3, p. 437-450 14 p.

Research output: Contribution to journalArticle

Open Access
Hematology
Anticoagulants
Point-of-Care Systems
Partial Thromboplastin Time
Prothrombin Time

Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study

Sennesael, A. L., Larock, A. S., Devalet, B., Mathieux, V., Verschuren, F., Muschart, X., Dalleur, O., Dogné, J. M. & Spinewine, A., 1 Jul 2018, In : British Journal of Clinical Pharmacology. 84, 7, p. 1544-1556 13 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Anticoagulants
Prospective Studies
Vitamin K
Hemorrhage

Primordial black holes survive SN lensing constraints

García-Bellido, J., Clesse, S. & Fleury, P., 1 Jun 2018, In : Physics of the Dark Universe. 20, p. 95-100 6 p.

Research output: Contribution to journalArticle

supernovae
dark matter
Hubble diagram
diagram
LIGO (observatory)

Reduction of the turn-around time for the measurement of rivaroxaban and apixaban: Assessment of the performance of a rapid centrifugation method

Dincq, A. S., Lessire, S., Pirard, G., Siriez, R., Guldenpfennig, M., Baudar, J., Favresse, J., Douxfils, J. & Mullier, F., 1 Dec 2018, In : International Journal of Laboratory Hematology. 40, 6, p. e105-e108 4 p.

Research output: Contribution to journalArticle

3 Downloads (Pure)

Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study

Sennesael, A-L., Larock, A-S., Douxfils, J., Elens, L., Stillemans, G., Wiesen, M., Taubert, M., Dogné, J-M., Spinewine, A. & Mullier, F., 12 Nov 2018, In : Thrombosis journal. 16, 1, p. 28 28.

Research output: Contribution to journalArticle

Open Access
File
Prospective Studies
Hemorrhage
Anticoagulants
Hospital Emergency Service
Pharmacokinetics

The anticoagulant effect of dabigatran is reflected in the lag time and time-to-peak, but not in the endogenous thrombin potential or peak, of thrombin generation

Bloemen, S., Zwaveling, S., Douxfils, J., Roest, M., Kremers, R. & Mullier, F., 1 Nov 2018, In : Thrombosis Research. 171, p. 160-166 7 p.

Research output: Contribution to journalArticle

Thrombin
Anticoagulants
Artifacts
Dabigatran
Calibration
2017

An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants

Sennesael, A-L., Exner, T., Chatelain, B., Lessire, S., Larock, A-S., Vancraeynest, C., Pochet, L., Dogné, J-M., Spinewine, A., Mullier, F. & Douxfils, J., 1 Sep 2017, In : Thrombosis Research. 157, p. 29-37 9 p.

Research output: Contribution to journalArticle

Prothrombin Time
Anticoagulants
Vitamin K
International Normalized Ratio
Tandem Mass Spectrometry
Electrochemistry
hemolysis
Nanopowder
Platelets
Coagulation
24 Downloads (Pure)

Development and evaluation of injectable nanosized drug delivery systems for apigenin

Reatul, K., Palazzo, C., Laloy, J., Delvigne, A-S., Vanslambrouck, S., Jérôme, C., Lepeltier, E., Orange, F., Dogne, J-M., Evrard, B., Passirani, C. & Piel, G., 5 Nov 2017, In : International Journal of Pharmaceutics. 532, 2, p. 757-768 12 p.

Research output: Contribution to journalArticle

Open Access
File
Nanocapsules
Apigenin
Drug Delivery Systems
Injections
Liposomes

Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway

Bouckaert, C., Zhu, S., Govers-Riemslag, J. W. P., Depoorter, M., Diamond, S. L. & Pochet, L., 1 Sep 2017, In : Thrombosis Research. 157, p. 126-133 8 p.

Research output: Contribution to journalArticle

Coumarins
Factor XIIa
Thrombosis
Water
Plasma Kallikrein
Paroxysmal Hemoglobinuria
Longitudinal Studies
Blood Platelets
Thrombin
Phospholipids

Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin

Farcas, E., Bouckaert, C., Servais, A. C., Hanson, J., Pochet, L. & Fillet, M., 1 Sep 2017, In : Analytica chimica acta. 984, p. 211-222 12 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
Drug Discovery
Thrombin
electrokinesis

PEGylated and functionalized aliphatic polycarbonate polyplex nanoparticles for intravenous administration of HDAC5 siRNA in cancer therapy

Frère, A., Baroni, A., Hendrick, E., Delvigne, A. S., Orange, F., Peulen, O., Dakwar, G. R., Diricq, J., Dubois, P., Evrard, B., Remaut, K., Braeckmans, K., De Smedt, S. C., Laloy, J., Dogné, J. M., Feller, G., Mespouille, L., Mottet, D. & Piel, G., 25 Jan 2017, In : ACS Applied Materials and Interfaces. 9, 3, p. 2181-2195 15 p.

Research output: Contribution to journalArticle

polycarbonate
Histone Deacetylases
Polycarbonates
Small Interfering RNA
Nanoparticles
Thrombocytopenia
Heparin
Platelet Count
Plasmapheresis
Platelet Aggregation
Disseminated Intravascular Coagulation
Leukemia
Thrombosis
Biomarkers
Thromboplastin

The many facets of community detection in complex networks

Schaub, M. T., Delvenne, J. C., Rosvall, M. & Lambiotte, R., 1 Dec 2017, In : Applied Network Science. 2, 1, 4.

Research output: Contribution to journalArticle

Open Access
File
Community Detection
Complex networks
Facet
Complex Networks
Machinery
Multiple Drug Resistance
Myeloid Cells
MicroRNAs
Acute Myeloid Leukemia
HL-60 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Blood Vessels
Safety
Meta-Analysis
2016
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Meta-Analysis
Odds Ratio
Blood Vessels

Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

Nchimi, A., Courtois, A., El Hachemi, M., Touat, Z., Drion, P., Withofs, N., Warnock, G., Bahri, M. A., Dogne, J-M., Cheramy-Bien, J. P., Schoysman, L., Joskin, J., Michel, J. B., Defraigne, J. O., Plenevaux, A. & Sakalihasan, N., 1 Jul 2016, In : European Radiology. 26, 7, p. 2378-2386 9 p.

Research output: Contribution to journalArticle

Abdominal Aortic Aneurysm
Thrombosis
Growth
Deoxyglucose
Magnetic Resonance Imaging
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Meta-Analysis
Blood Vessels
Randomized Controlled Trials

Suitability of analytical methods to measure solubility for the purpose of nanoregulation

Tantra, R., Bouwmeester, H., Bolea, E., Rey-Castro, C., David, C. A., Dogné, J. M., Jarman, J., Laborda, F., Laloy, J., Robinson, K. N., Undas, A. K. & Van Der Zande, M., 7 Feb 2016, In : Nanotoxicology. 10, 2, p. 173-184 12 p.

Research output: Contribution to journalArticle

Nanostructured materials
Solubility
Nanostructures
Cosmetics
Risk assessment
Factor XIIa
Coumarins
Structure-Activity Relationship
Enzyme Precursors
Blood Coagulation
2015
6 Downloads (Pure)
Endothelial Cells
Inflammation
Phenotype
Neoplasms
Interleukin-8