Laboratory of Cellular Biochemistry and Biology

Projects

Projects per year 1991 2000 2001 2003 2004 2005 2006 2008 2011 2014 2016 2018 2019 2022 2027

• 2 Not started
• 21 Active
• 194 Finished

Projects per year

Search results

• Active

  Plateforme technologique d’excellence interuniversitaire sur les méthodes alternatives à l'expérimentation animale

  Renard, H., Arnould, T., Muylkens, B., Nicaise, C., Vandeweerd, J., SU, B. L. & Poumay, Y.

  1/12/22 → 30/06/23

  Project: Research

• KeraSEN: Pathways of senescence induction in keratinocytes and impact of their secretome on the cellular microenvironment

  Debacq-Chainiaux, F., Poumay, Y. & Bouriez, I.

  1/10/22 → 30/09/26

  Project: PHD

• ENCAPCELRAPY: Differentiation and Encapsulation of β-like cells for the treatment of type 1 Diabetes Mellitus

  Arnould, T. & SU, B. L.

  1/10/22 → 30/09/27

  Project: Research

  • insulin-dependent diabetes mellitus 100%
  • Stem cells 96%
  • Encapsulation 77%
  • Medical problems 75%
  • encapsulation 70%

• BAR domain proteins in unconventional endocytic mechanisms: Roles in cancer and intracellular bacterial infections

  Renard, H. & De Bolle, X.

  1/01/22 → 31/12/23

  Project: Research

  • amphiphysin 100%
  • Protein Domains 62%
  • Bacterial Infections 57%
  • Clathrin 57%
  • Membranes 36%

• Study of the mechanisms leading to HIF-1alpha stabilisation and BNIP3L expression in Brucella abortus-infected cells: role in mitophagy and tropism of the bacteria for the mitochondria

  Arnould, T.

  1/01/22 → 31/12/23

  Project: Research

  • mitophagy 100%
  • tropisms 84%
  • Brucella melitensis biovar Abortus 79%
  • Brucella 75%
  • mitochondria 47%

• Observing life in 4D and high resolution for the characterization of novel dynamic biological mechanisms

  Renard, H., Declèves, A. E., Hermand, D. & Poumay, Y.

  1/01/22 → 31/12/23

  Project: Research

  • Biological Phenomena 100%
  • Nobel Prize 77%
  • Phototoxic Dermatitis 72%
  • Technology 67%
  • Belgium 59%

• PromiGold: Potentiation of protontherapy through mitophagy inhibition and gold nanoparticle induced oxidative stress

  Heuskin, A., Arnould, T. & Lopopolo, G.

  1/01/22 → 31/12/23

  Project: Research

  • Mitophagy 100%
  • Gold 74%
  • Nanoparticles 65%
  • Mitochondria 60%
  • Oxidative Stress 53%

• Radiation-induced immune-modulation in head and neck cancer

  SCHIFFLERS, C. & MICHIELS, C.

  1/01/22 → 30/09/23

  Project: Research

  • Head and Neck Neoplasms 100%
  • Radiation 74%
  • Radiotherapy 68%
  • Squamous Cell Carcinoma of Head and Neck 37%
  • Neoplasms 32%

• Study of the role of mitochondrial Sirtuins 3, 4 and 5 in the differentiation of hiPSCs into hepatocyte-like cells and in the early events of NAFLD/NASH

  ROLIN , C., Arnould, T. & Renard, P.

  1/10/21 → 30/09/23

  Project: Research

  • induced pluripotent stem cells 100%
  • hepatocytes 57%
  • oxidative stress 25%
  • cells 20%
  • fatty acid metabolism 19%

• Impact of ambient air pollution during gestation on placental senescence

  Debacq-Chainiaux, F., Nawrot, T. & Millen, J.

  1/10/21 → 30/09/25

  Project: PHD

• Deciphering of the mitochondrial co-translational import mechanism in mammals, identification of the main actors and characterization of their physiological relevance

  MEURANT, S., Renard, P. & Arnould, T.

  1/10/21 → 30/09/23

  Project: Research

  • imports 100%
  • mitochondria 78%
  • mammals 75%
  • ribosomes 65%
  • RNA-binding proteins 43%

• Reprogramming of macrophages toward M1 phenotype through gold nanoparticle and proton exposure

  Iyer, S., Heuskin, A. & MICHIELS, C.

  11/08/21 → 11/08/25

  Project: PHD

• REPTAM: Reprograming of macrophages toward M1 phenotype through gold nanoparticle and proton exposure

  Heuskin, A., Iyer, S. & MICHIELS, C.

  1/08/21 → 30/07/23

  Project: Research

  • Gold Nanoparticle 100%
  • Proton 78%
  • Dioxygen 58%
  • Phagocytic 54%
  • Mannose 43%

• Impact of the UPR pathway on the establishment of UVB induced senescence of human dermal fibroblasts

  Debacq-Chainiaux, F., Giroud, J. & Pluquet, O.

  1/10/20 → 31/03/24

  Project: PHD

• Upgrading of approved university animal facilities to carry out research with high industrial potential

  MICHIELS, C. & Vandeweerd, J.

  5/12/19 → 4/12/23

  Project: Research

  • animals 100%

• PROTHER-WAL: Proton Therapy Research in Wallonia

  MICHIELS, C., Lucas, S., Heuskin, A., Golli, E., Coos, R., Cini, N., Penninckx, S., Cardinal, M. & Henrotin, S.

  1/01/19 → 31/07/26

  Project: Research

  • Oxidoreductases 100%
  • Gold nanoparticles 96%
  • Gold 57%
  • Gold Nanoparticle 54%
  • Nanoparticles 50%

• CAREGIVER2: Soutien des soins informels aux personnes agées fragiles

  Debacq-Chainiaux, F.

  24/06/14 → …

  Project: Research

  • Frail Elderly 100%
  • Caregivers 66%
  • Patient Care 59%
  • Home Care Services 32%
  • Elderly 20%

• Télévie: Study of the function of the TMEM45A protein that has been identified in the resistance of cancer cells to chemotherapeutic agents

  MICHIELS, C. & CHARLIER, C.

  1/01/13 → …

  Project: PHD

  • Proteins 100%
  • Neoplasms 87%
  • Hypoxia 80%
  • Tumor Microenvironment 35%
  • Antineoplastic Agents 32%

• convention n° 6221(phase 2) relative à un partenariat d'innovation technologique intitulé VALOSTEM (PHASE 2), mis en oeuvre par le pôle de compétitivité BIOWIN

  Arnould, T.

  1/01/12 → …

  Project: Research

• Etude de effets de l’hypoxie intermittente et d’un environnement pro-inflammatoire sur les phénotypes angiogénique et inflammatoire des cellules endothéliales tumorales

  TELLIER, C. & MICHIELS, C.

  1/10/11 → …

  Project: PHD

• plateforme de morphologie analytique

  MICHIELS, C., Raes, M. & Poumay, Y.

  1/01/11 → …

  Project: Research

• Not started

  Modifications structurelles et fonctionnelles des microdomaines membranaires lipidiques au cours de la sénescence du kératinocyte

  Warnon, C., Debacq-Chainiaux, F. & Poumay, Y.

  Project: PHD

• POLBEES: POLBEES

  Renard, P.

  Project: Research

  • research programs 100%
  • research projects 99%
  • bees 80%
  • pesticides 72%
  • pollen 69%
• Finished

  BAR domain proteins in endocytosis: a missing link between membrane curvature, cargo sorting, and signaling?

  Renard, H.

  1/01/21 → 1/12/22

  Project: Research

  • amphiphysin 100%
  • Protein Domains 62%
  • Endocytosis 62%
  • Clathrin 46%
  • Vesicular Transport Adaptor Proteins 38%

• Design and Synthesis of Hybrid Microcapsules for Mammal Cell Encapsulation devoted to Cell Therapy

  NEUMANN, M., SU, B. L. & Arnould, T.

  1/01/21 → 30/09/22

  Project: PHD

  • Microcapsule 100%
  • Encapsulation 78%
  • Immunosuppressive Agent 40%
  • Insulin Derivative 31%
  • Sol Gel Process 24%

• Reprogramming tumour-associated macrophages with proton irradiation to boost the effects of immunotherapy in pancreatic cancer

  Huart, C. & MICHIELS, C.

  1/10/20 → 30/09/22

  Project: Research

  • Protons 100%
  • Pancreatic Neoplasms 92%
  • Immunotherapy 86%
  • Macrophages 68%
  • Neoplasms 31%

• Study of the mechanisms leading to mitochondrial fragmentation in Brucella-infected cells and analysis of its functional consequences

  Verbeke, J., Arnould, T. & De Bolle, X.

  1/10/20 → 30/09/22

  Project: Research

  • Brucella 100%
  • Brucella melitensis biovar Abortus 65%
  • cells 26%
  • mitochondria 23%
  • inflammasomes 17%

• MITOCHONBRU: Study of the Brucella interactions with mitochondria of the host cells and characterization of mitochondrial fragmentation consequences

  Arnould, T.

  1/01/20 → 31/12/21

  Project: Research

  • Brucella 100%
  • mitochondria 62%
  • inflammasomes 28%
  • bacteria 27%
  • cells 26%

• Study of the role of heme synthesis and peroxisomal metabolism in the exit from naive pluripotency

  Detraux, D., Renard, P. & Arnould, T.

  1/01/20 → 30/09/21

  Project: Research

  • Heme 100%
  • Pharmacological Metabolism 83%
  • Nitric Oxide 68%
  • Hemoprotein 45%
  • Metabolic 29%

• Deciphering of the mitochondrial co-translational import mechanism in mammals, identification of the main actors and characterization of their physiological relevance

  MEURANT, S. & Renard, P.

  1/10/19 → 30/09/21

  Project: Research

  • imports 100%
  • mammals 75%
  • ribosomes 65%
  • RNA-binding proteins 43%
  • biogenesis 35%

• Tumor immunosuppression modulation by proton irradiation in order to boost the anti-PD-1 immune checkpoint blocker effects

  MICHIELS, C.

  1/10/19 → 30/09/21

  Project: Research

  • Protons 100%
  • Immunosuppression 88%
  • Immunosuppressive Agents 36%
  • Neoplasms 31%
  • Macrophages 30%

• Study of the role of Sirtuin 3 in diet-induced obesity of transgenic mice that overexpress the mitochondrial deacetylase and characterization of its role in white adipogenic differentiation

  STORDER, J., Arnould, T. & Renard, P.

  1/01/19 → 30/09/20

  Project: Research

  • Sirtuin 3 100%
  • adipogenesis 84%
  • obesity 65%
  • Cell Differentiation 51%
  • Metabolic 51%

• Tumor macrophage rewiring by proton irradiation in order to boost the anti-PD-L1 immune checkpoint blocker effects

  LONGTON, E. & MICHIELS, C.

  1/01/19 → 30/09/20

  Project: Research

  • Protons 100%
  • Macrophages 68%
  • Neoplasms 31%
  • Tumor Microenvironment 22%
  • Phenotype 19%

• Study of the translational regulation of mitochondrial remodeling in a model of human Bone Marrow Mesenchymal Stem Cell hepatogenic differentiation

  CARUSO, M., Renard, P. & Najimi, M.

  1/01/19 → 30/09/20

  Project: Research

  • Mesenchymal Stem Cells 100%
  • Cell Differentiation 90%
  • Stem Cells 82%
  • Eukaryotic Initiation Factor-4E 41%
  • Polyribosomes 35%

• Study of the translation regulation occurring during stem cell hepatogenic differentiation, and potentially involved in mitochondrial biogenesis

  Renard, P.

  1/01/19 → 31/12/20

  Project: Research

  • Organelle Biogenesis 100%
  • Cell Differentiation 64%
  • Stem Cells 57%
  • Mitochondria 43%
  • Peptide Initiation Factors 33%

• Hybrid gold nanoparticles coated with organic polymers and antibodies as a platform for cancer theranostics: cytotoxicity assessment and radiolabeling

  DAEMS, N., MICHIELS, C. & Lucas, S.

  1/01/19 → 30/09/20

  Project: Research

  • Gold Nanoparticle 100%
  • Nanoconjugate 70%
  • Dose 55%
  • Cell Death 25%
  • Cell Viability 23%

• BEST(Bdelloid Extreme Stress Tolerance): Bdelloid rotifers as a model organism to understand extreme stress tolerance

  Arora, R., Van Doninck, K. & Debacq-Chainiaux, F.

  1/10/18 → 31/12/20

  Project: Research

  • Rotifera 100%
  • stress tolerance 82%
  • antioxidants 58%
  • Adineta vaga 58%
  • organisms 51%

• Study of the mechanisms leading to mitochondrial fragmentation in Brucella-infected cells and analysis of its functional consequences

  Verbeke, J., Arnould, T. & De Bolle, X.

  1/10/18 → 30/09/19

  Project: Research

  • Brucella 100%
  • cells 22%
  • Brucella melitensis biovar Abortus 22%
  • vacuoles 15%
  • phenotype 11%

• Synthesis of an alginate-SiO2-TiO2 hybrid material for animal cell encapsulation for cell therapy

  NEUMANN, M., SU, B. L. & Arnould, T.

  1/10/18 → 31/12/20

  Project: PHD

  • alginates 100%
  • encapsulation 97%
  • therapeutics 73%
  • synthesis 51%
  • animals 39%

• How cycling hypoxia initiates endothelial cell-macrophage cooperation to support tumor growth and metastasis

  Delprat, V. & MICHIELS, C.

  1/10/18 → 30/09/20

  Project: Research

  • Hypoxia 100%
  • Macrophages 95%
  • Endothelial Cells 93%
  • Neoplasm Metastasis 61%
  • Neoplasms 52%

• Reprogramming tumour-associated macrophages with proton irradiation to boost the effects of immunotherapy in pancreatic cancer

  Huart, C. & MICHIELS, C.

  1/10/18 → 30/09/19

  Project: Research

  • Protons 100%
  • Macrophages 94%
  • Pancreatic Neoplasms 92%
  • Immunotherapy 90%
  • Neoplasms 45%

• Study of the role of Sirtuin 3 in transgenic mice that overexpress the mitochondrial deacetylase exposed to a high fat diet and characterization of its role in white adipogenic differentiation

  Arnould, T.

  1/01/18 → 31/12/19

  Project: Research

  • adipogenesis 100%
  • obesity 77%
  • high fat diet 53%
  • mice 42%
  • homeostasis 42%

• Acquisition of a new mass spectrometer for proteomics analyses at UNamur

  Renard, P. & Muylkens, B.

  1/01/18 → 31/12/19

  Project: Research

  • Proteomics 100%
  • Mass Spectrometry 73%
  • Proteins 50%
  • Research Personnel 37%
  • Equipment and Supplies 32%

• Proton irradiation-induced tumor macrophage rewiring in order to boost immunotherapy

  MICHIELS, C.

  1/01/18 → 31/12/19

  Project: Research

  • Protons 100%
  • Macrophages 95%
  • Immunotherapy 93%
  • Neoplasms 53%
  • Immunosuppressive Agents 41%

• Regulation of the mitochondrial proteome during naïve-to-primed human embryonic stem cell transition

  Detraux, D., Renard, P. & Arnould, T.

  1/10/17 → 31/12/19

  Project: Research

  • embryonic stem cells 100%
  • mitochondria 68%
  • proteome 65%
  • gene editing 28%
  • acetylation 24%

• Télévie: Determination of the genes implicated in intrinsic resistance to proton beam therapy for the treatment of pancreatic adenocarcinoma

  MICHIELS, C. & Le Calve, B.

  1/10/17 → 30/09/19

  Project: Research

  • Proton Therapy 100%
  • Adenocarcinoma 64%
  • Genes 26%
  • Radiotherapy 25%
  • Surgical Pathology 22%

• Contextual synthetic lethality to optimise glioblastoma cell responses to proton and X-ray irradiation: an upscaling approach to study radiosensitisation and radioresistance

  Wera, A., MICHIELS, C. & Lucas, S.

  1/10/17 → 30/09/20

  Project: Research

  • Synthetic Lethal Mutations 100%
  • Protons 69%
  • Glioblastoma 67%
  • X-Rays 52%
  • DNA Repair-Deficiency Disorders 21%

• Bourse post-doc 12 mois

  AL-QARAGHULI, S. & Debacq-Chainiaux, F.

  1/07/17 → 30/06/18

  Project: Research

• CURSTEM: Cellules souches mésenchymateuses d’origine musculaire dopées par un complexe hydrosoluble curcumine-cyclodextrine (NDS27)

  Renard, P.

  1/05/17 → 30/04/21

  Project: Research

  • cyclodextrins 100%
  • mesenchymal stromal cells 99%
  • curcumin 97%
  • muscles 49%
  • water 31%

• Télévie: Inflammation and hypoxia: a reciprocal influence that leads to cancer resistance to treatments

  MICHIELS, C. & CLEMENT, F.

  1/01/17 → 30/09/18

  Project: Research

  • Hypoxia 100%
  • Inflammation 74%
  • Neoplasms 40%
  • Macrophages 35%
  • Therapeutics 20%