Faculty of Medicine

Projects

Projects per year 1963 2001 2003 2004 2005 2006 2007 2011 2012 2013 2014 2019 2020 2022 2028

• 7 Not started
• 71 Active
• 160 Finished

Projects per year

Search results

• Active

  From the identification of pathogenic autoantibodies in patients with neurological post-acute sequelae of COVID-19 to mechanisms of neuronal-derived neoantigen production

  MIGNOLET, M., Nicaise, C. & Gillet, N.

  16/01/23 → …

  Project: PHD

  • SARS Virus 100%
  • Central Nervous System 75%
  • Antigens 64%
  • Autoantibodies 62%
  • APOBEC Deaminases 58%

• Development of 3D-brain organoids in the context of SARS-CoV-2 infection

  MIGNOLET, M. & Nicaise, C.

  16/01/23 → …

  Project: Research

• reDox: Regulation of the synthesis of the epitranscriptomic modification dihydrouridine (D) during an oxidative stress

  Hermand, D.

  1/01/23 → 31/12/24

  Project: Research

  • Dihydrouridine 100%
  • Oxidative Stress 59%
  • Modification 33%
  • Redox State 17%
  • Uridine 16%

• Plateforme technologique d’excellence interuniversitaire sur les méthodes alternatives à l'expérimentation animale

  Renard, H., Arnould, T., Muylkens, B., Nicaise, C., Vandeweerd, J., SU, B. L. & Poumay, Y.

  1/12/22 → 30/06/23

  Project: Research

• Structure-based drug design and synthesis of selective smallmolecular- weight inhibitors of FXIIa, an attractive target from the intrinsic coagulation cascade

  TRAINA, A., Lanners, S. & POCHET, L.

  1/10/22 → 31/12/24

  Project: Research

  • Coagulation 100%
  • Serine 91%
  • Thrombotic 75%
  • Anticoagulant Agent 62%
  • Oxyanion 59%

• Targeted covalent probes to interfere with homomeric proteinprotein interactions: inhibition of Mycobacterium tuberculosis serine phosphatase through covalent modification of key amino acids

  Garcia Llinas, X., POCHET, L. & Wouters, J.

  1/10/22 → 30/09/24

  Project: Research

  • Oligomerization 100%
  • Serine 91%
  • Ser-Tyr 42%
  • Lys-Ser 41%
  • Fluoride 39%

• KeraSEN: Pathways of senescence induction in keratinocytes and impact of their secretome on the cellular microenvironment

  Debacq-Chainiaux, F., Poumay, Y. & Bouriez, I.

  1/10/22 → 30/09/26

  Project: PHD

• PGCspecification: Specification of precursor germ cells (PGC) from somatic cells during early embryogenesis in C. elegans

  PONSARD, P. & Hermand, D.

  1/10/22 → 30/09/24

  Project: Research

  • Terminal Repeat Sequences 100%
  • Germ Cells 81%
  • Embryonic Development 76%
  • Positive Transcriptional Elongation Factor B 45%
  • Phosphotransferases 42%

• Deciphering the CTD code of RNA polymerase II in healthy and cancer cells

  Hermand, D., Bachand, F. & Jacques, P. É.

  1/09/22 → 31/08/25

  Project: Research

  • Cyclin-Dependent Kinases 100%
  • RNA Polymerase II 99%
  • Phosphorylation 58%
  • Neoplasms 27%
  • Catalytic RNA 18%

• MULTICOATINGS4DENTALIMPLANTS: Design and development of advanced multifunctional nano-coatings to enhance the clinical performances of dental implants

  Houssiau, L., Mantovani, D., Houde, V. & Laloy, J.

  1/09/22 → 31/08/25

  Project: Research

  • dental prosthesis 100%
  • prostheses 75%
  • coatings 52%
  • titanium 27%
  • bones 21%

• Clinical Pharmacology Research Group

  Douxfils, J., Dogne, J., Musuamba Tshinanu, F., MASEREEL, B., Wieers, G., Haguet, H., RONVAUX, L., Donis, N., Morimont, L., Evrard, J., Siriez, R., Gillot, C., FAVRESSE, J., BOUVY, C., Djokoto, H., Didembourg, M., David, C., Melchionda, S., Maloteau, V., Boucher, A., Devel, P., Modaffari, E., Vandeputte, M., De Messemaeker, A., Decarpentrie, J., Vassart, J. & De Groote, A.

  1/04/22 → …

  Project: Research Axis

  • SARS Virus 100%
  • Estetrol 99%
  • Anticoagulants 60%
  • drospirenone 55%
  • Activated Protein C Resistance 50%

• Développement de motoneurones phréniques à partir de cellules souches pluripotentes induites

  Halloin, N. & Nicaise, C.

  1/02/22 → …

  Project: Research

• Dihydrouridine: Epitranscriptomic of dihydrouridine in pro- and eukarya

  Hermand, D. & Hallez, R.

  1/01/22 → 31/12/23

  Project: Research

  • tubulin 100%
  • transcriptome 87%
  • chaperonins 66%
  • uridine 54%
  • cytoskeleton 52%

• Deciphering entry mechanisms and axoplasmic transport of SARS-CoV-2 from peripheral nerve endings

  Nicaise, C.

  1/01/22 → 31/12/23

  Project: Research

  • SARS Virus 100%
  • Axonal Transport 84%
  • Nerve Endings 82%
  • Peripheral Nerves 66%
  • Neurites 56%

• Transcriptional control of a developmenal transition in Caenorhabditis elegans

  Stubbe, F. & Hermand, D.

  1/01/22 → 30/09/23

  Project: Research

  • RNA Polymerase II 100%
  • Caenorhabditis elegans 94%
  • Gene Expression Regulation 46%
  • Cues 37%
  • Cell Differentiation 34%

• Fragment-based drug discovery approach to search new lead compounds targeting FXIIa, a serine protease implicated in the coagulation pathway, the kinin-kallikrein system, and the immune response

  POCHET, L.

  1/01/22 → 31/12/23

  Project: Research

  • Factor XIIa 100%
  • Kallikrein-Kinin System 90%
  • Serine Proteases 70%
  • Drug Discovery 64%
  • Lead 56%

• Observing life in 4D and high resolution for the characterization of novel dynamic biological mechanisms

  Renard, H., Declèves, A. E., Hermand, D. & Poumay, Y.

  1/01/22 → 31/12/23

  Project: Research

  • Biological Phenomena 100%
  • Nobel Prize 77%
  • Phototoxic Dermatitis 72%
  • Technology 67%
  • Belgium 59%

• Drosha homolog Pac1 functions in microRNA-like biogenesis and cellular differentiation control in fission yeast S. pombe

  Yague-Sanz, C. & Hermand, D.

  1/10/21 → 30/09/24

  Project: Research

  • Schizosaccharomyces 100%
  • MicroRNAs 69%
  • RNA 38%
  • Eukaryota 28%
  • Saccharomycetales 16%

• Identification of chemical inhibitors of Elongator to counteract resistance to conventional therapies in BRAFV600E melanoma

  TRICQUET, P. & Hermand, D.

  1/10/21 → 30/09/23

  Project: Research

  • Melanoma 100%
  • Transfer RNA 65%
  • Uridine 24%
  • Saccharomycetales 24%
  • Glycolysis 21%

• The GLIOMARKERS project - development of biomarkers for the diagnostic and the prognostic of glioblastoma

  Douxfils, J., RONVAUX, L., Donis, N., Maloteau, V. & Decarpentrie, J.

  1/10/21 → …

  Project: Research

  • Liquid Biopsy 100%
  • Glioblastoma 70%
  • Circulating Tumor DNA 20%
  • Circulating MicroRNA 19%
  • Circulating Neoplastic Cells 17%

• Accompagnement de l'aide à la réussite

  BAILLIEUL, D., Boraita, F., Calicis, C., Defreyne, E., De Vleeschouwer-Dieudonne, M., Goffin, C., Fischer, L., Minet, M., PONDEVILLE, S. & Wathelet, V.

  3/05/21 → …

  Project: Research

• SoGerSpe: Soma-Germline specification during embryogenesis in C. elegans

  Hermand, D.

  1/01/21 → 1/12/24

  Project: Research

  • Caenorhabditis elegans 100%
  • Carisoprodol 99%
  • Germ Cells 89%
  • Embryonic Development 83%
  • RNA Polymerase II 26%

• Optimisation of antibacterial and antiviral coatings by physical ways

  Job, V. & Lucas, S.

  15/09/20 → 31/08/26

  Project: PHD

• Evaluation de la protéine SV2A comme marqueur non-invasif de lésion médullaire

  Halloin, N. & Nicaise, C.

  1/09/20 → …

  Project: Research

  • Synaptic Vesicles 100%
  • Spinal Cord Injuries 82%
  • Positron-Emission Tomography 80%
  • Glycoproteins 73%
  • Theoretical Models 69%

• Effets des traumatismes médullaires légers et répétés sur l'apparition ou exacerbation des lésions tauopathiques

  Halloin, N. & Nicaise, C.

  1/09/20 → …

  Project: PHD

• Improve the diagnosis and treatment of esophageal cancer by identifying circulating tumour DNA and characterizing genome alterations leading to treatment failure.

  Gillet, J., Laes, J. F. & LEFEVRE, S.

  1/04/20 → 31/03/24

  Project: Research

• The COVILAB project : Clinical laboratory investigations related to COVID-19

  Douxfils, J., Dogne, J., FAVRESSE, J., Tre-Hardy, M., MULLIER, F., Haguet, H., Hardy, M., Melchionda, S., BOUVY, C., Morimont, L., Gillot, C., Djokoto, H., Alpan, L., Devel, P., Modaffari, E. & Maloteau, V.

  13/03/20 → …

  Project: Research

  • SARS Virus 100%
  • Antibodies 27%
  • Coronavirus 24%
  • Vaccines 23%
  • Neutralizing Antibodies 20%

• MycEpi: Développement et validation d’un modèle multivalent de dermatophytose in vitro, en vue de son exploitation analytique, diagnostique et pharmacologique

  Poumay, Y. & Faway, E.

  1/01/20 → 31/12/23

  Project: Research

  • Tinea 100%
  • Arthrodermataceae 75%
  • dermatomycoses 53%
  • keratinophilic fungi 47%
  • Spores 44%

• Nano4Life: Innovative multidrug nanomedicines for myocardial ischemia reperfusion injuries treatment

  Dogne, J. & Couvreur, P.

  1/01/20 → 31/12/23

  Project: Research

  • Nanomedicine 100%
  • Myocardial Reperfusion Injury 86%
  • Nanoparticles 79%
  • Reperfusion Injury 76%
  • Adenosine 66%

• Surface analysis of reconstructed human epidermis, with a focus on Atopic Dermatitis inflammatory condition

  Houssiau, L., Delvaux, X. & Poumay, Y.

  1/09/19 → …

  Project: PHD

• The HIC Project : Evaluation of hormone-induced coagulopathy

  Dogne, J., Douxfils, J., Morimont, L., Didembourg, M. & Evrard, J.

  1/09/19 → …

  Project: Research

  • Estetrol 100%
  • Activated Protein C Resistance 81%
  • Contraceptives, Oral, Combined 60%
  • drospirenone 60%
  • Thrombin 52%

• The CAF project - a new tool for the assessment of the clot formation

  Douxfils, J., Dogne, J., Evrard, J., Morimont, L. & Maloteau, V.

  1/09/18 → …

  Project: Research

  • edoxaban 100%
  • Activated Protein C Resistance 95%
  • Protein C 90%
  • Prothrombin Time 73%
  • Oral Combined Contraceptive 52%

• Study of the 3D arrangement of Phrenic Motor Neurons (PhMN) pool and their long-range neural connectivity in the healthy and injured mouse cervical spinal cord

  Nicaise, C. & Fratini, M.

  1/01/17 → …

  Project: Research

• The DIT project : Drug induced thrombosis - a special focus on kinase and PARP inhibitors and

  Douxfils, J., MULLIER, F., Haguet, H. & RONVAUX, L.

  1/09/15 → …

  Project: Research

  • Protein-Tyrosine Kinases 100%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 75%
  • ponatinib 67%
  • 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 64%
  • Dasatinib 58%

• keratinocyte senescence

  Poumay, Y.

  6/12/13 → …

  Project: Research

• Implication d’un gène candidat dans la chimiorésistance de lignées issues de carcinomes spinocellulaires en conditions hypoxiques

  Graux, C. & Poumay, Y.

  1/12/13 → …

  Project: Research

• Test sanguin de détection/pronostic de cancer

  POPA, C., De Ronde, T., Rahier, J., D'Hondt, L., Graux, C., George, F., Finet, L. & Herzog, M.

  1/12/13 → …

  Project: Research

• Implication of microparticles in thrombosis associated with paroxysmal nocturnal hemoglobinuria

  Chatelain, B., Chatelain, C. & Dogne, J.

  1/12/13 → …

  Project: Research

• Réalisation d'un atlas neuro-anatomique, histologique et fonctionnel de la moelle épinière humaine

  Nicaise, C. & Jankovski, A.

  1/10/13 → …

  Project: Research

• Caractérisation de modèles animaux de syndrome de démyélinisation osmotique

  Bouchat, J. & Nicaise, C.

  1/10/13 → …

  Project: PHD

• Télévie: Study of the function of the TMEM45A protein that has been identified in the resistance of cancer cells to chemotherapeutic agents

  MICHIELS, C. & CHARLIER, C.

  1/01/13 → …

  Project: PHD

  • Proteins 100%
  • Neoplasms 87%
  • Hypoxia 80%
  • Tumor Microenvironment 35%
  • Antineoplastic Agents 32%

• Differentiation modulation of cancer and normal keratinocyte by inflammation

  Hermant, M. & Poumay, Y.

  14/03/12 → …

  Project: PHD

• The BIOCOAG project : Biological assessment of the control of anticoagulation

  Douxfils, J., MULLIER, F., Dogne, J., Siriez, R. & Evrard, J.

  1/09/11 → …

  Project: Research

  • Anticoagulants 100%
  • Thrombin 61%
  • Factor Xa Inhibitors 47%
  • Anticoagulant Agent 41%
  • Rivaroxaban 37%

• Badiane : mobile cell to support disabled children's inclusion in creche

  MERCIER, M., QUINAUX, A., Vanrusselt, M., BOTTON, M., Couclet, C., PACHIKIAN, S. & DEFIZE, H.

  1/01/10 → …

  Project: Research

• HAXY, physical disability, quality of life and sexuality

  MERCIER, M., Berrewaerts, J., MOREAU, M., DEFIZE, H., WOUE, D. & Vincent, C.

  1/10/09 → …

  Project: Research

  • Information Sharing 100%
  • Sexuality 99%
  • Health Professionals 80%
  • Web Sites 65%
  • Quality of Life 63%

• PK study in normal and nephrectomized rabbits

  Caron, N.

  15/03/08 → …

  Project: Research

• Characterization of the lysosomal membrane protein p40 : study of the phenotype of mutant mice

  Boonen, M., Jadot, M. & Lambert De Rouvroit, C.

  1/01/08 → …

  Project: Research

• Batterie d'Attention William Lennox

  Peters, J.

  1/07/07 → …

  Project: Research

  • gerontology 100%
  • psychology 84%
  • testing 26%

• Socio-economic approachs of the handicap

  GRAWEZ, M. & MERCIER, M.

  1/01/07 → …

  Project: Research

• Behavioral Neuroscience Research on the Mouse Model of Human Diseases

  Desseilles, M., Berrewaerts, J., Peters, J. & Houbeau, G.

  1/01/07 → …

  Project: Research

  • neurophysiology 100%
  • human diseases 86%
  • mice 61%
  • animal models 46%
  • gene targeting 28%